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Faryabi Lab @UPENN

@faryabi.bsky.social

Interested in epigenetics, cancer biology, and learning!

2 Posts191 Follower60 Folgt
Yeqiao Zhou@yeqiaoz.bsky.social · 8mo ago

Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social tinyurl.com/4nwfbeu2 tinyurl.com/4zaw5cn7 tinyurl.com/25snbf4j

OLIVE provides rapid visualization and analysis of chromatin tracing experiments

Zhou et al. develop the optical looping interactive viewing engine (OLIVE), a web-based application for browsing and exploring user-generated and publicly available chromatin tracing datasets.

cell.com

Golnaz Vahedi @vahedilab.bsky.social · 8mo ago

Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology

Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...

nature.com

Faryabi Lab @UPENN@faryabi.bsky.social · 8mo ago

Kudos to Yeqiao Zhou, @atishayjay.bsky.social, and @vahedilab.bsky.social for our new @natcellbio.nature.com study www.nature.com/articles/s41...! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology

Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...

nature.com