Shouldn't last Monday's article from FDA staff have had a notice that “U.S. Government-authored contributions are in the public domain in the U.S.” rather than a copyright? It's not great when regulators speak via privately owned, paywalled channels.
The FDA Psychedelic Hearing is next week… here is everything you need to know. Event takes place virtually or in person on September 14, 11:30-4:30pm ET.
Mike Davis has been announced as head of FDA's CDER. He is a well-regarded FDA veteran who was CMO at the nonprofit psychedelic company Usona for about 3 years. www.hhs.gov/press-room/h...
HHS Announces Key Leadership Selections at FDA to Promote Innovation, Reform, and National Health Priorities
The U.S. Department of Health and Human Services today announced the selection of four senior leaders at the U.S. Food and Drug Administration.
hhs.gov
www.health.govt.nz/news/two-psy...
Two psychiatrists granted approval to prescribe medicinal MDMA for PTSD
Medsafe has approved two New Zealand psychiatrists to prescribe pharmaceutical-grade MDMA as part of a treatment programme for eligible adults with post-traumatic stress disorder (PTSD).
health.govt.nz
This is a genuinely exciting (mouse) result that may address a big unmet need and seemingly works with non psychedelic 2A agonists (tabernanthalog worked). www.science.org/doi/10.1126/...
Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment. In this ...
science.org
Cool work. Sounds to me like much of the novelty is in tracking the neural mechanisms. There was a lot of cool 50s era behaviorist research developing similar assignments. A few examples follow...
The Transmitter @thetransmitter.bsky.social · 4w ago“All men by nature desire to know” is the first line of Aristotle’s seminal work “Metaphysics.” New findings show that this statement extends across the animal kingdom to mice, too. #neuroskyence By @sarahthau.bsky.social www.thetransmitter.org/behavior/wou...
Arnold et al. find that RCTs investigating neuropathic pain often contain psychiatric-related exclusion criteria, potentially reducing the generalizability to a substantial population subset that experiences comorbid psychiatric disorders #PAIN bit.ly/4coVqGs
The most significant extension to the protocol since launch—atproto spaces—is now officially alpha software you can start testing with. Here's more about the goals and how to start testing. atproto.com/blog/atproto...
The Atproto Spaces Alpha is Live
Atproto Spaces, formerly known as “the permissioned data protocol,” is a new extension to atproto that enables non-public data. The alpha is now officially open. Here’s how to develop with it and what to expect as we work towards the full release.
atproto.com
www.biorxiv.org/content/10.6...
Tuning in together: LSD enhances inter-brain synchrony and felt connectedness in romantic couples
Social connection is fundamental to human wellbeing. Serotonergic psychedelics such as lysergic acid diethylamide (LSD) acutely heighten subjective connectedness, yet their effects on real-time social...
biorxiv.org
My hypothesis is that these findings reflect more of a threshold phenomenon in which you need to get a certain number of serotonin receptors activated and beyond that there’s no additional benefit.
Bita Moghaddam@bita137.bsky.social · last mo.Real data from real people treated with psilocybin in Oregon and Colorado hot takes: lack of a dose effect AND comparable benefits for depression and anxiety improvement in people taking SSRIs @zenbrainest.bsky.social 5HT2A occupancy matters less than context? www.medrxiv.org/content/10.6...
If you would like to teach theoretical modeling skills to your psychology or cognitive science students, or would like to learn these skills yourself, check out our open online textbook: computationalcognitivescience.github.io/lovelace/
This is an insightful conversation decodingbio.substack.com/p/a-conversa...
A Conversation with Jack Scannell: The Intractable ‘Sociotechnical’ Problems of Drug Discovery and Development, Genetic Triumphalism and Predictive Validity
Jack is one of the sharpest thinkers on the pharmaceutical industry, with a talent for coining terms that then propagate among industry insiders and into wider tech circles.
decodingbio.substack.com
Lilly is buying AtaiBeckley in the largest psychedelics deal yet. I wrote a few thoughts on Linkedin on what the deal actually commits it to, what it leaves out, and what the rest of the year will tell us. www.linkedin.com/pulse/what-l...
