Fried Lab JHU

@friedlab.bsky.social

Asst. Prof of Chemistry🧪 & Biophysics 🧬 at JohnsHopkins; unofficial lab rabbi ✡️; ally 🏳️‍🌈; #TeamMassSpec. PI of structural proteomics/protein folding/ageing research lab.

Wouldn’t have been possible without the indefatigable @leunglab.bsky.social a brilliant co-organizer! Very pleased the day was such a success. Special Thanks to student speakers who really took things up a notch!

Anthony Leung@leunglab.bsky.social · last yr.

What a fantastic day of science at FCBIS! @friedlab.bsky.social and I had a blast co-organizing this exciting dive into the chemistry-biology interface—great conversations, amazing energy, and a standout keynote by @edwardmarcotte.bsky.social. Thanks to all who joined us!

Excited to share some work in our collaboration between @fried_lab and Ed O'Brien @psu_chemistry, just published in @ScienceAdvances : www.science.org/doi/10.1126/.... Here we describe the structural basis for stretched exponential kinetics in protein folding. A thread.

Protein misfolding involving entanglements provides a structural explanation for the origin of stretched-exponential refolding kinetics

Protein misfolding involving entanglements could be the structural origin of power-law distributions of folding times.

science.org