@pk-liu.bsky.social
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
Excited to share our latest work on Analytical Chemistry, introducing a novel 13-plex DeAla isobaric tag for improved peptide fragmentation, enhanced protein identification, and competitive pricing 🥳🥳🥳 Congrats to @pk-liu.bsky.social and co-authors ✨✨ pubs.acs.org/doi/10.1021/...
13-Plex DeAla Isobaric Reagents for High-Throughput Proteome Quantification
Isobaric labeling techniques are widely used in mass spectrometry-based quantitative proteomics to enable the simultaneous analysis of multiple samples. However, commercial isobaric tags are expensive...
pubs.acs.org
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini
Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...
rdcu.be
Check out our latest review, featuring recent advances in chemical labeling strategies, including activity-based protein profiling (ABPP), proximity labeling (PL), and proteolysis-targeting chimeras (PROTACs) 🥳🥳🥳 Congrats @pk-liu.bsky.social and Zicong 🎉🎉 Link: doi.org/10.1016/j.cb...