This project of early-career biologists curating and commenting on preprints looks cool. prelights.biologists.com/about-us/
About us - preLights
Welcome to preLights, the preprint highlights service run by the biological community and supported by The Company of Biologists. What is preLights? As the number of preprints grows, it will become in...
prelights.biologists.com
MadScientist@mads100tist.bsky.social · 3mo agoDon't use slop. Someone's trying to make money out of you and your colleagues and your friends. Do yourself a favor and read 100% human-crated content in @prelights.bsky.social Upload preprints. Read preprints. Cite preprints. Fuck AI 🧪
Looks like groups outside the scientific community are commenting in higher numbers Day 18: 35,323 total comments, 17,458 mention science, 19,135 mention research
anil oza@aniloza.bsky.social · 3mo agoBeen a while since I checked Day 14 (I'm counting business days): 25328 total comments, 12324 mention science, 13832 mention research
Really excited about this work with the awesome Will de Cothi & @shipleysj.bsky.social, out in Nature Reviews Neuroscience. We propose acetylcholine is an analogue of dopamine — tracking not reward prediction errors but state-transition prediction errors. https://doi.org/10.1038/s41583-026-01058-w
Instead of giving clicks to the #1 Newspaper that supported the invasion of Iraq, maybe look at this article about how dangerous American pickup trucks are by my lovely co-host, who never once laundered the American invasion of Iraq
victoria scott@victoriascott.bsky.social · 3mo agoIf you’d like the gist of this article a small-time blogger covered it two years ago www.motor1.com/features/713...
Important preprint on the risks of ibogaine in clinics (19,071 patients, 11 clinics): all 6 deaths within 72h were in opioid-detox patients, 0 among 8,689 non-SUD patients, supporting the idea that risk clusters in opioid detox not the TBI/PTSD indications. www.researchsquare.com/article/rs-9...
Indication-stratified mortality risk of ibogaine treatment under contemporary safety protocols: a multisite analysis of 19,071 patients and updated systematic review of fatalities
Ibogaine has shown early therapeutic promise for substance use disorders (SUD) and post-traumatic stress disorder in veterans, but concerns about treatment-associated cardiac arrhythmia and death have...
researchsquare.com
If you developed a drug that successfully slowed human aging, how would you actually get it approved by the FDA? Here are my notes on what the FDA signaled at the recent Reagan-Udall Foundation meeting. www.linkedin.com/pulse/roadma...
Science mystery! Nearly everyone, everywhere, veers left when walking. Why??? www.nytimes.com/2026/06/10/s... @nytimes.com
Nearly Everyone, Everywhere, Veers Left When Walking
nytimes.com
Steve Cohen (TN-9) yesterday introduced the Controlled Substances Act (CSA) Clarification in Sciences Act to update the 1970 CSA, which is greatly needed. Text is not yet available but will be here www.congress.gov/bill/119th-c...
congress.gov
I wrote about the new rule proposing political oversight of every form of federal grant-making and what it means, legally, for OMB to do this. Wild it's gotten nearly 5k comments in < a week. Thanks to Carrie Wolinetz, @cdelawalla.bsky.social for their insights cen.acs.org/policy/resea...
White House move to step up political role in US research sparks alarm
An Office of Management and Budget proposal would insert political oversight into federal grant decisions, downgrade peer review, and expose all grants to termination without cause
cen.acs.org
OMB has proposed a sweeping overhaul of how federal research grants are awarded, terminated, and funded. I just posted my planned comments on LinkedIn in the hope it will make it easier for others to submit their own comments. www.linkedin.com/pulse/ombs-p...
Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)
Science Needs 3rd Spaces We envision scientific third spaces as “collaborative hubs where researchers, artists, engineers, and practitioners co-develop methods, share resources, and pursue projects driven by curiosity". authors.elsevier.com/sd/article/S...
Going through an issue of the TLS from last December, I find a philosophy pun courtesy of Nigel Warburton that surely deserves wider currantsy.
