1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .
Chaitanya Chintaluri
@chaichinta.bsky.social
Food, neurotheory, and everything in between.
If Elon Musk, donated $4 to every star in the Milkyway galaxy, he would still be a billionaire.
"How do YOU know prayers don't work?" Larry David: "Because I'm bald."
Coriander chutney (coriander, ginger, green chili, sugar, salt and roasted chana dal/dalia) is a supreme pesto substitute. ONO.
When you connect with the 8th-century CE diss track throwing some shade on Bṛhaspati ...
'The book of the dead' has (what looks like) a TL;DR summary at the top of each page. The book itself is a cheat sheet of spells one took into the afterlife. #PapyrusMuseumVienna
"Fig. 2 shows a representative experiment"
The science literature used to be more fun
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
Time for the world to install a gigawatt of solar power capacity 2004: A year 2010: ~ a month 2015: ~ a week Now: A day ourworldindata.org/data-insight... 🧪
Classical music: "Oh! I see it now!" Jazz: "yes! I know right... ... !"
"Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer" www.biorxiv.org/content/10.1...
MitoTracker transfers from astrocytes to neurons independently of mitochondria
The neuroprotective transfer of mitochondria from astrocytes to neurons has been primarily investigated by labelling astrocytic mitochondria with the dye MitoTracker. Here we report that MitoTracker transfers to neurons from both astrocytes and astrocyte-conditioned media, independently of mitochondrial transfer. Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer and in other systems in which contact-independent transfer has been observed using mitochondrial dyes. ### Competing Interest Statement The authors have declared no competing interest. MSD (United Kingdom), https://ror.org/004nn4n27, PRJ_20446 DEVINE MSD MRC The Francis Crick Institute, https://ror.org/04tnbqb63, CC2206
biorxiv.org
"Doubt thou the stars are fire, Doubt that the sun doth move, Doubt truth to be a liar, But never doubt I love." Love for dosa I'm sure.
NEW ANALYSIS: UK's solar power surges 42% to a new record, after the sunniest spring on record * For the first time, solar was >10% of UK generation in consecutive months (April/May 2025) * In 2025, solar has already avoided gas imports that would've cost £600m www.carbonbrief.org/analysis-uks...
I think if you grabbed any famous thinker from centuries ago and showed them Wikipedia and told them it was free for anyone to access, they would say it is humanity's crowning achievement and would be indifferent to the moon landings, modern medicine, flight, or anything else you showed them
Chole-batura that I made. The batura was mid. The chole was slay. And no - I didn't use the fork and knife.
I collaborated with a friend of mine and did an Indo-Italian fusion menu at a Heuriger (a tavern) in lower Austria.
Kimchi is Korean <Achar>. Bibimpap is Korean <Thali>