Tessera

In a secondary analysis of a trial of docosahexaenoic acid (DHA) in pregnant women, Yan Ning Li and colleagues examine whether different genotypes of the FADS indel might influence the effects of a low or high DHA dose on the timing of birth🧪 #MedSky plos.io/4sfmkYp

Genotype-informed docosahexaenoic acid dosing based on the FADS Indel to reduce preterm and prolonged gestation: A secondary analysis of the ADORE randomized trial

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In this modelling study, Sun Kim and co explore whether #tuberculosis active case finding can be more efficiently targeted using local Mycobacterium tuberculosis immunoreactivity survey data, highlighting that it could substantially improve health impact & cost-effectiveness🧪 #MedSky plos.io/4AWsXCG

Potential health impacts and costs of active case finding guided by Mycobacterium tuberculosis immunoreactivity survey results in Blantyre, Malawi: A mathematical modeling study

In this modelling study, Sun Kim and colleagues explore whether tuberculosis active case finding can be more efficiently targeted using local Mycobacterium tuberculosis immunoreactivity survey data fr...

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In this cohort study, Zhengyang Zhu and colleagues developed a ML-derived cardiovascular-kidney-metabolic (CKM) #aging index that outperformed established biological age measures in identifying high-risk CKM profiles and predicting mortality🧪 #MedSky #AI #cardiovascular plos.io/4rTLHyv

A machine learning-derived aging index for risk stratification and mortality prediction in cardiovascular-kidney-metabolic syndrome: A retrospective cohort study

In this cohort study, Zhengyang Zhu and colleagues developed a machine learning-derived cardiovascular-kidney-metabolic aging index that outperformed established biological age measures in identifying...

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Nice to see the PLOS Medicine editors together in person for their team retreat/workshop! ☀️🙌 @alisonfarrell.bsky.social @acmdc.bsky.social @droutledge.bsky.social @helenlumbard.bsky.social

🚨In this systematic review and meta-analysis, Maureen Moyo-Chilufya and colleagues synthesize evidence from studies in children and adolescents examining differences in all-cause mortality by disability status. Higher mortality was found among children and adolescents with disabilities. 🧪 #MedSky

The association between disability and mortality among children and adolescents: A systematic review and meta-analysis

In this systematic review and meta-analysis, Maureen Moyo-Chilufya and colleagues synthesize evidence from more than 35 million children and adolescents to examine differences in all-cause mortality b...

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🔔 In this target trial emulation, Po-Huang Chen and colleagues compare outcomes between selective serotonin reuptake inhibitor (SSRI) and benzodiazepine users with solid tumors, and depression/anxiety. Patients receiving immune checkpoint inhibitors who initiated SSRIs had lower mortality. 🧪 #MedSky

Selective serotonin reuptake inhibitors and immune checkpoint blockade in solid tumors: A target trial emulation with pan-cancer transcriptomic analyses

In this target trial emulation, Po-Huang Chen and colleagues compare outcomes between selective serotonin reuptake inhibitor and benzodiazepine users with solid tumors and depression or anxiety and fi...

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📣In this RCT, Kavita Singh and colleagues evaluate a multicomponent quality improvement strategy for chronic cardiovascular disease care, in India. The intervention is feasible to implement, well accepted by patients and providers, and delivered with high fidelity across diverse settings. 🧪 #MedSky

Assessing a multicomponent quality improvement strategy for chronic care of cardiovascular diseases in India: The C-QIP randomized feasibility trial

Kavita Singh and colleagues evaluated a multicomponent quality improvement strategy for chronic cardiovascular disease care in India and found it was feasible to implement, well accepted by patients a...

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In this study of over 167,000 children in Wales, Saraid McIlvride and colleagues examine links between prenatal exposure to maternal depression, antidepressants, and later neurodevelopmental outcomes. Children exposed to maternal depression had higher rates of special educational needs. 🧪 #MedSky

Prenatal exposure to maternal depression and antidepressants and neurodevelopmental outcomes: A population cohort study

In this study of more than 167,000 children in Wales, Saraid McIlvride and colleagues examined how prenatal exposure to maternal depression and antidepressants relates to later neurodevelopmental outc...

