Swedish study of 1097 #RA pts looked at modifiable healthy lifestyle habits (HLHs: EtOH use, smoking, physical activity). At Baseline, 56% had three HLHs , unchanged (58%) at Yr 3. Nonsmoking incr 77-83%, healthy alcohol from 85%-97%. but healthy PA decr 84-71%. academic.oup.com/rheumatology...

Patterns and changes in lifestyle habits of patients with rheumatoid arthritis during the first three years post-diagnosis

AbstractObjectives. This study aimed to in patients with RA (Rheumatoid Arthritis) describe patterns and changes in healthy lifestyle habits (HLHs’—alcohol

academic.oup.com

Leeds study of 44 patients idiopathic inflamm myopathy (IIM) pts Rx w/ rituximab showed a 70% response 4-6 mos post RTX. Responders had higher TIS (50·0 vs 17·5). Using highly sensitive flow cytometry, @ 2 wks responders had lower #s memory B cells & Plasmablasts. www.thelancet.com/journals/lan...

https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(26)00215-8/fulltext

thelancet.com

12 mos Danish study of 157 822 first-time semaglutide for obesity management (SOM) intiators. 77 483 discontinued treatment w/in 12 mos. (13% at 3 mo, 27% 6 mos, 39% @ 9 mos. Few changed to another GLP-1 med jamanetwork.com/journals/jam...

Swedish Registry of 4317 AAV pts showed GPA & MPA had signif incr risk CV dz (HR 2.04) & thromboembolism (HR 2.45); males incr MI risk (HR 2.25) & females incr ischemic stroke risk (HR 1.64). The highest CVD-TE risk occurred within 3 mos. of Dx (HR 7.69) academic.oup.com/rheumatology...

Cardiovascular and thromboembolic risk in anti-neutrophil cytoplasmic antibody-associated vasculitis: a nationwide matched cohort study by disease, sex, and familial risk

AbstractObjectives. To investigate influence of sex, diagnosis (granulomatosis with polyangiitis (GPA) vs. microscopic polyangiitis (MPA)), and familial fa

academic.oup.com

True or False: Jaccoud's arthropathy causes joint deformities due to bone and cartilage damage, and erosions are typically visible on X-ray. Test your knowledge in this week's RheumIQ at rheumnow.com/game.

Cochrane review of cLBP Rx (8 RCTs, 501 pts) show Lumbar supports may result in a small reduction in pain intensity if given w/ NSAIDs, but offer little to no benefit for pain intensity & disability alone. Insufficient evidence to support their routine use. www.cochranelibrary.com/cdsr/doi/10....

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015492.pub2/full

cochranelibrary.com

NY Times reports Gallop poll: 15% Americans used a wt-loss drug (11% currently taking) - up from 3% in 2024. These have been approved for use in NIDDM, weight loss, liver Dz, CV risk reduct. & sleep apnea. Also obesity in USA is fell to 36.4% (peak 39.9% in 2022) www.nytimes.com/2026/07/07/w...

NEJM images: Jaccoud’s arthropathy is a chronic, deforming;from laxity of the ligaments & tendons (not damage to bone & cartilage). Deformities are reducible & no erosions on Xray. Jaccoud’s mimics RA, but most seen w/ SLE. buff.ly/qcLLzam

Korean retrospective study compared NIDDM pts Rx w/ SGLT2 inhibitor (n 552,065) vs sulfonylurea (1,480,092) showed SGLT2 inhibitors were assoc w/ a signif 11% lower risk of incident autoimmune dz (HR 0.89). Diff of −6.50 per 100K PYs over median ~9 mos F/U. pmc.ncbi.nlm.nih.gov/articles/PMC...

Lupus Research Alliance has awarded >$2 million in 2026 awards to studying innovative lifestyle interventions for people living with lupus. This includes studies on ginger supplementation, physical activity, and a whole health online programs buff.ly/oHV1uDQ

Novartis & BMS CAR-T Cell Trials on Hold Reuters and the Wall Street Journal report that both Novartis and Bristol Myers Squibb (BMS) have paused their autoimmune disease CAR-T cell trials due to safety concerns, including deaths. buff.ly/qzCfjIW

MSK problems w/ Mobile gaming addiction (MGA)? Study of 364 Jordanian med students saw 9% w/ MGA; MGA signif more UE MSK pain (71% vs 48%; p 0.012) vs nonaddicts. Elbow pain (41%) best predictor of MGA, but also neck (85%), upper back (65%), wrists (41%). openpublichealthjournal.com/VOLUME/19/EL...

