New preprint on @medrxivpreprint.bsky.social from our 6-week RCT comparing two fermentable fibres with a non-fermentable control. We asked: • whether fibre effects depend on microbial fermentation • and whether microbiome differences explain variable responses 🔗 www.medrxiv.org/content/10.1...

Mechanistic insights into microbiome-dependent and personalized responses to dietary fibre in a randomized controlled trial

Dietary fiber supplementation can reduce cardiometabolic risk, but its effective use is limited by incomplete understanding of fibre-microbiome interactions and highly individualized responses. We tes...

medrxiv.org

Multicenter RCT in @lancetgastrohep.bsky.social: FMT (with live microbes) prevents recurrent C. diff far better than fecal filtrates. Thanks to Dina Kao (@ualberta.bsky.social) & @tsbschm.bsky.social from @apcmicrobiomeirel.bsky.social), and whole team. 🔗 authors.elsevier.com/c/1lphg8nByr...

Sebastian Schmidt@tsbschm.bsky.social · last yr.

Fecal filtrate is less effective than donor stool (FMT) for the treatment of C. difficile recurrence. Now shown in a multicentre trial, out today in @lancetgastrohep.bsky.social . Congratulations to Dina Kao @ualberta.bsky.social & team! Gift link: authors.elsevier.com/c/1lphg8nByr...

How has obesity treatment evolved, and where is it heading? Our new review in Obesity explores: ✔ The central role of nutrition ✔ Precision medicine & microbiome strategies ✔ Integration with emerging therapies Read here onlinelibrary.wiley.com/doi/full/10.... #Obesity #Nutrition #PrecisionMedicine

Evolution of multidisciplinary obesity treatments: past, present, and future role of nutrition

Obesity is a complex chronic disease requiring lifelong comprehensive treatment. In addition to lifestyle counseling that improves nutrition and physical activity, a promising new generation of obesi...

onlinelibrary.wiley.com

I joined Dr. Karan Rajan to talk about the science of the gut microbiome, how it’s changed through industrialisation, how we can restore it, and the NiMe diet. Grateful, and humbled, to discuss the #microbiome on a channel with 2M followers. 🎥 Watch here: www.youtube.com/watch?v=sb4d...

The NiMe Diet - Eat Like Our Ancestors For Better Gut Health

YouTube video by Dr Karan

youtube.com

Great podcast with Anissa Armet PhD RD on our recent @cellpress.bsky.social about the 'Non-industrialized Microbiome Restore (NiMe) Diet'. Covers a lot of the science, but also how Anissa's personal journey with IBD inspired both the research and the diet itself.

The International Scientific Assoc for Probiotics & Prebiotics@isappscience.bsky.social · 2y ago

Have you seen the hot-off-the-press "NiMe Diet" paper? Dr. Anissa Armet PhD RD explains the study in this edition of the podcast. (Plus, see the show notes for the NiMe Diet cookbook with the study's high-fiber recipes!) isappscience.org/episode-55-h...

Grateful to @natrevgastrohep.nature.com and Jordan Hindson for highlighting our recent @cellpress.bsky.social study on #microbiome restoration. Great to see our work featured in the Research Highlights section. 📄 Read the original paper: www.cell.com/cell/fulltex... #MicrobiomeResearch #GutHealth

Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation

Is it possible to restore the human gut microbiome in industrialized settings and reintroduce microbial species that have been lost? In healthy adults, Li et al. found that consuming a diet mimicking ...

cell.com

Nature Reviews Gastroenterology & Hepatology@natrevgastrohep.nature.com · 2y ago

ICYMI: New online! Diet-driven microbiome restoration associated with cardiometabolic benefits

It is hard to determine habitat adaptations in host-associated bacteria, e.g. because strains might be allochthonous or mislabeled. Here we present aurora, a gwas tool that identifies autochthonous strains and the genes associated with their habitats. doi.org/10.1186/s130...

aurora: a machine learning gwas tool for analyzing microbial habitat adaptation - Genome Biology

A primary goal of microbial genome-wide association studies is identifying genomic variants associated with a particular habitat. Existing tools fail to identify known causal variants if the analyzed ...

doi.org

I have been teaching classes on the gut #microbiome for almost 20 years and always struggled to have a good book to recommend. Finally there is one. Fergus Shanahan's "Fast Facts: The Gut Microbiome" provides expert insight, is brilliant, and it is free. doi.org/10.1159/isbn...

