Chaitanya Chintaluri

@chaichinta.bsky.social

Food, neurotheory, and everything in between.

1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .

A mitochondrion showing Ca2+ entering through the MCU, exchanged for Na+ by NCLX, Complex I acting as a Na+/H+ exchanger, and various transporters that use Na+ to move their substrates in and out of the mitochondria

Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:

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I think if you grabbed any famous thinker from centuries ago and showed them Wikipedia and told them it was free for anyone to access, they would say it is humanity's crowning achievement and would be indifferent to the moon landings, modern medicine, flight, or anything else you showed them