The first two successful PCRs as a fresh postdoc in the Materials Synthetic Biology group, led by Prof. Wilfried Weber. @matsynbio.bsky.social @leibnizinm.bsky.social Not a bad start to this exciting opportunity 🧬 🧫. Stay tuned for more!
Materials Synthetic Biology Group
@matsynbio.bsky.social
Creative synthetic biology, engineered living materials, and optogenetics research group of Prof. Wilfried Weber. Account run by Lab members. Website: https://www.leibniz-inm.de/en/research/scientific-units/materials-synthetic-biology/
Join our team: PhD opportunity in living therapeutic materials Our group is looking for an enthusiastic PhD to work on the development of safety-by-design strategies for living therapeutic materials. Apply by July 31st, 2025 : leibniz-inm.softgarden.io/job/57247378... @leibnizinm.bsky.social
Congrats to @wilfriedweber.bsky.social, Prof. Martin Ostermann & Dr. Martin Weber (@unistuttgart.bsky.social) for their VolkswagenStiftung project, ADMIRATION! They'll be creating biodegradable, bio-inspired building materials with fungi - www.f01.uni-stuttgart.de/fakultaet/ak...
VolkswagenStiftung fördert Forschung zu nachhaltigem Baustoff auf Pilzbasis | News | 02.04.2025 | Fakultät 1 Architektur und Stadtplanung | Universität Stuttgart
Projekt zu biologisch abbaubarem Baumaterial erhält Förderzusage über 1,4 Millionen Euro.
f01.uni-stuttgart.de
The @leibniz-gemeinschaft.de turns 30 this year! To celebrate, we are challenging ourselves to explain our research in a series of 30s clips. Here's the research of our Bioprogrammable Materials group, explained by @shrikrishnans.bsky.social youtube.com/shorts/P1CeT... #science
30s of science for 30 years of Leibniz
YouTube video by INM - Leibniz-Institut für Neue Materialien
youtube.com
Feel free to also follow the @loopoffun.bsky.social account to stay up to date with our LoopOfFun project! loop-of-fun.eu
Loop Of Fun | About
LoopOfFun is a platform for the rapid development of industry-scale, one-step, simple casting-based manufacturing processes for materials based on renewable and locally sourced raw materials.
loop-of-fun.eu
LoopOfFun@loopoffun.bsky.social · last yr.Great insights into the EIC ELMs Portfolio! LoopOfFun is excited to see the progress made in 2024 and looking forward to more collaboration and achievements within the Portfolio in 2025. Thank you, @bgerratana.bsky.social and SYMMONS Orsolya for all your supports! #EUeic #EICPathfinder #ELMs
As an introductory post, check out our latest paper in which we engineer a phase-separated synthetic organelle that translates metabolic signals into gene transcription regulation! pubs.acs.org/doi/full/10....
Metabolite-Responsive Control of Transcription by Phase Separation-Based Synthetic Organelles
Living natural materials have remarkable sensing abilities that translate external cues into functional changes of the material. The reconstruction of such sensing materials in bottom-up synthetic biology provides the opportunity to develop synthetic materials with life-like sensing and adaptation ability. Key to such functions are material modules that translate specific input signals into a biomolecular response. Here, we engineer a synthetic organelle based on liquid–liquid phase separation that translates a metabolic signal into the regulation of gene transcription. To this aim, we engineer the pyruvate-dependent repressor PdhR to undergo liquid–liquid phase separation in vitro by fusion to intrinsically disordered regions. We demonstrate that the resulting coacervates bind DNA harboring PdhR-responsive operator sites in a pyruvate dose-dependent and reversible manner. We observed that the activity of transcription units on the DNA was strongly attenuated following recruitment to the coacervates. However, the addition of pyruvate resulted in a reversible and dose-dependent reconstitution of transcriptional activity. The coacervate-based synthetic organelles linking metabolic cues to transcriptional signals represent a materials approach to confer stimulus responsiveness to minimal bottom-up synthetic biological systems and open opportunities in materials for sensor applications.
pubs.acs.org
Hi Bluesky! 👋 Here it is the Materials Synthetic Biology group at the @leibnizinm.bsky.social. Looking forward to connecting with the Synthetic Biology and Engineered Living Materials community!