Tessera

Italian SPRING cohort of #SSc pts found only 5.3% (of 1689 pts) without the typical scleroderma pattern on nailfold change by NVC. They had milder dz, less vascular dz (pitting 33 vs 48%, telangiect 52 vs 74%, calcinosis 3.4 vs 12%) & higher DLCOs, p < 0.05 pmc.ncbi.nlm.nih.gov/articles/PMC...

Retrospective Medicare comparison 450 paired #PMR cohorts Rx w/ IL-6 inhib or csDMARDs. At 1 yr, IL-6i pts (vs csDMARD) had signif more GC D/C (adj HR 1.28) or minimal GC use (aHR 1.28). Hosp. infxn 2X higher in IL-6i (12.2 vs 5.7 per 100 PY) in year 1, but not year 2 rmdopen.bmj.com/content/12/3...

Prolonged targeted Rx in #SpA not assoc w/ increased cancer risk. French claims study 56,591 SpA pts- 1,224 CA. TNFi, IL17i, IL12/23i, IL23i, JAKi Exposure >6 vs ≤6 mos assoc w/ lower CA (HR 0.86); signif for Heme (HR 0.65), not solid CA (HR 0.92) acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

QD Clinic: A Watched Tophus Never Resolves Dr. Jack Cush discusses his plan to medically manage multiple large volume tophi and a patient who has recently started urate lowering therapy with febuxostat. buff.ly/uISN0Nw

Efgartigimod Efficacy in Idiopathic Inflammatory Myopathy Today Argenx announced the results of their Phase 3 "ALKIVIA" study; demonstrating efficacy and safety of subcutaneous efgartigimod for Idiopathic Inflammatory Myopathy (IIM, AKA inflammatory myositis). buff.ly/9NXBIlk

"Great teachers set it up, and great students find the aha." - Seth Godin seths.blog/2026/08/dont...

Don’t steal the revelation

Teaching and learning aren’t always aligned. Sometimes organized teaching is defensive. “Here, take all this down in your notes, it will be on the test.” This gives the teacher de…

seths.blog

In 2026 Abbvie granted 34 scholarships to students w/ Inflammatory Dz. In the last 10 yrs, theyve granted $6 million to >350 students in the US for higher education. These awards up to $20,000 per student renewable up to 4 yrs. www.abbvieimmunologyscholarship.com thedermdigest.com/abbvie-gives...

AbbVie Gives Back: 34 Students With Inflammatory Diseases Receive Scholarships in 2026 - The Dermatology Digest

Thirty-four students living with inflammatory conditions across dermatology, gastroenterology, and rheumatology received the 2026 AbbVie Immunology Scholarship.

thedermdigest.com

EU Finalizes Tavneos Withdrawal; European Commission officially revoked the marketing authorization for avacopan; regulators flagged the drug's pivotal trial data as "incorrect and misleading." EC issued its binding decision on August 4, 2026 www.americanpharmaceuticalreview.com/1315-News/62...

EU Finalizes Tavneos Withdrawal as European Commission Confirms Data Integrity Findings

The European Commission has officially revoked the marketing authorization for Tavneos (avacopan), finalizing a process that began with regulators flagging the drug's pivotal trial data as

americanpharmaceuticalreview.com

Doubting RS3PE (8.14.2026) Dr. Jack Cush reviews the news and journal articles this week where RheumNow featured info on cancer, deadly viruses, AI rules, poetry and good moons rising. buff.ly/QUjC18Q

Multiple chronic conditions (MCCs; AKA multimorbidity) is highly prevalent in AIRDs; complicates Rx & increases adverse outcomes & all-cause mortality. MMCs 86% in RA, 81.5% in SLE, w/ a notable patterns of cardiopulmonary and mental health disorders journals.sagepub.com/doi/full/10....

MCCs in adults with autoimmune and inflammatory rheumatic diseases: evidence to date and future directions - Namrata Singh, Jerry H. Gurwitz, Sarah B. Lieber, 2026

Multiple chronic conditions (MCCs), also known as multimorbidity, are highly prevalent in adults with autoimmune and inflammatory rheumatic diseases (AIIRDs) an...

journals.sagepub.com

2026 Medscape report on Nurse practitioners shows nearly half of NPs are burned out, and for 1 in 6, that exhaustion has curdled into something heavier: both burnout and depression. Worse, 63% of NPs don't believe relief is in sight

SLE & Dermatomyositis rashes maybe classically red or violaceous in Whites,but different in people of color, where erythema often appears brown/violaceous, Gottron papules can called dry skin, & delay dx, esp in anti-MDA5+ RP-ILD, where rash may be the only clue. www.amjmed.com/article/S000...

