Il sistema immunitario “sente” fisicamente i microbi prima ancora di riconoscerli come tali Il “contatto fisico” dei microrganismi con le cellule immunitarie potrebbe essere la chiave di volta della risposta di un organismo nelle prime fasi di un’infezione. Grazie a questo meccanismo, il sistema…

Il sistema immunitario “sente” fisicamente i microbi prima ancora di riconoscerli come tali

Il “contatto fisico” dei microrganismi con le cellule immunitarie potrebbe essere la chiave di volta della risposta di un organismo nelle prime fasi di un’infezione. Grazie a questo meccanismo, il sistema immunitario può iniziare a reagire prima ancora di avere identificato il microrganismo attraverso i suoi segnali molecolari. A rivelarlo è lo studio “Microbial adhesion promotes Piezo1 activation to initiate innate immunity…

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Missed the full story? Here’s the 2-minute version. 👀 Our @natimmunol.nature.com RESEARCH BRIEFING is out: Dendritic cells sense #microbial adhesion to launch innate #immunity before canonical PRR recognition during #infection. www.nature.com/articles/s41... Full pdf: rdcu.be/ANm25wd4PkRa

Dendritic cells sense microbial adhesion to launch innate immunity - Nature Immunology

In a mouse skin infection model, microbial adhesion to CD11c+ myeloid cells activates PIEZO1 and an LTB4–IL-1α–CXCL1 cascade that recruits neutrophils before Toll-like receptor signaling becomes domin...

nature.com

In a mouse skin infection model, microbial adhesion to CD11c+ myeloid cells activates PIEZO1 and an LTB4–IL-1α–CXCL1 cascade that recruits neutrophils before Toll-like receptor signaling becomes dominant www.nature.com/articles/s41... www.nature.com/articles/s41... @natimmunol.nature.com

What if PRRs are not the first to sense #infection? 🚨Our new paper out in #NatureImmunology! @natimmunol.nature.com Microbial adhesion acts an unrecognized danger signal, activating #Piezo1 → LTB4 and triggering #PRR independent early #neutrophil recruitment. 🔗 www.nature.com/articles/s41...

Microbial adhesion promotes Piezo1 activation to initiate innate immunity - Nature Immunology

Granucci and colleagues identify microbial adhesion to myeloid cells as a critical initiating event that precedes engagement of pattern recognition receptors.

nature.com

The @febsletters.bsky.social Special Issue on dendritic cell biology is now online, offering a timely overview of recent progress in the field. It was a pleasure to be involved as a guest editor with Laura Marongiu & @fandreata.bsky.social

FEBS Letters@febsletters.bsky.social · last yr.

Our special issue on dendritic cell biology in health and disease is online now! Featuring 7 free Review articles on the role of dendritic cells in metabolism, cancer, and immunity, and more. Read the issue for free here ➡️ tinyurl.com/2zw4znee #dendriticcells #immunology @fandreata.bsky.social

✨ That’s a wrap on The Power of Multiplexed Imaging! A full week of hands-on sessions, inspiring lectures, a great seminar, and data analysis! Huge thanks to all participants for your energy. Can’t wait for the next edition — stay tuned! 🔬🌈 #MultiplexImaging #SpatialBiology

We had a great time at #SIICA2025 in beautiful Perugia! 🌿 It was a pleasure to share our research, connect with the community, and be inspired by so much great science. Special shoutout to our @roccagiuseppe.bsky.social for winning the Best Poster Award – well deserved! 🏆🎉 #Immunology

🚀 Registrations are OPEN! Join the 2nd edition of The Power of Multiplexed Imaging — a deep dive into spatial biology. 🔬 Inspiring talks, hands-on training, cutting-edge tech! Secure your spot 👉 academy.unimib.it/power-advanc... #MultiplexedImaging #SpatialBiology #ImagingCourse

✨ Reminiscing about last year’s multiplexed imaging course—such a fantastic experience! 🤩 We were thrilled to have @colinchulab.bsky.social, along with all the students & guests! Truly inspiring days of learning. Big things coming—stay tuned! 👀🚀🔬 #SpatialBiology #MultiplexImaging