🤔 How do mechanical forces shape the behavior and organization of living matter? 👩‍🔬Understanding how these forces influence material properties, molecular composition, and biological function is a key focus of the @fischerfriedriclab.bsky.social at Physics of Life. Learn more👉 youtu.be/1bzjPVxlAf4

Starting our second phase at Physics of Life Dresden full of energy! ⚡️But who are we, and what is our research about? 🎥We are releasing a series of exciting short films to answer these questions and more 🎬 Curious? Check them out🤓 Full video on YouTube: www.youtube.com/watch?v=nHm6... Part 1/2

Here's a beautiful #microscopy image from our PoL Photo Competition 📸 👨‍🔬 🔬©️ Image taken by Yogishree Arabinda Panda, PhD student in the Fischer-Friedrich group @fischerfriedriclab.bsky.social 🔍 Caption: A SEM micrograph of a mitotically arrested HeLa cell with visible filopodia membrane reservoirs

#jobalert - We are looking for an experimental #Postdoc to join our group and work on exciting questions in #Mechanobiology - prospectively starting 09/2026. The ideal candidate has experience in #microscopy, quantitative image analysis, coding. Get in touch if you would like to know more.

Just published: chemotactic sperm cells become phototactic 💡- by loading photo-activatable second messengers. This allows to "reverse-engineer" chemotactic signaling dynamics and expose cells to signals they would never see in the wild. Honoured to be part of this collaboration with the Kaupp lab.

ECM as a cell-cycle brake. Led by Liyuan Sui (Dahmann lab), we show that the ECM gates Yorkie nuclear entry to halt proliferation at final size via G2 arrest in the Drosophila wing disc. Programmed ECM degradation later enables re-entry + proper adult wing size. Link 👇 #Mechanobiology #ECM

New paper out: AFM-tip fluctuations inside the actin cortex reveal that effective temperature can remain unchanged while time-irreversibility/entropy production drop (turnover inhibition). #CellMechanics #ActiveMatter #Nonequilibrium @poldresden.bsky.social @tudresden.bsky.social

New paper out: AFM-tip fluctuations inside the actin cortex reveal that effective temperature can remain unchanged while time-irreversibility/entropy production drop (turnover inhibition). #CellMechanics #ActiveMatter #Nonequilibrium @poldresden.bsky.social @tudresden.bsky.social

🏋️Our review on how to build muscle is out in @biophysicalreviews.bsky.social: The Physical Basis of Sarcomere Assembly. We critically review past models and discuss a new mechanism that unifies past ideas, suggesting tension-driven self-organization. With @frankschnorrer.bsky.social & Kolley-Köchel

Axolotl can regrow lost limbs, matching their body size. How? Our new theory-experiment paper in @pnas.org proposes how oppositely oriented morphogen gradients scaling with animal size promote proportional growth. Great collaboration with @tatianasg.bsky.social @cmcb-tud.bsky.social

Interested in #mechanobiology? I joined Bruker’s Conversations on AFM to discuss how mechanical forces shape #cells and #tissues, what #AFM can reveal, and why mechanics matters for health and disease. @poldresden.bsky.social @tudresden.bsky.social

Congrats to our latest graduate Gina Dimari 🤩🥳💐@fischerfriedriclab.bsky.social @poldresden.bsky.social freshly graduated @tudresden.bsky.social faculty of Biology. Thanks to everyone involved in the project recently published @cp-iscience.bsky.social

How do individual proteins sculpt the epithelial basement membrane? Our new study uncovers their role in network structure, nematic alignment & fractal patterns. 🔗 www.sciencedirect.com/science/arti... #CellBiology #ECM #BasementMembrane

Why do secondary #tumors go for #MET during the metastatic cascade? Our new study suggests that immune evasion—rather than faster proliferation—might give them the edge. 👉 cell.com/iscience/ful... #CancerResearch #TumorBiology #Immunology #Metastasis

Mesenchymal-epithelial transition reduces proliferation but increases immune evasion in tumor spheroids

Microenvironment; Biological process; Cancer

cell.com

🎉 Calling all #Physics undergrads! We're offering 3 scholarships for the tuition-free, English-taught MSc "Physics of Life" @TUDresden, starting Oct 2025. 💶 €300/month for 12 months Apply now! #Scholarships #Masters2025 #PhysicsOfLife #StudyInGermany #TUDresden

Super proud of superstar postdocs @nerlielisa.bsky.social and @liujinghui.bsky.social for our lab's most recent preprint! We uncover how wound-induced electrical currents are generated and transmitted in tissues, triggering proliferation, essential for organ #regeneration #bioelectricity #QBio 👇

Elisa Nerli@nerlielisa.bsky.social · last yr.

How can organs regenerate fast? Bioelectricity helps -- by coupling sub-second electrical injury signals to regenerative proliferation. First preprint from my potsdoc :D with @liujinghui.bsky.social @ritamateus.bsky.social @mpi-cbg.de and collaborators @mpipks.bsky.social @csbdresden.bsky.social

📢 Preprint alert 📢 (1/6) Our work on 3D force inference for intestinal organoids is now on bioRxiv: www.biorxiv.org/content/10.1... Stunning collaboration between @omdrozdowski.bsky.social and @kimboonekamp.bsky.social from the lab of @michaelboutros.bsky.social and with Ulrike Engel. A short🧵...

🚀 Looking for a Master’s at the interface of physics and biology? Join the Physics of Life MSc program in Dresden! 🔬 Cutting-edge research 🌍 Affordable living 🎯 Excellent career prospects—in science and beyond.

Surprised by how long it’s taking PNAS to process our manuscript. Anyone else having trouble recently? #AcademicTwitter #Publishing

It’s the #filopodia, stupid! 🚀 We just released our new study uncovering how filopodia and hydrostatic #pressure contribute to the regulation of #membrane #tension. 👉 Check it out on bioRxiv: biorxiv.org/content/10.1... #cellbiology #biophysics #actin #mechanobiology

🚀 Looking for an #HFSP ally? We’ve got you covered with #AtomicForceMicroscopy, #CellCulture, #Mechanobiological #Modeling, & more! 🤝 Interested? Let’s connect! 📧 Details 👉 physics-of-life.tu-dresden.de #Collaboration

It turns out that #EggChamber #elongation and rotation can be decoupled in #Drosophila egg chamber #morphogenesis - check out our recent collaborative work with the Dahmann lab. journals.biologists.com/dev/article/... . Congrats to Akanksha Bhatt and Valentin Ruffine 👏🥳