Review of CAR-T 29 trials in systemic sclerosis (SSc): 27/29 target CD19 (other CD20, BCMA), 20/29 autologous. Only 2 RCTs; 1 w/ RTX comparator. Most included CREST. Schetts largest series had 6 dcSSc w/ skin/lung improvements. Need fewer & larger multicenter RCTs www.jrheum.org/content/53/S...

Are We Putting the “Cart” Before the Horse in Systemic Sclerosis? A Review of the CAR-T Studies in Scleroderma

Objectives Chimeric antigen receptor T-cell (CAR-T) therapy is emerging as a novel approach for systemic sclerosis (SSc). We reviewed the current trial landscape—including study design, therapeutic…

jrheum.org

French study of 90 RA F pts w/ 100 pregnancies (steroids 46% & biologics 39% were used). Vs 359 controls, RA had signif. more preterm birth (PTB;OR 2.08) & small for gestat. age. SGA assoc w/ nulliparity (adj OR 4.38), PTB assoc w/ maternal age (aOR 1.14) & GC ≥10 mg/d (aOR 4.91) buff.ly/j6KSVu3~

https://buff.ly/j6KSVu3

buff.ly

FDA & Fresenius Kabi Issues Nationwide Recall of Tyenne® (tocilizumab biosimilar) Injection 400 mg/20 mL Vials Due to Presence of Glass Particles. Applies to NDC Number 65219-594-20, Lot Number 16UI07 , Expiration date: 08/2028 . FDA warns possible ISR or VTE. www.fda.gov/safety/recal...

Fresenius Kabi Issues Nationwide Recall of Tyenne® (tocilizumab-aazg) Injection 400 mg/20 mL Vials Due to Presence of Glass Particles

FOR IMMEDIATE RELEASE – August 10, 2026 – LAKE ZURICH, Ill.— Fresenius Kabi, an operating company of the Fresenius Group, is recalling one lot of Tyenne® (tocilizumab-aazg) Injection 400 mg/20 mL (20…

fda.gov

US TriNetX EHR study of of seropositive RA:  31,932 without ILD; 115 RA-ILD on antifibrotic Rx & 1885 RA-ILD not Rx w/ antifibrotics. MTX was used more in RA w/o ILD (52%) vs RA-ILD (12%) on antifibrotics. RA-ILD was assoc w/ heterogeneous antifibrotic use. www.sciencedirect.com/science/arti...

https://www.sciencedirect.com/science/article/abs/pii/S0954611126004270

sciencedirect.com

Dr. John Cush @rheumnow.bsky.social · 7d ago

3 SLE pts w/ Bx class III/IV LN had proteinuria flares (4.6–13.4 g/d) despite MMF & belimumab -->given voclosporin (+MMF) w/ rapid, sustained proteinuria reduced (≤0.7 g/day w/in 9–12 mos) & stable/improved eGFR, & GC tapering. Creat increases Rx w/ dose adjustments academic.oup.com/joneph/advan...

Voclosporin for the treatment of lupus nephritis flares in patients with inadequate response to mycophenolate mofetil and belimumab: a case series

Abstract. Lupus nephritis (LN) is a frequent and severe manifestation of systemic lupus erythematosus (SLE) associated with progression to kidney failure i

academic.oup.com

New, Advanced Therapies in Gout buff.ly/05OsQYw

Dr. John Cush @rheumnow.bsky.social · 7d ago

2026 BSR Pain Guideline: What Rheumatologists Need to Know The British Society for Rheumatology has issued its first guideline dedicated solely to pain in inflammatory arthritis (IA)—covering RA, PsA, axial SpA and JIA. buff.ly/w8bJc4g

Updated Guidance for AI Use in Medical Publications JAMA has updated its guidance for the acceptable use of AI in authoring a med publication. Despite growing use, disclosure rates remain very low. This update provides specifics on what is permitted/not permitted and disclosures. buff.ly/ESi6R0T

NHANES survey (2005-2018) studied arthritis in adults w/ depression (PHQ-9 ≥10), From 15157 depressed pts, RA most prevalent & increased 7.8 to 17.7%; OA same 11.7 to 10.7% & PsA declined 7.2 to 1.7%. Depression assoc w/ ^risk for RA (OR 1.40) & PsA (OR 1.44) journals.sagepub.com/doi/10.1177/...

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

2026 PGY1 match for non–US citizen international medical graduates (IMGs) has reached a 5-year low; US health care relies on non–US-born MDs. In US, there are 6300 Rheumatologists - 46.9% US born USMG; 5.4% US born IMG; 11.2% non-US born USMG; 36.5% non-US born IMG jamanetwork.com/journals/jam...

Non–US-Born Physicians in the US Internal Medicine Workforce

This study estimates the share of US-born and non–US-born US medical graduates (USMGs) and international medical graduates (IMGs) in the US internal medicine workforce, as well as the share of…

jamanetwork.com