Excited to see this work online. 🌟Huge thanks to all collaborators and lab members for their support and contributions 🎉👏

Molecular Cell@cp-molcell.bsky.social · 4mo ago

Online Now: Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes Online now:

Our new preprint is now on BioRxiv! Very excited to share this this work. Come take a look at what we have been working on! 😊

Simon Bekker-Jensen lab@bekkerjensenlab.bsky.social · 10mo ago

New preprint out! Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...

New preprint out! Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...

ZAKα is a sensor of mRNA stasis at the ribosomal exit channel

Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...

biorxiv.org