Stefan Marciniak

@profmarciniak.bsky.social

Professor of Respiratory Science University of Cambridge. Lung doctor. Fellow St Catharine’s College. Cell biology. Pleural medicine. Rare disease. Genetics. Lab webpage = https://www.cimr.cam.ac.uk/staff/professor-stefan-marciniak

When someone is found to have done something wrong by an undercover reporter, I find the defense ”but it was entrapment" to be rather peculiar. It’s simultaneously a confession of _wanting_ to do that wrong thing, while also being stupid too dim to realise they were being played.

In NSCLC with 𝘌𝘎𝘍𝘙 exon 20 insertions, first-line sunvozertinib led to longer progression-free survival than chemotherapy. The most common adverse events of grade 3 or higher were elevated creatine kinase, diarrhea, and anemia. Full phase 3 WU-KONG28 trial results: https://nej.md/4fQWMwa

This image contains an excerpt from the Research Summary "First-Line Sunvozertinib in NSCLC with EGFR Exon 20 Insertion Mutations" published in the New England Journal of Medicine. It features a diagram of a patient with NSCLC with EGFR exon 20 insertion mutations. Text includes patient statistics: 324 adults, median age 62, with gender breakdowns for Sunvozertinib and chemotherapy groups. Two treatment illustrations are shown: a Sunvozertinib bottle and a Carboplatin–Pemetrexed bottle, with patient numbers for each treatment group. A prompt to read the full Research Summary at NEJM.org sits at the bottom.

Spent the morning fixing Mrs M’s 13 year old Nespresso machine. Unlike my 16 year old Gaggia, which is often in pieces, this was a first for me and the machine. It appears Moulinex Nesspresso machines were not designed to be dismantled. Nevertheless, it’s working again. Here’s to another 13 years ☕️

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The lab annual punting picnic has become something of a tradition. It’s also customary for all new starters to learn to punt, and punt hey did. Bravo Jacky and Shayan. You passed the practical component of your lab induction 😄

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Thinking about all the pupils getting their GCSEs today, but particularly those at the Wells Academy in Nottingham, where I was a pupil back for my O levels when it was called Elliott Durham Comp. I still remember going up to school for those results 40 years ago.

Day 13 Iberian Peninsula: O final (quase) [the finale (almost)], Braga🇵🇹 Cocktails at Galleria 101: v good perfect Manhattan & interesting twist on the idea they call a Bronx Tasting menu at Esperança Verde. Wonderful! Forgive me for forgetting to photo every course 👌🇵🇹👨‍🍳 Strong recommendation+++

Stefan Marciniak@profmarciniak.bsky.social · 3w ago

Day 12 Iberian Peninsula: 🇪🇸 Lunch at Tapas Negra, Orense. Risotto de tomate seco, parmesano y albahaca + Torrezno de Soria frito, crema de manzana a la sidra y mojo argentino Dinner at Parador Hotel in Tui as night falls. Croquetas de mejillones con mahonesa de cilantro + Vieira al horno

Day 12 Iberian Peninsula: 🇪🇸 Lunch at Tapas Negra, Orense. Risotto de tomate seco, parmesano y albahaca + Torrezno de Soria frito, crema de manzana a la sidra y mojo argentino Dinner at Parador Hotel in Tui as night falls. Croquetas de mejillones con mahonesa de cilantro + Vieira al horno

Stefan Marciniak@profmarciniak.bsky.social · 3w ago

Day 11 Iberian Peninsula: Monforte de Lemos 🇪🇸 Lunch at Méson J.M. - Vieiras del Pacífico a la plancha (scallops with enough garlic that even I — virtually garlic-anosmic — could taste it 👌) then Rape à la Gallega (Monkfish) with glasses of Godello

Day 11 Iberian Peninsula: Monforte de Lemos 🇪🇸 Lunch at Méson J.M. - Vieiras del Pacífico a la plancha (scallops with enough garlic that even I — virtually garlic-anosmic — could taste it 👌) then Rape à la Gallega (Monkfish) with glasses of Godello

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Stefan Marciniak@profmarciniak.bsky.social · 4w ago

Day 10 Iberian Peninsula: Muros Lunch at A Muradana. Mejillones de la ria en escabeche con espárragos (muscle & asparagus) then Pulpo cocido de la ría, asado al horno con grelos y alioli de ajada a la gallega (roasted octopus) + a glass of Godello (h/t @davidfairen.bsky.social for wine suggestion)