Many congratulations to Lizzy Fisher, a former PhD student and later Programme Leader at MRC Harwell, who was recently elected a Fellow of the Royal Society

Elizabeth Fisher elected a Fellow of the Royal Society | Mary Lyon Centre

"The people I’ve worked with at Harwell have had a huge part in shaping my career, so this is for you too.”

har.mrc.ac.uk

Excited to share our newly published editorial article in @dmmjournal.bsky.social As discussions on animal research and alternative methods evolve we wanted to contribute a balanced, evidence-led perspective on the future of preclinical research. journals.biologists.com/dmm/article/...

Excited to share results from the first Business Engagement Fund from the MRC, supporting #academia-#industry collaboration. Work from Nick Greene and Outfox Bio shows LNP-mRNA delivery works effectively in an NKH mouse model—proof of concept for therapeutic mRNA. nmgn.mrc.ukri.org/news/a-busin...

A Business Engagement Fund project to test Lipid Nanoparticle (LNP)-mediated mRNA delivery and efficacy | National Mouse Genetics Network

The Medical Research Council provided £750K in funding for the National Mouse Genetics Network’s Business Engagement Fund with a call for applications in early 2023. The Business Engagement Fund suppo...

nmgn.mrc.ukri.org

If you're not a subscriber, you will have just missed our Spring 2026 Newsletter, but don't worry - you can find it here and click subscribe to make sure you don't miss out next time! mailchi.mp/637ad22cdcdb...

Back in November, our Horizon Scanning Working Group held its second workshop designed to build a UK community around the latest advances in genome engineering technologies: nmgn.mrc.ukri.org/news/horizon...

Horizon Scanning Working Group genome engineering workshop | National Mouse Genetics Network

On the 26th and 27th of November, the Network’s Horizon Scanning Working Group held its second workshop designed to build a UK community around the latest advances in genome engineering technologies. ...

nmgn.mrc.ukri.org

Stealth BioTherapeutics has today announced an award from our Business Engagement Fund to support a new collaboration to evaluate the effects of their compound SBT-589 on biomarkers of disease in a mouse model of Leigh syndrome, a rare mitochondrial disorder: nmgn.mrc.ukri.org/news/busines...

Business Engagement Fund award to support mitochondrial disease research | National Mouse Genetics Network

Stealth BioTherapeutics, a commercial-stage biotechnology company focused on the discovery, development, and commercialisation of novel therapies for diseases involving mitochondrial dysfunction, have...

nmgn.mrc.ukri.org

Clinicians and researchers with an interest in #mitochondrial disease: Queen Square Advances in Mitochondrial Medicine (5 May 2026) is a CPD-approved course covering pre-clinical & translational research, and the latest updates in NHS diagnostic testing. Registration: www.ucl.ac.uk/brain-scienc...

Queen Square Advances in Mitochondrial Medicine 2026

The London Mitochondrial Centre is hosting a one-day symposium.

ucl.ac.uk

Earlier this month we held a hugely successful hackathon focused on the spatial analysis software MuSpAn to conduct a deep dive study on the progression of liver metastases from colorectal cancer. Read more: nmgn.mrc.ukri.org/news/muspan-...

MuSpAn hackathon – Team Science in Action! | National Mouse Genetics Network

The MRC National Mouse Genetics Network (NMGN) celebrated a hugely successful hackathon two weeks ago (2nd-6th March), focused on the spatial analysis software MuSpAn, a tool for the analysis of […]

nmgn.mrc.ukri.org

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of #MeetTheExpert posts features Owen Sansom, whose group has created advanced mouse models matching a variety of human colorectal cancer subtypes. nmgn.mrc.ukri.org/working-grou...

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of #MeetTheExpert posts features Laura Greaves, whose group investigates the role of age-related mitochondrial DNA mutations in cancer biology nmgn.mrc.ukri.org/working-grou...

MAPK-driven epithelial cell plasticity underlies colorectal cancer therapeutic resistance: Members of our Cancer Cluster contributed to a recent paper that provides insight into resistance to therapy and suggests strategies that may improve therapeutic efficacy nmgn.mrc.ukri.org/news/mapk-dr...

MAPK-driven epithelial cell plasticity underlies CRC therapeutic resistance | National Mouse Genetics Network

(White et al., Cancer Research UK Scotland Institute and collaborators across the MRC National Mouse Genetics Network – Cancer Cluster) Colorectal cancer (CRC) is a genetically complex disease, yet re...

nmgn.mrc.ukri.org

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Prof Robin Williams, whose group uses Dictyostelium to identify the proteins targeted by drugs nmgn.mrc.ukri.org/working-grou...

