They said flies could develop without centrosomes. The embryos may beg to differ. Jeny Jose highlights a recent #preprint from Beatriz González & colleagues @araujolabub.bsky.social – post includes an insightful authors’ response #preLight ⬇️ prelights.biologists.com/highlights/c...

Centrosome Loss Alters Axonal and Muscle Development - preLights

They said flies could develop without centrosomes. The embryos may beg to differ.

prelights.biologists.com

The title really intrigued me, but I couldn't have imagined how much I would love this paper! Actually, I was so excited by the findings that I wrote a @prelights.bsky.social😄 If you haven't read it yet, go dive into this amazing paper lead by @noelponte.bsky.social 🤩 www.biorxiv.org/content/10.6...

Brassinosteroid receptors reveal conserved features of exon-embedded gene regulation

Precise quantitative and spatial control of plant gene expression is typically attributed to cis-regulatory elements in promoters and other non-coding sequences. The extent to which exon-encoded regul...

biorxiv.org

preLights@prelights.bsky.social · 6d ago

Hide and seek: exonic sequences harbor cis regulatory elements and regulate spatial expression of brassinosteroids receptors. #PlantBiology @karimaelm.bsky.social covers a recent #preprint by Raúl Denia-Mondéjar et al. @noelponte.bsky.social #preLight ⬇️ prelights.biologists.com/highlights/b...

Cellquant: a vibecoder’s guide to image analysis Abani Neferkara & colleagues #PincusLab #UChicago assemble and deploy an LLM–assisted, Python–based script for biological image segmentation. #preprint #preLight by Theodora Stougiannou ⬇️ prelights.biologists.com/highlights/c...

It's incredible how expansion microscopy has advanced in the past few years. Check out @lydia-kisley.bsky.social ’s lab latest preprint showing their new device for this field! @prelights.bsky.social prelights.biologists.com/highlights/t...

The Tensile Expansion Microscopy (TExM) cell stretcher: an iris expansion device integrated with automated real-time autofocus and tracking to super-resolve cells - preLights

A new stretch-o-matic? Meet the tensile expansion microscopy device !

prelights.biologists.com

Combining HiExM with single-organelle segmentation & machine learning reveals cellular patterns beyond the average. #BoyerLab @dina-kabbara.bsky.social: "What stands out to me most is how often a bulk average concealed meaningful differences..." #preLight⬇️ prelights.biologists.com/highlights/h...

HiExM Enables Scalable Mapping of Organelle Morphology and Spatial Heterogeneity - preLights

HiExM meets AI, revealing cellular patterns beyond the average.

prelights.biologists.com

This has been a very fun initiative. To many more!

preLights@prelights.bsky.social · last wk.

What #preprints have the @dev-journal.bsky.social Preprint Editors been reading? Since June, they've been showcasing standout #DevBio preprints through the ‘In preprints’ series. We've collected the ones published (so far!) in one #preList ⬇️ prelights.biologists.com/prelists/in-...

Want to make your research presentations more engaging, identify the stories within your science and create compelling visual summaries of your work? Join us on 10 November 2026 from 13:00-17:00 GMT for a free half-day workshop: prelights.biologists.com/news/registe...

Hide and seek: exonic sequences harbor cis regulatory elements and regulate spatial expression of brassinosteroids receptors. #PlantBiology @karimaelm.bsky.social covers a recent #preprint by Raúl Denia-Mondéjar et al. @noelponte.bsky.social #preLight ⬇️ prelights.biologists.com/highlights/b...

Brassinosteroid receptors reveal conserved features of exon-embedded gene regulation - preLights

Hide and seek: exonic sequences harbor cis regulatory elements and regulate spatial expression of brassinosteroids receptors.

prelights.biologists.com

Intrinsic3D, a new imaging approach that allows researchers to image entire cells + tissues in 3D at single-molecule resolution, making large-volume super-resolution imaging faster & easier. @kanishka03.bsky.social covers work #StJohnstonLab - #preLight ⬇️ prelights.biologists.com/highlights/f...

Fast single molecule localization microscopy in 3D - preLights

Intrinsic3D, a new imaging approach that allows researchers to image entire cells and tissues in 3D at single-molecule resolution, making large-volume super-resolution imaging faster and easier.

prelights.biologists.com

Jia Chen@chenjiajiachen.bsky.social · 2w ago

Fresh preprint from St Johnston lab in collaboration with Paluch lab. "Fast, 3D SMLM imaging modality, Intrinsic3D, which combines the speed and optical sectioning of oblique plane microscopy (OPM) with the nanometre resolution of SMLM using DNAPAINT". Amazing imaging, here is one of my favourite:

What #preprints have the @dev-journal.bsky.social Preprint Editors been reading? Since June, they've been showcasing standout #DevBio preprints through the ‘In preprints’ series. We've collected the ones published (so far!) in one #preList ⬇️ prelights.biologists.com/prelists/in-...