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In this Policy Forum, Laura Magee and colleagues provide updated guidance for ‘inverted’ antenatal care, including optimal screening timepoints and the most accurate methods of screening. They also highlight recent advances in diagnostics and treatment, such as AI-assisted technologies. 🧪 #MedSky

The inverted pyramid of care in modern-day obstetrics

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In recognition of #WorldHeartDay, this Editorial by Manpreet Kaur discusses the opportunities and challenges of harnessing #cardiovascular data from smartwatches, which may be a powerful tool in informing equitable and actionable cardiovascular disease research 🫀 🧪 #CVD #MedSky plos.io/4xVyUNB

From wrist to research: Harnessing smartwatch data for equitable cardiovascular research

Cardiovascular disease is a leading cause of death, and progress in reducing mortality has stalled, calling for more research. In this Editorial, Manpreet Kaur discusses the opportunity for…

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In this prospective cohort study, Kanna Hayashi and colleagues examine whether encampment sweeps are associated with transitions out of homelessness among unhoused people who use drugs in Vancouver, Canada. Those exposed to sweeps were less likely to stop reporting homelessness over time. 🧪 #MedSky

Encampment sweeps and persistent homelessness among unhoused people who use drugs in Vancouver, Canada: A prospective cohort study

In this prospective cohort study, Kanna Hayashi and colleagues examine whether encampment sweeps, including the confiscation of personal belongings and forced displacement, are associated with transit...

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In this systematic review and meta-analysis, Oladipupo Olalere and colleagues examine across 34 studies how lifestyle interventions relate to reproductive and metabolic outcomes in women in PMOS, and find these to be associated with improved menstrual regularity and metabolic outcomes. 🧪 #MedSky

The effect of lifestyle interventions in women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis

Author summary Why was this study done? Polyendocrine metabolic ovarian syndrome (PMOS) is a common hormonal condition affecting up to around 10%–13% of women of reproductive age and is linked with...

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In this population-level quasi-experimental study, Luan Nguyen Quang Vo and colleagues assess the effects of a public-private mix intervention implemented in Viet Nam and designed to increase tuberculosis notifications, with the aim that it could ultimately increase treatment coverage. 🧪 #MedSky

Evaluation of the tuberculosis notification impact from an intermediary-facilitated public–private mix intervention in Viet Nam: A population-level quasi-experimental study

Using a population-level quasi-experimental study design, Luan Nguyen Quang Vo and colleagues assess the effects of a public-private mix intervention implemented in Viet Nam and designed to increase t...

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In an ecological and modelling study, Manman Chen, Wanzhou Wang and colleagues fing that infectious disease epidemics were linked to health workforce losses across 194 countries and territories from 1990-2019. The largest relative impacts were seen in low- and middle-income countries. 🧪 #MedSky

Global, regional, and national impact of epidemic disasters on health workforce equality between 1990 and 2019: An ecological and modeling study

Manman Chen, Wanzhou Wang and colleagues examined how infectious disease epidemics were associated with changes in the health workforce across 194 countries and territories from 1990 to 2019. Their fi...

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In this population-based study, Ernst Bergman and colleagues find that older adults receiving a health assessment and personalised counselling had a lower risk of type 2 diabetes. The findings suggest even low-intensity primary care interventions may help prevent diabetes. 🧪 #MedSky plos.io/4yQWpYO

Association of a multiple risk factor assessment and intervention program with risk of diabetes: A population-based matched cohort study

In this population-based study, Ernst Bergman and colleagues found that older adults who participated in a health assessment followed by a personalized counselling session were less likely to develop ...

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We publish impactful research that transforms global healthcare, prioritizing studies addressing critical health challenges that bridge scientific rigor with real-world impact, connecting researchers, clinicians, and policymakers to advance global health. 🔗 plos.io/4xC4UGk

Dan Routledge @droutledge.bsky.social · 4w ago

🚨 Conference attendance! Front Section Senior Editor Daniel Routledge @droutledge.bsky.social will be at the World Cancer Congress in Hong Kong this week! If you're also attending and want to discuss your research, the journal, open science, or more, feel free to reach out or say hi!🧪 #WCC2026

I first heard Gemma and Jodie present at the @crick.ac.uk Rare Diseases conference earlier this year, and it was a pleasure working with them on this Perspective article that emphasises a valuable message: that lived experience can and does meaningfully inform (rare disease) research🧪👏

PLOS Medicine@plosmedicine.org · 4w ago

In this Perspective, Gemma Whyatt & Jodi Whitehouse—two women living with the rare condition Congenital Melanocytic Naevus—outline why lived experience must shape #raredisease #research, & discuss how genuine patient-researcher partnership transforms science, care & identity🧪 #MedSky plos.io/4yaxMqe

Living with a rare disease: Why lived experience must shape research

In this Perspective, Gemma Whyatt and Jodi Whitehouse—two women living with the rare condition Congenital Melanocytic Naevus—outline why lived experience must shape rare disease research from the outs...

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