www.rawstory.com/russell-voug...
Oval Office erupts as budget hawk tempts Trump to turn on key ally: report
White House officials clashed in the Oval Office over whether President Donald Trump should take a larger knife to the country's largest medical research agency.According to reporting by The Washingto...
rawstory.com
rdcu.be/e3me8 Virus and autoimmunity-another nail in the coffin...
Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis
Nature Immunology - Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive...
rdcu.be
New work on the mechanism by which certain deleterious (senescent-like) stromal cells evade immune clearance. www.biorxiv.org/content/10.6...
Osteoprotegerin-Enabled Immune Evasion of Pathological Adipose Stromal Cells Drives Metabolic Dysfunction in Obesity
Diet-induced obesity (DIO) promotes the accumulation of stromal cells with senescent characteristics in the adipose tissue (AT). Selectively clearing these cells—either through chemical senolytics or ...
biorxiv.org
You don’t need AI. Why? Because you have the greatest natural learning system on the planet that evolved over billions of years, which is the immune system. www.statnews.com/2026/01/15/r...
Regeneron’s chief scientist on Trump’s drug pricing policy, gene therapy, and the problem with AI
Regeneron's chief scientist, George Yancopoulos, has some thoughts about the use of AI in medicine.
statnews.com
endpoints.news/as-gene-edit...
Gene editing's search for a 'holy grail' has led to an explosion of tools, but few cures
Former Intellia scientist John Finn reflects on gene editing's evolution and the closure of Tome Biosciences, highlighting the industry's focus on tools over medicines.
endpoints.news
Arena BioWorks, an ambitious biomedical institute backed by billionaires, abruptly shuts down www.statnews.com/2025/11/04/a... via @statnews.com
Arena BioWorks, an ambitious biomedical institute backed by billionaires, abruptly shuts down
Exclusive: Arena Bioworks, the buzzy research institute that launched with $500 million to support a decade of scientific R&D, is abruptly shutting down, STAT has learned.
statnews.com
In @elife.bsky.social: Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment doi.org/10.7554/eLif...
Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment
doi.org
The “valley of death” is getting increasingly treacherous with NIH in shambles and VCs increasingly training their money at clinical stage companies.
Another one bites the dust. www.fiercebiotech.com/biotech/novo...
Novo shutters cell therapy unit, ending work on potential Type 1 diabetes 'cure'
Novo Nordisk is ending all work in cell therapy, including a Type 1 diabetes program, amid CEO Maziar Mike Doustdar's reorganization. | Novo Nordisk is ending all work in cell therapy, including a Typ...
fiercebiotech.com
It’s another blow to a cell therapy industry that has fallen out of favor as companies struggled to develop next-generation cell therapies that were both effective and could make the complex and expensive treatments more widely accessible. endpoints.news/takeda-stops...
Takeda stops all work in cell therapy
Takeda's decision is another blow to a cell therapy industry that has fallen out of favor.
endpoints.news
Doesnt bode well for muscle preservation combo approach. www.reuters.com/business/hea...
Eli Lilly halts trial testing experimental muscle-preserving drug with Zepbound
Eli Lilly has halted a study of an experimental drug, designed to prevent obesity patients from losing too much muscle, due to strategic business reasons, according to a U.S. registry of clinical trials.
reuters.com
iPSCs are generated by reprogramming adult cells into a pluripotent state, similar to embryonic stem cells, but with the advantage of being derived from the patient's own cells, reducing the risk of immune rejection. What is the evidence this is true?
www.sfchronicle.com/opinion/open...
The U.S. is losing its biotech edge over China — and that’s bad news for the Bay Area
OPINION: From gene therapies to cancer breakthroughs, California has been the driving force behind America’s biotechnology industry. But today, that edge is slipping.
sfchronicle.com
Congrats to Anil Bhushan @bhushanlab.bsky.social and Gregory Ku for receiving a 2025 Beatson Foundation Award for their projects "Targeting Pancreatic Stromal Cells to Halt T1D," and "Using Massively Parallel Monitoring of Insulin Secretion to Make a Better Stem cell-Derived β Cell," respectively.
It is increasingly recognized that immunosuppressive barriers within the tumor microenvironment present a major obstacle to the efficacy of checkpoint inhibitors and adoptive T cell therapies in patients with solid tumors.
Biomea joins the GLP1 bandwagon-what happened to the Menin inhibitor-a pivot or just changing subject? investors.biomeafusion.com/news-release...
investors.biomeafusion.com
Cells in a bag don’t work. The focus is now on immune suppression ftp.fiercehealthpayersummit.com/biotech/vert...
Vertex lays off 125 staffers, slims Rhode Island campus after ditching failed diabetes cell-device combo
Vertex is trimming its Rhode Island footprint on the back of a scrapped “cells plus device” program in diabetes, leaving 125 staffers out of a job. | The company is merging its three buildings at its ...
ftp.fiercehealthpayersummit.com
California state film tax credit doubled while money for scientific research SB 829, an investment that creates new jobs is rejected by senate appropriations. Where is the California that invents the future.
Taurine, a darling of longevity seekers, is found to be unreliable biomarker for aging www.statnews.com/2025/06/05/t... via @statnews.com
Taurine, a darling of longevity seekers, is found to be unreliable biomarker for aging
A study shows levels of the amino acid taurine rise rather than fall over time, confounding the goal of dietary supplements popular in anti-aging circles.
statnews.com
Sebastião Salgado, Acclaimed Brazilian Photographer, Is Dead at 81 www.nytimes.com/2025/05/23/a...
Sebastião Salgado, Acclaimed Brazilian Photographer, Is Dead at 81
nytimes.com
The reprogramming arms race-is it good for biotech?
Endpoints News@endpts.com · last yr.Longevity startup Retro Biosciences working on personalized blood disorders seeks $1b in funds.
While this is an interesting study in the morphology and heterogeneity of so called senescent cells by various inducers In vitro-what would be nice is to identify these cells in vivo in a disease tissue www.science.org/doi/10.1126/...
Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts
Single-cell morphologies reveal functional subtypes of senescence.
science.org
www.fiercebiotech.com/research/nih...
NIH tightens reins on subawards, ending the process for foreign recipients
The National Institutes of Health is making a major change to how grant recipients can use their funds. | The National Institutes of Health is making a major change to how grant recipients can use the...
fiercebiotech.com
Xenopus leads the way-5-Formylcytosine is an epigenetic mark for RNA Pol III during zygotic reprogramming: Cell www.cell.com/cell/fulltex...
5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming
An open question in epigenetics is if 5-formylcytosine (5fC) is merely a byproduct of active demethylation or an instructive mark that regulates gene expression on its own. This work demonstrates 5fC ...
cell.com
