We propose a semi-distributive model for priming in the lagging strand that sets the RSR in a DNA replication control mode (DRC). The DRC modulates the progression of DNA replication through S phase to ensure the maintenance of genomic stability. @rodrimartinr.bsky.social @cbm-csic-uam.bsky.social

Fresh from the oven! Our new perspectives article where we discuss the interplay between lagging strand DNA replication and the replication stress response. An updated view on lagging strand DNA replication: implications for the replication stress response www.tandfonline.com/doi/full/10....

An updated view on lagging strand DNA replication: implications for the replication stress response

The process of DNA replication is inherently asymmetric. While the leading strand is synthesized continuously, the lagging strand is copied in small fragments, the Okazaki fragments, requiring the ...

tandfonline.com

Fresh from the oven! Ever wondered how cells keep ATR activation controlled during normal DNA replication? Our last paper in @natcomms.nature.com shows that they do it by extracting POLA/PRIM from chromatin using VCP/p97! Still curious? Take a look...🧵🧵🧬🧬

a man is riding a segway in an office with the words welcome aboard below him

ALT: a man is riding a segway in an office with the words welcome aboard below him

media.tenor.com

Very proud of the work of @rodrimartinr.bsky.social, Sara Rodríguez Acebes and the rest of the team. This has been a long effort with many people involved over the years. We have now a better understanding on how VCP/p97 connects priming during DNA replication and the replication stress response.

@cniostopcancer.bsky.social · last yr.

The study, led by @emlecona.bsky.social  (CBM), is published in @natcomms.nature.com, with Sara Rodríguez Acebes (CNIO) and @rodrimartinr.bsky.social (CBM) as first authors, and in collaboration with Juan Mendez' group (CNIO).