Rare genetic variants in FNIP1 linked to favourable metabolic profile & 60% lower risk of cardiometabolic disease. Silencing FNIP1 pathway in mice induces fat breakdown and reproduces these metabolic benefits @nature.com www.nature.com/articles/d41... www.nature.com/articles/s41...

Metabolically activated compounds can redirect E3 ligase function, thereby expanding the scope of targeted protein degradation and chemically induced proximity @nature.com @danafarber.bsky.social @hojongyoon.bsky.social www.nature.com/articles/s41...

Programming a unique mode of immunogenic membranolytic cell death in tumor cells through spatiotemporal regulation of membrane-rupture using a synthetic pH-responsive membranolytic peptide @nature.com www.nature.com/articles/s41...

Virus reactivation in acute and long COVID-19 @nature.com @utaustin.bsky.social @dellmedschool.bsky.social @colemag.bsky.social www.nature.com/articles/s41...

Virtual Tissues foundation model resolves spatial proteomics across scales @nature.com @bunnech.bsky.social @wencksternjo.bsky.social @eeshaanjain.bsky.social www.nature.com/articles/s41...

Reshaping cortical circuits through stimulation is an emerging therapy for restoring cognitive function. Here find that stimulation strengthens cell assemblies, which is linked to cell-type-specific gene regulation @nature.com @konopkalab.bsky.social www.nature.com/articles/s41...

New Approach Opens Rare Immune Cells to Genetic Risk Research. Congratulations to the team! Learn more: scienceblog.cincinnatichildrens.org/new-approach...

Waggoner Lab@labwaggoner.bsky.social · yesterday

Excited this multi-year collaboration is in print @NatureGenet with @mspivakov.bsky.social @MalyValerie @HelenR_J Low-input Capture Hi-C reveals promoter-anchored chromosomal interactions in human ILC3 prioritzing CLN3 & other genes as potential ILC3-specific mediators of genetic risk for #IBD

Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity @nature.com @harvardmed.bsky.social www.nature.com/articles/s41...

Next-generation patient-derived models for diverse cancers @nature.com @broadinstitute.org @boehmjesse.bsky.social @sangerinstitute.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41... www.nature.com/articles/s41...

Activation of sphingosine-1-phosphate receptor 1 (S1PR1) G protein-coupled restores astrocyte primary cilia length, corrects molecular alterations and improved stress-related behaviours @nature.com www.nature.com/articles/s41...

ZFP36L2-deficient colorectal cancers cannot re-enter the LGR5+ state during metastatic outgrowth, promoting non-canonical lineage plasticity, which is associated with poor clinical outcomes www.nature.com/articles/s41... @nature.com @karunamdphd.bsky.social @mskcancercenter.bsky.social

An expanded codebook of human transcription factor DNA-binding specificity @nature.com @bartdeplancke.bsky.social @halfacrocodile.bsky.social @arttujolma.bsky.social @vorontsovie.bsky.social @downbythebayes.bsky.social @uoftpress.bsky.social #Hughes www.nature.com/articles/s41...

academic.oup.com/jimmunol/art...

NGL, never in a million years did I think LSD derivates would be fighting cancer but here we are. Haven’t read the article yet, but hoping the psychedelics at therapeutic doses help fight cancer a bit too!

Waggoner Lab@labwaggoner.bsky.social · 24h ago

By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinical models of colorectal cancer @cellcellpress.bsky.social www.cell.com/cell/fulltex...

CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity @cp-immunity.bsky.social @mariakoufaki.bsky.social @santiagozelenay.bsky.social www.cell.com/immunity/ful...

Establishment of germline-encoded antibodies during primary dengue infection @cellreports.bsky.social www.cell.com/cell-reports...

CD163+ red pulp macrophages interact with marginal metallophilic macrophages during blood-stage malaria to maintain splenic architecture www.cell.com/immunity/ful... @cp-immunity.bsky.social

By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinical models of colorectal cancer @cellcellpress.bsky.social www.cell.com/cell/fulltex...

TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo @jci.org @mayocliniccancer.bsky.social jci.org/articles/vie...

Review @jci.org Protein neddylation as a therapeutic target: challenges and opportunities jci.org/articles/vie...

Review @jci.org @mskcancercenter.bsky.social The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential jci.org/articles/vie...

IFNG-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease @insight.jci.org insight.jci.org/articles/vie...

CXCR4 coordinates adhesion, migration, and development of human NK cells @insight.jci.org @columbiauniversity.bsky.social insight.jci.org/articles/vie...

SorLA is a key regulator of B cell receptor trafficking, which binds immunoglobulin and controls endosomal sorting @jem.org @qubelfastofficial.bsky.social rupress.org/jem/article/...

New research published today in Nature Genetics uses a technique called mini-Capture Hi-C to map 3D DNA folding in rare ILC3 immune cells, linking 100+ genes to immune disease risk in this cell type 🧬

Mapping the 3D genome in rare immune cells reveals new genes linked with autoimmune disease risk

Researchers from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London, in collaboration with centres in Europe and the USA, have uncovered new genes linked to autoimmune conditions...

lms.mrc.ac.uk

Excited this multi-year collaboration is in print @NatureGenet with @mspivakov.bsky.social @MalyValerie @HelenR_J Low-input Capture Hi-C reveals promoter-anchored chromosomal interactions in human ILC3 prioritzing CLN3 & other genes as potential ILC3-specific mediators of genetic risk for #IBD

Mikhail Spivakov@mspivakov.bsky.social · yesterday

Very happy to see this story finally out (link in comments)! We used low-input Capture Hi-C to profile promoter-anchored chromosomal interactions in Type 3 innate lymphoid cells (ILC3s) - rare tissue-resident lymphocytes that lack antigen receptors and regulate barrier immunity.

How Respiratory Virus Symptoms Vary in Children scienceblog.cincinnatichildrens.org/how-respirat... publications.aap.org/pediatrics/a... @cincyresearch.bsky.social

Sad to hear of the passing of my former colleague! Sue built an incredible resource that was instrumental in many breakthroughs in JIA and pediatric rheumatology In Memoriam: Susan Thompson, PhD, 1958 – 2026 scienceblog.cincinnatichildrens.org/in-memoriam-... @cincyresearch.bsky.social

In Memoriam: Susan Thompson, PhD, 1958 – 2026 - Research Horizons

Learn about our Rheumatology division's first female faculty, whose research in juvenile arthritis helped shaped pediatric autoimmune research worldwide.

scienceblog.cincinnatichildrens.org

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective journals.sagepub.com/doi/10.1177/...

Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis @nature.com www.nature.com/articles/s41...