‘In preprints’ from Development 2026 - preLights

A list of the preprints featured in Development's 'In preprints' articles, as part of the new Preprint Editors initiative

prelights.biologists.com

A new plant-bacteria immunological connection in the first preprint of our group at @mpi-bio-fml.bsky.social @plantevolution.bsky.social! Straight from the top of Mt. Olympus ⛰️🦅 Led by Eirik @eiriklag.bsky.social, in collaboration with @geminiteamlab.bsky.social www.biorxiv.org/content/10.6...

In preprints – making blood stem cells: how close is close enough? Roshana Thambyrajah @roshanathambyrajah.bsky.social discusses 2 recent preprints by Cwycyshyn & co and Jain & co, asking a fundamental question: what exactly are engineered hematopoietic stem cells? doi.org/10.1242/dev....

In preprints – making blood stem cells: how close is close enough?

This article discusses version 5 of the preprinted work of Cwycyshyn et al. (2024 preprint) as well as preprinted work of Jain et al. (2026 preprint). As preprints, these works have not yet undergone…

doi.org

When a neuron’s waste is too big to carry home, microglia pinch it off from the outside – in a process called skoupocytosis, from the Greek for garbage. @chandrrrika.bsky.social covers a #preprint from Renee Pepper et al. @watanabelab.bsky.social #preLight⬇️ prelights.biologists.com/highlights/m...

Microglia extract neuronal proteolytic organelles via skoupocytosis - preLights

When a neuron’s waste is too big to carry home, microglia pinch it off from the outside – in a process called skoupocytosis, from the Greek for garbage.

prelights.biologists.com

Crouching AI, hidden connections Theodora Stougiannou covers work introducing an AI-based semantics workflow to facilitate data integration across heterogeneous databases. #preprint James McLaughlin et al. @helenparkinson.bsky.social #OpenScience #preLight⬇️ prelights.biologists.com/highlights/a...

AI semantics for biomedical data integration - preLights

Crouching AI, hidden connections; The preprint authors assemble and deploy an artificial intelligence (AI)-based semantics workflow to facilitate data integration across heterogeneous databases.

prelights.biologists.com

How do plants take shape? The latest preList by @ingridtsang.bsky.social bundles #preprints discussed at #SLS26 A list that features work on plant development, tissue mechanics, stomatal patterning, leaf shape & computational modelling #PlantScience #preList⬇️ prelights.biologists.com/prelists/sai...

Sainsbury Laboratory Symposium 2026 - preLights

The Sainsbury Laboratory Symposium 2026, Shaping Life: Mechanisms of Morphogenesis, brought together researchers exploring the cellular, genetic and mechanical processes that shape plant form. This preList highlights preprints that were discussed or mentioned at the meeting. If you notice any missing preprints, please contact us at preLights@biologists.com

prelights.biologists.com

🔬📝Here’s our latest #preprint list on FocalPlane. This week we focus on preprints that use microscopy to answer questions in biology. Let us know if you have any recommendations of preprints to add to this list or our future lists. focalplane.biologists.com/2026/10/05/m...

Microscopy preprints: applications in biology - FocalPlane

Microscopy preprints: applications in biology - News

focalplane.biologists.com

Did you ever wonder how the leopard got its spots? Or how the zebra got its stripes? Wonder no more! In this #Short, @benswedlund.bsky.social talks about his #preprint describing reaction-diffusion architecture for engineering self-organised patterns in mammalian cells. 🎙️⬇️ youtu.be/_HMbr4KE1PI?...

spotLights Ep 23: Benjamin on programming self-organising cell patterns #syntheticbiology #biology

YouTube video by The Company of Biologists

youtu.be

Did one gene family help plants colonise land? Zamar et al. @pierremarcdelaux.bsky.social show how a land-plant-specific enzyme family, p-GPATs, is involved in two different processes: cuticle formation & arbuscular mycorrhizal symbiosis #preLight by Naveen⬇️ prelights.biologists.com/highlights/a...