Fast Facts: The Gut Microbiome

‘Fast Facts: The Gut Microbiome’, though pithy and concise, is amazingly comprehensive and takes the reader through all major aspects of the human gut micr

doi.org

Eat to support your #microbiome. Anissa Armet and I are thrilled to announce our FREE 'science cookbook' on The NiMe Diet, bit.ly/41BV0HW, covering the story behind our research published in @cp-cell.bsky.social. If around Cork, register freely for an evening with the Creators on March 10th.

The NiMe Diet: Scientific Principles and... | ERA

Industrialized diets – high in processed foods and low in fibre – disrupt the gut microbiome and predispose us to chronic diseases, such...

bit.ly

Very much to our surprise, a strain of Limosilactobacillus reuteri drives severe pathology in a mouse model of multiple sclerosis. Pathology was driven by a secondary metabolite that hyperactivates the AhR receptor. See our publication in Cell Reports. www.sciencedirect.com/science/arti...

A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis

Limosilactobacillus reuteri is an immunomodulatory bacterium enriched in non-industrialized microbiomes, making it a therapeutic candidate for chronic…

sciencedirect.com

A new study led by Prof Jens Walter of @apcmicrobiomeirel.bsky.social reveals that a newly developed diet, inspired by the eating habits of non-industrialized societies, can significantly lower the risk of several chronic diseases. Read more here: www.researchireland.ie/news/non-ind...

Thank you to @naturerevmicro.bsky.social and Agustina Taglialegna for highlighting our work on microbiome restoration and the NiMe diet. Really nice summary.

Nature Reviews Microbiology@natrevmicro.nature.com · 2y ago

New online! A gut microbiome-restoring diet

Really nice to see my alma mater, @unihohenheim.bsky.social, post about our recent study in @cellpress.bsky.social. I spent most of my student years there (they have a historic park and a castle). Big thanks also to Stephan Bischoff and Dr. Benjamin Seethaler for another great collaboration.

Universität Hohenheim@unihohenheim.bsky.social · 2y ago

Ursprüngliche, nicht-industrialisierte #Ernährung senkt Risikofaktoren für #HerzKreislaufErkrankungen und #Diabetes, so eine Studie mit Beteiligung der #UniHohenheim: Restore-Diät senkt Gewicht, Cholesterin, Blutzucker und Entzündungswerte. Publikation in #Cell Pressemitteilung: sohub.io/mlia

Thank you @erictopol.bsky.social for highlighting our work. For those interested cooking some yummy healthy dishes that feed the #microbiome, all the recipes that were used in this human intervention trial are freely available on our instagram page. www.instagram.com/nimediet/

Eric Topol@erictopol.bsky.social · 2y ago

The impact of a non-industrialized ("Restore") diet plus a key microbe on improving cardiometaboiic health markers and reducing body-wide inflammation, from a randomized trial www.cell.com/cell/fulltex... @cellpress.bsky.social open-access

#weekendreading🔬 Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation @cellpress.bsky.social #microsky #microbiome #diet www.cell.com/cell/fulltex...

Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation

Is it possible to restore the human gut microbiome in industrialized settings and reintroduce microbial species that have been lost? In healthy adults, Li et al. found that consuming a diet mimicking ...

cell.com

Today we report a new compendium of human gut microbiomes with >168,000 samples By analyzing this massive dataset, we discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria Now out in Cell: www.cell.com/cell/fulltex...

Integration of 168,000 samples reveals global patterns of the human gut microbiome

The Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us...

cell.com

Our study @cellpress.bsky.social finds healthy Canadians that consume a non-industrialized-type #diet can modulate their #microbiome, boost beneficial metabolites and improve their health. In just 3 weeks: LDL cholesterol ↓17% fasting glucose ↓6% CRP ↓ 14% www.cell.com/cell/fulltex...

Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation

Is it possible to restore the human gut microbiome in industrialized settings and reintroduce microbial species that have been lost? In healthy adults, Li et al. found that consuming a diet mimicking ...

cell.com