Investigating Mobile Gaming Addiction and Musculoskeletal Pain: A Cross-Sectional Study Among Medical Students in Jordanian Universities

Investigating Mobile Gaming Addiction and Musculoskeletal Pain: A Cross-Sectional Study Among Medical Students in Jordanian Universities

openpublichealthjournal.com

Novartis & BMS CAR-T Cell Trials in autoimmune diseases are put on hold with concerns about safety and 3 deaths. rheumnow.com/news/novarti...

Novartis & BMS CAR-T Cell Trials on Hold | RheumNow

Reuters and the Wall Street Journal report that both Novartis and Bristol Myers Squibb (BMS) have paused their autoimmune disease CAR-T cell trials due to safety concerns, including deaths.

rheumnow.com

Chinese retrospective study of 140 Bx proven Kikuchi-Fujimoto pts shows very few evolve into #SLE. While 60% were ANA+ (11.3% other autoAbs) - none developed SLE (median F/U 39mos). KFD is benign, self limiting necrotizing lymphadenitis usually in young women. onlinelibrary.wiley.com/doi/10.1002/...

Clinical significance of antinuclear antibodies in patients with Kikuchi‐Fujimoto disease: A retrospective cohort study

A total of 140 Kikuchi-Fujimoto disease (KFD) patients were included (ANA positivity 62.1%), of whom 10 had concurrent rheumatic diseases. Among the remaining 130 patients without rheumatic…

onlinelibrary.wiley.com

Necrotizing arteritis is rare w/ IgA Vasculitis (IgAV). Review compared 30 IgAV-NA to 257 adult IgAV & 196 PAN pts. Overall IgAV-NA is a severe IgAV phenotype with life-threatening complications & should prompt vascular imaging and intensified immunosuppression. www.tandfonline.com/doi/10.1080/...

The global inflammatory myopathies market size was valued at USD 1.81 billion in 2025 and is expected to reach USD 2.67 billion by 2033 (CAGR of 5.00%). This applies to: Polymyositis, Dermatomyositis, Inclusion Body Myositis, Juvenile Myositis dbmresear.blogspot.com/2026/08/infl...

Inflammatory Myopathies Market: Industry Size, Share, Autoimmune Therapeutics Trends, and Forecast by 2033

" According to the latest report published by Data Bridge Market Research, the Inflammatory Myopathies Market   CAGR Value  The global in...

dbmresear.blogspot.com

Korean National Health Insurance claims study of 4,107 newly Dx gout on allopurinol x 24 mos (vs non-gout controls). Gout significantly higher risk of fractures (aHR 5.52_; 95% CI 4.19–7.26). Consistent trends seen for vertebral (aHR 5.68) & hip (aHR 4.22) Fx link.springer.com/article/10.1...

Gout and allopurinol adherence in newly diagnosed patients and the risk of fractures: a nationwide cohort study - Clinical Rheumatology

Introduction / Objectives The association between gout and fractures remains controversial due to the competing effects of uric acid's antioxidant properties and gout-induced chronic inflammation.…

link.springer.com

VA registry study of 2723 RA pts showed frailty was independently assoc w/ incr cancer incidence. Age-adjusted CA incidence rates (per 1,000PYs): 12.3 (robust), 15.5 (pre-frail), and 19.9 (frail). CA mortality rates were 7.8, 10.6, & 9.8/1,000PYs acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

SELECT-PsA 2 subanalysis of 195 active PsA not responding to TNFi shows switching to upadacitinib 15 (vs PB) was superior @wk 24 - ACR20 (58% vs 22%), ACR50 (38% vs 9.5%), ACR70 (22% vs 0%), MDA (24% vs 3%) & maintained thru wk 152. Switching MOAs makes sense! buff.ly/EMFj2Yi

Metanalysis looked at neutrophil to Lymph ration (NLR) in SLE - 31 studies, 4,006 SLE pts. NLR signif incr in SLE worldwide. NLR was higher in Active vs inactive SLE, and showed a significant but moderate correlation w/ SLEDAI (CC=0.354, p < 0.001). journals.sagepub.com/doi/abs/10.1...

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

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5 Idiopathic inflammatory myopathypts Rx w/ obinutuzumab for refractory myositis (2 antisynthetase syndr, 1 DM, 2 overlap myositis). 4/5 patients achieved complete response. Lung improved/stabilized in ILD pts. No hypogammaglobulinemia, SIE, or hospitalizations academic.oup.com/rheumatology...

