Tessera

Yeqiao Zhou

@yeqiaoz.bsky.social

Yeqiao Zhou @yeqiaoz.bsky.social · 9mo ago

Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social tinyurl.com/4nwfbeu2 tinyurl.com/4zaw5cn7 tinyurl.com/25snbf4j

OLIVE provides rapid visualization and analysis of chromatin tracing experiments

Zhou et al. develop the optical looping interactive viewing engine (OLIVE), a web-based application for browsing and exploring user-generated and publicly available chromatin tracing datasets.

cell.com

Golnaz Vahedi @vahedilab.bsky.social · 9mo ago

Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology

Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...

nature.com

Golnaz Vahedi @vahedilab.bsky.social · 9mo ago

I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in @sciimmunology.bsky.social scim.ag/4o12TOZ

Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes

Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.

scim.ag