✨ Excited to share our latest story, now online! 🧬 We investigated how ZAKα senses stalled and collided ribosomes in the ribotoxic stress response. Huge thanks to members of @cgen2025.bsky.social and all excellent collaborators who contributed to this work.👏 Congratulations to everyone involved!🎉

Molecular Cell @cp-molcell.bsky.social · 3mo ago

Online Now: Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes Online now:

New group photo for 2026! ✨🌟Kicking off the year with frozen-lake walking and a snowball fight❄️☃️. And most importantly, Happy Birthday to our great PhD student @josefcomh.bsky.social

Huge congrats to our brilliant postdocs, @catarinapechincha.bsky.social and @sofiaramalho.bsky.social on both being awarded EMBO Postdoctoral Fellowships @embo.org ! This is a major milestone for the group and truly one of the best Christmas gifts we could receive.🎉🎉🎉

New preprint out! Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...

ZAKα is a sensor of mRNA stasis at the ribosomal exit channel

Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...

biorxiv.org

I am happy to share the latest paper from the lab. We detail a tripartite cell-free translation system based on the separation of mRNAs, ribosomes and ribosome-depleted cytoplasmic lysate from human cells, allowing for flexible reconstitution of translation reaction. #RNA #Ribosome

Nature Protocols@natprot.nature.com · last yr.

New Article! A tripartite cell-free translation system to study mammalian translation

Congratulations @ribocode.bsky.social team on our review published today @royalsociety.org Awesome team work to write this as such a large group. royalsocietypublishing.org/doi/10.1098/...

Specialized ribosomes: integrating new insights and current challenges | Philosophical Transactions of the Royal Society B: Biological Sciences

Variation in the composition of different ribosomes, termed ribosome heterogeneity, is a now well established phenomenon. However, the functional implications of this heterogeneity on the regulation of protein synthesis are only now beginning to be ...

royalsocietypublishing.org

It's not all DNA: Also RNA damage contributes to cellular stress! RNA lesions trigger ribosome stalling, which can influence cell fate. Very nice review (for me as an RNA damage muggle) from @jstingele.bsky.social doi.org/10.1016/j.ce... 🧪

Enjoying a great Gordon Research Seminar in California ☀️ presenting our science and discussing with wonderful collaborators such as Franklin Zhong from NTU Singapore 🙌 #GRC #Gordonconf #ribosome

Another opportunity to join CGEN: we are seeking 2 or more Postdocs 🧬🧪 Deadline March 18, 2025 Please share with your relevant networks! employment.ku.dk/faculty/?sho...

Postdoc in gene expression

employment.ku.dk

Looking for a PhD position? Have a look at these PhD fellowships at our center 🧪☀️🇩🇰 (and also: follow our Center for Gene Expression @cgen2025.bsky.social for more news in the future 🤗 )! #PhDposition @ucph.bsky.social

Center for Gene Expression (CGEN)@cgen2025.bsky.social · last yr.

💥 CGEN is hiring 💥 We are looking for 2 or more highly motivated PhD students to join our DNRF Center of Excellence, Center for Gene Expression (CGEN) at University of Copenhagen. Deadline: March 6, 2025 Please share with your relevant networks! employment.ku.dk/phd/?show=16...

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.   Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

🚨The triennial Ribosome Conference will be held June 22-June 27, 2025 in Pacific Grove, California. Registration is open - hope to see many #Ribosome #RNA aficionados there. #RNASky #AcademicSky 🧪 rna.ucsc.edu/rnacenter/ri...

Great opportunity 👇

The Groth lab@grothlab.bsky.social · 2y ago

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

Postdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...

Postdoc positions in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet

Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet

mbg.au.dk

New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology @molbiolau.bsky.social mbg.au.dk/en/news-and-...

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

"first thing the cells respond to after being exposed to UV radiation is damage to the RNA, and that this is what triggers cell death and inflammation of the skin" via the ZAK gene. phys.org/news/2025-01...