Real-world experience with obinutuzumab in difficult-to-treat myositis: concise report of a case series

AbstractObjectives. Idiopathic inflammatory myopathy (IIM) is an orphan systemic disorder with muscular, cutaneous and pulmonary involvement. B cell-direct

academic.oup.com

Ro52 Abs in idiopathic inflammatory myopathies (IIM). From 2,126 IIM China/Japan pts, Ro52 positivity was common (46%), esp in MDA5+ DM & anti-synthetase syndr (ASyS) & was assoc w/ high freq of ILD, rapidly progressive ILD, and poor prognosis. academic.oup.com/rheumatology...

Anti-Ro52 antibodies in idiopathic inflammatory myopathies: clinical significance across myositis-specific antibody-defined subgroups

AbstractObjective. To investigate the frequency, clinical characteristics, and prognostic value of anti-Ro52 antibodies in patients with idiopathic inflamm

academic.oup.com

Resolved HBV infx (HBsAg-neg/anti-HBc+) retro study of HBc seroclearance in 230 pts Rx w/ anti-CD20 mAb. anti-HBc seroclearance in 16.5% (esp Younger, less CD20 Rx, MMF Rx). HBV reactivation seen 5/230 (2.2%), including two w/ HBc seroclearance. www.mdpi.com/1648-9144/62...

https://www.mdpi.com/1648-9144/62/9/1659

mdpi.com

JAK inhibitors work & have a dose dependent effect in severe alopecia areata (AA). Metanalysis of 10 Rxs, 3866 AA pts (used the SALT20 endpoint) showed the best efficacy was deuruxolitinib_12 mg, and baricitinib_4 mg (OR: 2.59, 95% CI: 1.98–3.38). academic.oup.com/pmj/article-...

Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials

AbstractBackground. Alopecia areata (AA), an autoimmune disorder, represents a prevalent form of hair loss among individuals. Various therapeutic approache

academic.oup.com

Per adult-onset IgA vasculitis guidelines, which agent is now preferred for refractory or relapsing disease? Test your knowledge in this week's RheumIQ at rheumnow.com/game.

FDA Approves Brepocitinib for Dermatomyositis in Adults. Marketed as "Lisraya" it is a once-daily oral tablet that is a JAK/TYK2 inhibitor. Brepocitinibs efficacy was proven in the Ph III VALOR study of 241 DM pts Rx 52-weeks w/ both skin, motor and functional benefits. www.fda.gov/news-events/...

FDA Approves First Oral Drug Indicated to Treat Dermatomyositis in Adults

The U.S. Food and Drug Administration has approved Lisraya (brepocitinib) tablets for the treatment of dermatomyositis in adults.

fda.gov

Japanese study of 101 864 kids shows fertility treatments (ovulation induction, intrauterine insemination, invitro fertilization) increases the risk of Kawasaki Dz. Incidence rates per 100K PYs - 274 for spont conception vs 391 for assisted conception (adj HR 1.42) jamanetwork.com/journals/jam...

Fertility Treatments and the Risk of Kawasaki Disease Among Offspring

This nationwide birth cohort study uses data from the Japan Environmental and Children’s Study to examine the association between fertility treatments and the risk of Kawasaki disease among offspring…

jamanetwork.com

Phase 1/2 COMPARE trial of CD19 CAR-T Rx in 6 ACPA+ RA pts w/ severe refractory Dz; after lymphodepletion, followed < 52wks. All had CRS, No ICANSs or serious AEs. All had CD19 cell depletion & Decr in AutoAbs. Efficacy: 3/6 had ACR70 & Dz activity improved www.nature.com/articles/s41...

CD19 CAR T cell therapy for treatment-refractory seropositive rheumatoid arthritis: a phase 1 trial - Nature Medicine

In the phase 1 part of the ongoing phase 1/2 COMPARE trial, CD19 CAR T cell treatment of patients with severe, treatment-refractory rheumatoid arthritis was well tolerated with clinical improvement…

nature.com

The Scleroderma Research Foundation (SRF) will konor John Stamos with the Bob Saget Legacy Award at this year's "Cool Comedy • Hot Cuisine" ceremony that will take place Tuesday, Oct 13th at Beverly Wilshire in Los Angeles. Proceeds will support the SRF pr.augustabusinessdaily.com/article/The-...

Augusta Business Daily

Business News for Augusta, GA

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Aortic inflammation (Aortopathies) occurs in autoimmune rheumatic diseases (ARD) including Takayasus, #GCA, SLE, RA, AS, SSc, relapsing polychondritis, Cogan’s syndr, Behçet’s, & IgG4-related disease). Dx imaging options: CTA, MRI, & PET/CT. infiltrates www.mdpi.com/2075-4418/16...

https://www.mdpi.com/2075-4418/16/17/2709

mdpi.com