Fresh insights reveal how cancer gene mutations drive tumour growth: Andrew Wood (lead of our Degron Cluster) has co-led a team that created a comprehensive map that shows how hundreds of possible mutations in a key cancer gene influence tumour growth nmgn.mrc.ukri.org/news/fresh-i...

Fresh insights reveal how cancer gene mutations drive tumour growth | National Mouse Genetics Network

Scientists have created a comprehensive map showing how hundreds of possible mutations in a key cancer gene influence tumour growth, offering a new insight that could guide the development of […]

nmgn.mrc.ukri.org

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series highlighting our diverse expertise features Dr Andrew Wood, whose lab uses genome editing and targeted protein degradation to study genetic disease using cell lines, organoids, and mice.

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Alex Whitworth, whose group uses Drosophila models of neurodegenerative diseases. nmgn.mrc.ukri.org/working-grou...

The MRC National Mouse Genetics Network’s Best Models Working Group connects researchers with the right expertise in biological models and computational tools as part of our commitment to the #3Rs. nmgn.mrc.ukri.org/working-grou... #MeetTheExpert

A study led by Owen Sansom, Director of the National Mouse Genetics Network, has identified the protein NPM1 as a potential therapeutic target in liver and bowel cancers: www.bbc.co.uk/news/article...

Scientists discover potential new treatment to tackle cancer

The research focused on the genetic faults that allow the disease to hijack a signalling system in the body.

bbc.co.uk

The National Mouse Genetics Network has contributed to a new briefing from the UK Parliamentary Office of Science and Technology (POST) that examines the development and use of emerging technologies as alternatives to animals in life sciences research. nmgn.mrc.ukri.org/news/mary-ly...

Mary Lyon Centre and National Mouse Genetics Network contribute to Parliamentary report on research models | National Mouse Genetics Network

The UK Parliamentary Office of Science and Technology (POST) has published a new briefing examining the development and use of emerging technologies as alternatives to animals in life sciences researc...

nmgn.mrc.ukri.org

10 days left to apply for this position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social 🧠🧬🐭

Prof Anthony Isles@profantisles.bsky.social · 8mo ago

📢 Job Alert 📢 Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭 Please repost! www.jobs.ac.uk/job/DPW471/s...

Still time to apply to join this incredible team and contribute to our understanding of neurodevelopmental disorders. #PreclinicalResearch #Genetics

Prof Anthony Isles@profantisles.bsky.social · 7mo ago

10 days left to apply for this position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social 🧠🧬🐭

📢 Job Alert 📢 Post-doc position at #LancasterUniversity working on the #MURIDAE project @mrcmousenetwork.bsky.social Working with #genetic #preclinical models for #schizophrenia 🧠🧬🐭 Please repost! www.jobs.ac.uk/job/DPW471/s...

Senior Research Associate at Lancaster University

An opportunity for an academic position as a Senior Research Associate is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

jobs.ac.uk

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Alex Benedetto, a Senior Lecturer in Integrative Physiology, who works with C. elegans. nmgn.mrc.ukri.org/working-grou...

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Prof Karen Liu, who works on congenital anomalies arising during embryonic development. nmgn.mrc.ukri.org/working-grou...

Great talk by Claire and Rosie this afternoon @mrcmousenetwork.bsky.social meeting! 🧠🧠🧠🧠

Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you! @mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social

Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies

Our Best Models Working Group can offer advice on the use of a range of model systems. The next in our series of posts highlighting our diverse expertise features Dr Xiao Fu, who uses integrative data science and computational modelling approaches to study cancer.

Meet the Experts | National Mouse Genetics Network

We connect researchers with specialists in diverse model systems to support innovation and refinement.

nmgn.mrc.ukri.org

We welcome the government’s effort to provide a clear roadmap for the phasing out of the use of animals in research, while maintaining scientific rigour and safety standards.

NC3Rs@nc3rs.bsky.social · 9mo ago

Today the UK government has released a strategy to support the development, validation and uptake of alternative methods. Read more: www.gov.uk/government/n...

Our Best Models Working Group can offer advice on the use of a range of model systems. Next in our series highlighting the diverse expertise of our Working Group are Prof Matthew Guille and Dr Annie Godwin who work with Xenopus to recreate novel human gene variants thought to cause disease.

Our Best Models Working Group can offer advice on the use of a range of model systems. Over the coming weeks, we will be highlighting the diverse expertise of our Working Group, starting with Julia Cordero, an expert in the use of Drosophila to study intestinal biology. #MeetTheExpert