Damage to RNA, not DNA, found to be main cause of acute sunburn

We have all been told to avoid direct sunlight between 12 noon and 3 p.m., seek out shade and put on sunscreen and a hat. Nevertheless, most of us have experienced sunburn at least once. The skin turn...

phys.org

Okay, the list is far from complete, but it is a first attempt.☺️Here you can find our starter pack on #research organizations and #academies, in #Germany and worldwide. Who else do you think should be included? go.bsky.app/DGGtVu6

Damage to RNA, not DNA, found to be main cause of acute sunburn

Damage to RNA, not DNA, found to be main cause of acute sunburn

We have all been told to avoid direct sunlight between 12 noon and 3 p.m., seek out shade and put on sunscreen and a hat. Nevertheless, most of us have experienced sunburn at least once. The skin turn...

phys.org

#RNAsky #ribosomes Take notice!

Liam Faller@liamfaller.bsky.social · 2y ago

The end of the year is a good time for a bit of appreciation: I work with a wonderful group of people. There will be some big lab news coming soon, but before then, here's a review we published earlier this year. academic.oup.com/narcancer/ar... #RNAbiology

1/2 We’re hiring a Postdoc to join us at the University of Copenhagen. Are you fascinated by 3D chromatin function and super-resolution microscopy? Then this might be the job for you. Start date 1st of April 2025, starting salary 4700 Euro/month. Apply here: candidate.hr-manager.net/ApplicationI...

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ALT: a green background with red circles and a green circle in the middle

media.tenor.com

Are you: - Scientifically curious and determined to pursue a PhD degree? - Eager to work on interdisciplinary research projects related to cancer or neurological diseases? - Driven to strengthen your scientific creativity and independent thinking? www.linkedin.com/feed/update/...

Biotech Research & Innovation Centre (BRIC), University of Copenhagen on LinkedIn: How to apply

🌟 CALL FOR PHD APPLICANTS 🌟 Københavns Universitet - University of Copenhagen and DTU - Technical University of Denmark are excited to announce up to 22…

linkedin.com

⚡️Now online⚡️: Our review on how ZAKa and #ribosomes regulate cell death when things go bad ☠️ 🧪 @cellpress.bsky.social @annaconstancevind.bsky.social 👏 ⬇️

Anna Constance Vind@annaconstancevind.bsky.social · 2y ago

✨ Our latest review is now online! ✨ Read about #ZAKa and #ribosomes roles in cell death triggered by: 1️⃣ Environmental and endogenous stressors 2️⃣ Plant and microbial toxins 3️⃣ Celluar pathways leading to self-inflicted ribotoxicity @bekkerjensenlab.bsky.social 🙏 👇 www.cell.com/trends/cell-...

🎄We had a great time at our Christmas lunch with many delicious dishes from all over the world 🌍 🦪🥗 🌟 Perfect opportunity to appreciate the different cultures in the group 🎊

Thanks to the Molecular Biology Society of Japan for a wonderful meeting in Fukuoka and to the organizers for their exceptional hospitality 🎌 🎏

✨Back from an inspiring institute retreat! Thanks to all participants and organizers for putting together this exciting program and to Minik Rosing for a wonderful talk about life on our planet 🌍 🌿 @josefcomh.bsky.social @zhenzhenwu.bsky.social @annaconstancevind.bsky.social @melacular.bsky.social

Looking forward to enjoying the full taste of RNA! www.embl.org/about/info/c...

The expanding world of RBPs: from posttranscriptional control to riboregulation

embl.org

Time for our first post here 🥳 Our latest paper is online 🙌 We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

cell.com

Are you a scientist working or interested in RNA Translation? Join our starter pack and share ideas, methodologies and tips to advance our knowledge in how life came to be! #RNA #ribosome go.bsky.app/VN78eTo

All you want to know about ribosome(s)

Robert Arkowitz@robertarkowitz.bsky.social · 2y ago

www.cell.com/cell/fulltex...

🚨 Update for #RNA science fans: I checked on #Bsky registry, and here is a 'condensate' (😆) of all #RNA #RNAsky starter packs so far: 1. General RNA biology #1 go.bsky.app/RN6HnZp