SYNBRIDGE: A VERSATILE FRAMEWORK FOR BIDIRECTIONAL INTERCONVERSION BETWEEN BIOBRICKS AND GOLDEN GATE ASSEMBLY STANDARDS https://www.biorxiv.org/content/10.64898/2026.10.16.759639v1

PiggyBac transposon and transposase delivered in trans, in cis, and as mRNA for engineering CAR-T cells: a multi-objective optimization https://www.biorxiv.org/content/10.64898/2026.10.16.758153v1

Engineering the effector specificity of the macrolide-sensing transcription factor MphR for the detection of sesquiterpenes https://www.biorxiv.org/content/10.64898/2026.10.16.759199v1

Exploring the Design Space of 310-helical Bundles using Non-canonical Amino Acids https://www.biorxiv.org/content/10.64898/2026.10.16.759603v1

Discovery of a Novel High-Salt-Adapted Archaeal AP Endonuclease using Microfluidics-Based Cell-Free Functional Metagenomics https://www.biorxiv.org/content/10.64898/2026.10.16.759439v1

Selective Recognition, Covalent Linkage and Chemical Exchange of Artificial Cells through Engineered α-Hemolysin https://www.biorxiv.org/content/10.64898/2026.10.16.759538v1

Synthetic biology-guided modular engineering of the secreted cutinase FoCut5a with a carbohydrate-binding module improves poly(ester-urethane) depolymerization in Yarrowia lipolytica https://www.biorxiv.org/content/10.64898/2026.10.15.759203v1

De novo design of metalloenzymes using Metal Mer https://www.biorxiv.org/content/10.64898/2026.10.13.758590v1

Ice drives the emergence of functional protocells https://www.biorxiv.org/content/10.64898/2026.10.13.758973v1

Self-extending DNA recording with stochastic and programmed writing https://www.biorxiv.org/content/10.64898/2026.10.14.759016v1

Fungal Highways Enable Underground Biosensors https://www.biorxiv.org/content/10.64898/2026.10.14.758573v1

Generative design of functional disordered regions in a developmental transcription factor https://www.biorxiv.org/content/10.64898/2026.10.12.757977v1

Archival data storage using DNA proximity graphs https://www.biorxiv.org/content/10.64898/2026.10.12.758707v1

Engineered cells that sense and respond to interleukin-23 with neutralizing therapy for autoimmunity https://www.biorxiv.org/content/10.64898/2026.10.12.758578v1

Programming Targeted Immune Cell Migration Using Orthogonal Chemokine-Receptor Pairs https://www.biorxiv.org/content/10.64898/2026.10.12.758398v1

Computational design of protein conformational landscapes for metamorphic behavior https://www.biorxiv.org/content/10.64898/2026.10.13.758820v1

Mapping Synthetic Circuit Design Space through Massively Parallel Measurement of Single-Cell Dynamics https://www.biorxiv.org/content/10.64898/2026.10.11.758309v1

Giant Vesicle Platform for Synthetic Endoplasmic Reticulum Networks https://www.biorxiv.org/content/10.64898/2026.10.10.756113v1

How Bacterial Growth-Phase Reshapes Synthetic Gene Circuit Function https://www.biorxiv.org/content/10.64898/2026.10.09.752898v1

Modular Cell-Free Extract Mixing Enables Soluble, Active Biomanufacturing of Difficult-to-Express and Aggregation-Prone Proteins https://www.biorxiv.org/content/10.64898/2026.10.09.757855v1

High-throughput variant libraries and machine learning enable robust target-site selection for toehold-switch design in Detectrons https://www.biorxiv.org/content/10.64898/2026.10.09.758053v1

High-throughput in vivo DNA data encoding by multiplexed conjugationand orthogonal base editing https://www.biorxiv.org/content/10.64898/2026.10.08.757515v1

Sense-and-response to intracellular signaling via nucleocytoplasmic localization control of a synthetic transcription factor platform https://www.biorxiv.org/content/10.64898/2026.10.07.757469v1

Directed evolution of a thermostable family-A DNA polymerase into a reverse transcriptase for 2'-modified RNA https://www.biorxiv.org/content/10.64898/2026.10.08.757645v1

VesiScope: A stand-alone tool for the automatic detection, quantification and size analysis of GUVs from phase contrast microscopy images https://www.biorxiv.org/content/10.64898/2026.10.08.757674v1

Certified Design Regions under Parametric Plant Uncertainty with Application to Antithetic Integral Feedback https://www.biorxiv.org/content/10.64898/2026.10.08.757569v1

Releasing Protein Cargo from Synthetic Cells by Coupling Cell-Free Expression to Osmotic Actuation https://www.biorxiv.org/content/10.64898/2026.10.06.757017v1

SynBioCrow: provenance-preserving integration of complementary retrosynthesis engines for biosynthetic pathway design https://www.biorxiv.org/content/10.64898/2026.10.06.756997v1

PepRePs: Peptide-Retargeted Phosphatases Designed with Generative Language Models https://www.biorxiv.org/content/10.64898/2026.10.05.756719v1

Targeted tumor desialylation by engineered probiotic reprograms the tumor microenvironment to potentiate immunotherapy https://www.biorxiv.org/content/10.64898/2026.10.04.756258v1