Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies

Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al. investigate influenza-specific antibodies to obtain a deeper understanding of how inherited differences influence the response. Their results highlight population vulnerabilities that could be mitigated in the design of globally protective vaccines.

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