Huge congratulations to Angeliki Chalasti @angelikichalasti.bsky.social on her successful PhD viva on linking zeolite physical and chemical properties to powder flow behaviour! Massive thanks to the examiners Dr. Colin Hare and Prof. Ronny Pini. 🎉👏

Congratulations to Lok Hang Wong for his three talks at the 2025 #AIChEAnnual Meeting on using population balance modelling for lysozyme crystallization! Topics included protocol development for data acquisition, proposing rate expressions & deploying a calibrated model for design space exploration🎉

Congratulations to Izabela Phillips on the successful completion of her PhD and viva, which investigated the impact of particle attributes on pharmaceutical powder tabletability. A huge thank you to Prof. Jerry Heng for his supervision, and to the examiners, Prof. Rongjun Chen and Dr. Colin Hare.👏

Congratulations to Lok Hang Wong for passing his PhD Early Stage Assessment (ESA) yesterday, focusing on using process modelling to optimize & accelerate the adoption of crystallisation techniques for purifying proteins and peptides!🎉Many thanks to Dr Antonio Del Rio Chanona for being the assessor!

Welcome to @henggroup.bsky.social Priyam Chakraborty @priyam-cif.bsky.social! Priyam is from India & did his masters project on small molecule crystallisation at IIT Hyderabad. He now works on the Marie Curie DN project PROCRYSTAL focusing on impurity effects on monoclonal antibody crystallisation.

Check out our new paper on crystal regeneration💎We report regeneration with multiple breakage sites, regeneration growth kinetics and regeneration's potential to improve process productivity and cost efficiency: pubs.acs.org/doi/full/10.1021/acs.cgd.5c00806 Congratulations Deniz Etit and Isha Bade!

Post-breakage Crystal Regeneration: Multiple Breakage Sites, Growth Kinetics, and Effects on Mass Production

Post-breakage crystal growth is obscure. Recently, form I paracetamol (PCM) crystals, broken to expose their internal cleavage plane (010), grew back into their original shapes through “regeneration.”...

pubs.acs.org

Huge congratulations to Shuning Xiang @shuning-x.bsky.social for passing her PhD viva on the development of nanoporous packaging for improving stability & pulmonary delivery of vaccine formulations, co-supervised by Prof. Rongjun Chen! Big thanks to examiners Dr Fan Zhang & Dr Yuval Elani.🎉👏

Hi! I am Adam Ismail, a 3rd-year ChemEng undergrad from MJIIT, UTM visiting @henggroup.bsky.social. I am researching moisture sorption and drying of food powders using DVS and particle analysis. I am passionate about food science, materials, and London! ⚗️

Hi! I am Fanqi Gong, a 3rd year undergraduate student of @Imperialchemeng.bsky.social currently doing my UROP in @henggroup.bsky.social. My project focuses on performing automation of solubility measurement and crystallisation of GLP-1 analogues.

Delighted to share that Isha Bade has been awarded the BACG Young Scientist Award 2025 by the British Association for Crystal Growth, for her publication on the 'Regeneration' phenomenon of crystals post breakage. Huge congratulations Isha! 👏🎉 share.google/JjonWxjhzwWT...

Deniz Etit recently presented his work on post-breakage crystal regeneration at the Annual Conference of the British Association of Crystal Growth (BACG) in Leeds, UK, which was very well-received! 💎 Congrats Deniz!

Last month Isha Bade presented her poster on crystal regeneration post-breakage at the 7th David Grant Symposium in Minnesota, highlighting a unique “facet switch-off” behaviour observed during regeneration where crystals appear to exhibit shape memory. Congrats Isha👏#CrystalGrowth

Check out fresh new work from @danielepessina.bsky.social pubs.acs.org/doi/10.1021/... - We developed an experimentally-validated black-box compatible uncertainty quantification methodology, tailored to protein crystallisation systems with sparse measurements.👏

Integrated In Vitro/In Silico Uncertainty Quantification Method for Protein Crystallization Models

The complexity of protein crystallization and in silico modeling challenges process intensification and the wider adoption of crystallization in biomanufacturing. For computational models to support and replace extensive experiments, they must accurately reflect in vitro experiments. However, parameter estimation can be ineffective due to the highly nonlinear model structure and inaccurate online process analytical technology, which must be addressed. In this work, an experimentally validated and model-driven parametrization methodology is presented, developed for an antisolvent batch protein crystallization system with limited offline measurements. Global sensitivity analysis is performed to assess parameter identifiability during batch operations and inform optimal measurement points. Experiments at three different initial lysozyme concentrations (c0 = 15, 18, 19 mg/mL) are used for estimation. Parameter uncertainty distributions are recovered through an Approximate Bayesian Computation algorithm and propagated to model outputs through Monte Carlo simulations, avoiding linearization or unnecessary assumptions on the parametric and output uncertainty distributions. The methodology was successfully validated under two new experimental conditions. The shapes of the recovered parametric and output uncertainties highlight the need for parameter estimation methodologies specifically tailored to nonlinear models.

pubs.acs.org

Deniz Etit recently attended the 7th David Grant Symposium in Minneapolis, USA and presented his novel findings on post-breakage crystal growth and regeneration, which was very well-received! 💎 Congrats Deniz!