A single genetic innovation at the origin of plant terrestrialization - preLights

A land-plant-specific p-GPAT family links cuticle formation and arbuscular mycorrhizal symbiosis, suggesting that one biochemical innovation may have helped early plants adapt to life on land.

prelights.biologists.com

Two #preprints detail new & complementary ways to match mechanical readouts from tissues to OMICs. #preLight by @fadelvalle.bsky.social - includes a discussion with the author teams @lindithium.bsky.social @huanting-ong.bsky.social @jennyoung.bsky.social ⬇️ prelights.biologists.com/highlights/m...

MechanoMaST – a multimodal pipeline for spatially registering mechanical and transcriptomic tissue data; Paired-surface spatial mechanomics links tissue stiffness maps to spatial transcriptomics - pre...

Separated by only a few hours! These two novel preprints detail new and complementary ways to match mechanical readouts from tissues to OMICs

prelights.biologists.com

I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

Paid peer review is not science fiction! As part of @prelights.bsky.social, I was joined the #Fast&Fair initiative from @biologyopen.bsky.social. Fast&Fair compensates reviewers who submit a high-quality peer review in a timely manner, so authors get a first decision in seven working days (1/4).

Proud to present our latest work "Tracking human foragers and their prey reveals adaptive predator-prey dynamics", now hosted on BioRxiv! 🧵 doi.org/10.64898/202... @ralfkurvers.bsky.social @scioi.bsky.social @arc-mpib.bsky.social @alexschakowski.bsky.social @dominikdeffner.bsky.social

Watch the story of foregut folding unfold 👀 Ruoheng Li highlights recent work identifying and quantitatively describing the stereotypical sequence of foregut involution. #preprint @jennykre.bsky.social #McDoleLab #preLight + response from the authors ⬇️ prelights.biologists.com/highlights/c...

Choreographed morphogenetic events underlie early foregut development in the mouse embryo - preLights

Watch the story of foregut folding unfold

prelights.biologists.com

🧬 Preprint! 🧵 Our goal is to genetically manipulate every embryonic germ layer to enable high throughput in vivo studies. We previously showed mouse ectoderm can be targeted by amniotic injection, enabling cell-specific manipulation, lineage tracing, and knockouts. But how to reach mesoderm?

Excited to share our new preprint! 📜 Here, we used CALVADOS and ultra-CG models to show how the kinetochore establishes a robust attachment to the dynamic microtubule end. Spoiler: IDRs 🧵 1/n www.biorxiv.org/content/10.6...

DNA barcoding systems that uniquely label progenitors allow us to trace their fate. Marine Secchi highlights a #preprint presenting a novel method to analyse complex clonal patterns @sergeyisaev.bsky.social @alekerickson.bsky.social @adameykolab.bsky.social prelights.biologists.com/highlights/c...

Clonal embeddings allow exploratory analysis of lineage-resolved single-cell data - preLights

DNA barcoding systems that uniquely label progenitors allow us to trace their fate. This preprint presents a novel method to analyse complex clonal patterns.

prelights.biologists.com

🚨 New preprint from the lab! 🚨 Transcriptomic profiling identifies cellular and molecular transitions during Merkel cell regeneration www.biorxiv.org/content/10.6...

Transcriptomic profiling identifies cellular and molecular transitions during Merkel cell regeneration

Skin exhibits a remarkable capacity for regeneration, which requires the coordinated reconstitution of diverse cell types and structures. Merkel cells are mechanosensory cells that detect gentle touch...

biorxiv.org

Check out our new preprint: a very cool fluorescence tool developed by @samwalds.bsky.social www.biorxiv.org/content/10.6...

Intronised fluorophores improve reporter output and biosensor expression in plants

Genetically encoded biosensors are central to plant cell biology, but low reporter signal can limit their use. Here, we developed modular intronised fluorophores to improve reporter output in transien...

biorxiv.org

What molecular mechanisms underlie the needle-in-a-haystack search for homology required to fix a DNA break? In this preprint, we reveal multiple controls of homology search in cells: onset, coordination, reach and inactivation. www.biorxiv.org/content/10.6...

Paying peer reviewers: it's not Science Fiction As a postdoc involved in Fast & Fair peer review @biologyopen.bsky.social, @jontytownson.bsky.social reflects on what paid peer review could mean for the future of research publishing #NPAW2026 #preLight ⬇️ prelights.biologists.com/highlights/e...

Expanded implementation of Fast & Fair paid peer review reduces time to first decision without reducing review quality in a biology journal; Fast & Fair peer review: a pilot study demonstrating feasib...

Paying peer reviewers: It's not Science Fiction

prelights.biologists.com