Come work with us! For more information, and to apply, visit: careers.pageuppeople.com/513/cw/en/jo... Please contact Dr Liz Ryan (Liz.Ryan@monash.edu) with any questions or for additional information. Applications close on July 22, 2026. @austrim-cre.bsky.social

Is multiple imputation more powerful than complete case analysis in clinical trials? A systematic review by Thomas Sullivan found multiple imputation often led to noticeable changes in the effect estimate but did not demonstrate consistent precision advantages. #ClinicalTrials

Kylie Lange and colleagues outline a sample size calculator for clinical trials in which some participants are independent and others are clustered, such as multiple births. @klange-au.bsky.social @sahmri.bsky.social @austrim-cre.bsky.social

🚨New publication! The final piece of my PhD was to translate the earlier theoretical work into a free sample size calculator for designing partially clustered trials. Really happy to now see this out there to help researchers plan high quality trials. Paper is linked below ⬇️ Calculator is here:

AusTriM CRE@austrim-cre.bsky.social · 6mo ago

"An online sample size calculator for designing partially clustered trials" (@klange-au.bsky.social et al) has now been published in Clinical Trials! doi.org/10.1177/1740... This free and user-friendly online calculator makes it easier to ensure a trial is appropriately powered ✅

This week! Prof Ian Marschner from the NHMRC Clinical Trials Centre will be presenting the @vicbiostat.bsky.social seminar on Confidence distributions. All welcome online or in person. Friday 21 November 9:30am AEDT, Monash SPHPM. www.vicbiostat.org.au/event/confid...

Time for some updates! 🎓Celebrated the official end of my PhD journey with graduation from The University of Adelaide. PhDONE! 💼Now fully settled in as a postdoc in the Biostatistics Unit at @sahmri.bsky.social ⚕️Pleased to also be continuing my role supporting clinical research at UofA

I'm looking forward to going to Melbourne for this - it promises to be a great meeting!

AusTriM CRE@austrim-cre.bsky.social · 11mo ago

Join us at the 3rd biennial Australian Trials Methodology Conference as we explore "Better trials through better methods" Crown Promenade, Melbourne (+ online access options) 20/11/25 Early-bird registration ends 26/9 www.atmc25.com #ClinicalTrials #Biostatistics

📢 Australian Trials Methodology Conference 2025 🗓 20 Nov | 📍Melbourne & Online via Zoom Join leading speakers from academia, industry & healthcare. 🎟 Early-bird rates until 26 Sep! 🔗Register: atmc25.com #ClinicalTrials #TrialMethodology #Biostatistics @vicbiostat.bsky.social

📣New publication alert! The latest paper from my PhD is now online at Statistics in Medicine, presenting new sample size formulas for clinical trials that include partial clustering. Really happy to see this work out in the world! 🧵1/4 dx.doi.org/10.1002/sim....

Sample Size Calculations for Partially Clustered Trials

Partially clustered trials are defined as trials where some observations belong to a cluster and others are independent. For example, neonatal trials may include infants from a single, twin, or tripl...

dx.doi.org

I'm looking for a senior research fellow or research fellow to join my group (the Cluster Cluster!) at Monash University, to develop statistical methodology of adaptive longitudinal cluster randomised trials. Come join us for 3 years in marvellous Melbourne! careers.pageuppeople.com/513/cw/en/jo...

New #preprint with @nicolewhite.bsky.social and @tayacollyer.bsky.social. We examined if Australian ethics committees use qualified statistical expertise. Our results revealed a large variation in practice, with some committees using qualified statisticians […] (1 of 4) osf.io/preprints/os...

One of the motivating examples of partial clustering for my PhD research is the inclusion of infants from multiple births in neonatal trials. Kristy Robledo has just published a review of how multiple births are dealt with in these trials - and the news isn't great! 1/2 fn.bmj.com/content/earl...

We should do better in accounting for multiple births in neonatal randomised trials: a methodological systematic review

Objective To conduct a methodological systematic review of multicentre trials of premature infants to (1) determine if and how multiple births have been considered in the design, analysis and reportin...

fn.bmj.com

My PhD research is on statistical issues in partially clustered clinical trials - these are trials that involve both independent and clustered observations. Check out this paper for details on where they occur and how we should be describing them: journals.sagepub.com/doi/10.1177/... (1/3)

Partially clustered designs for clinical trials: Unifying existing designs using consistent terminology - Kylie M Lange, Jessica Kasza, Thomas R Sullivan, Lisa N Yelland, 2023

Introduction: Clinical trial designs based on the assumption of independent observations are well established. Clustered clinical trial designs, where all obser...

journals.sagepub.com