Congratulations to @jianingli01.bsky.social for passing her PhD Late-Stage Review on the effect of protecting groups on the solubility & crystallisation of short-chain peptides. A massive thank you to Prof. Rongjun Chen for being the assessor and the informative discussion! Very well done Jianing!👏

Welcome to @henggroup.bsky.social Hirokatsu Yoshioka! Hirokatsu is a PhD student at @imperialchemeng.bsky.social, working on the PROCRYSTAL project. Originally from Japan, he joined us last summer for a 2-month project on paracetamol. He will now study cyclic peptide crystallisation like vancomycin.

Hi, I am Jiangying Xu, a Chemical Engineering MSc student @imperialchemeng.bsky.social currently working on my research within @henggroup.bsky.social. My research project focuses on crystal regeneration 😊

Huge congratulations to all the graduates from yesterday’s ceremony, and a special shoutout to our @henggroup.bsky.social PhD graduates: Enshu, Ethan, Isha, and Tsaone! 🎉🎓 We’re incredibly proud of you and thrilled to celebrate your achievements together! @imperialchemeng.bsky.social

Hi, I am Leila Kulenovic, a new MSc student @imperialchemeng.bsky.social working in the @henggroup.bsky.social.😊 I am from California and I completed a BSc in Chemistry at UC Santa Barbara. My research will expand on the use of absorbents as superhydrophobic materials for oil-water separations.

Hi, I am Chester Zheng, an MSc @imperialchemeng.bsky.social student in the @henggroup.bsky.social! I am from China, and my research within the group focuses on the optimisation of crystal regeneration post breakage. Outside of research, I am also interested in badminton and video games. 😊

@angelikichalasti.bsky.social recently presented her PhD research on the relationship between zeolite particle properties and powder flowability at the Johnson Matthey Academic Conference (JMAC) 2025, held at the University of Warwick. Congratulations Angeliki!👏@imperialchemeng.bsky.social

Many congratulations to Angeliki Chalasti @angelikichalasti.bsky.social for being awarded the 2nd Prize for the Votes Award for Best Oral Presentation at the 2025 Chemical Engineering PhD Symposium @imperialchemeng.bsky.social for her talk on the physicochemical and flow properties of zeolites.👏

Many congratulations to Isha Bade for being awarded the 2nd runner-up for the Judges' Award for Best Oral Presentation at the 2025 Chemical Engineering PhD Symposium @imperialchemeng.bsky.social, for her talk on crystal regeneration - a fascinating phenomenon observed in crystals after breakage.👏

Huge congratulations to Hamish Mitchell for passing his PhD viva this week! In his PhD Hamish investigated seeding-based workflows for the crystallisation of pharmaceutical peptides. Big thanks to examiners Prof. Sarah Hudson and Prof. Nilay Shah.🎉👏

@danielepessina.bsky.social recently presented at the American Chemical Society Meeting, in San Diego his work on uncertainty quantification of crystallisation models, and the design space identification of template-induced crystallisation processes. Well done Daniele!👏@imperialchemeng.bsky.social

Deniz Etit recently attended the BASF-IConIC Retreat 2025 at the Cumberland Lodge in Windsor, UK and presented his work on shape control of needle-like crystals for industrial applications, which was well-received! 💎 Congrats Deniz!

Great to see @jianingli01.bsky.social presenting her PhD work on the effect of protecting groups on solubility and crystallisation of alanine homopeptides at the EPI 2025 - XIX Iberian Peptide Meeting in Santiago de Compostela, Spain. Very well done!👏🎉

We were delighted to host Prof. Mikio Yoshida from Doshisha University @henggroup.bsky.social at @imperialchemeng.bsky.social.😊 His visit sparked insightful discussions including lab tours and research presentations showcasing our ongoing research work in crystallisation and particle properties.

Our @henggroup.bsky.social celebrated the start of 2025 with our first group dinner of the year!😊A great chance to reconnect & enjoy good food together. Moments like these remind us the value of teamwork & shared goals. Here’s to a productive & collaborative year ahead!✨@imperialchemeng.bsky.social