𝐇𝐨𝐰 𝐝𝐨 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐚 𝐭𝐮𝐫𝐧 𝐡𝐨𝐬𝐭 𝐬𝐭𝐫𝐞𝐬𝐬 𝐢𝐧𝐭𝐨 𝐯𝐢𝐫𝐮𝐥𝐞𝐧𝐜𝐞 𝐩𝐫𝐨𝐠𝐫𝐚𝐦𝐬? A new study in @natcomms.nature.com shows that Fe-S cluster damage activates the stringent response in 𝑆𝑎𝑙𝑚𝑜𝑛𝑒𝑙𝑙𝑎, 𝐸𝑛𝑡𝑒𝑟𝑜𝑏𝑎𝑐𝑡𝑒𝑟 and 𝐾𝑙𝑒𝑏𝑠𝑖𝑒𝑙𝑙𝑎. ✍️ @sronneau.bsky.social & coll. 📖 shorturl.at/zP3BB #Microbiology #StringentResponse #ppGpp

Happy to share our lastest story about the Stringent Response ! We show how host-relevant stress disrupts Fe-S cluster stability, tuning (p)ppGpp levels to control bacterial adaptation and trigger virulence. Read more here 👉 www.biorxiv.org/content/10.1...

Stress-Induced Iron-Sulfur Cluster Damage as a Conserved Trigger of the Stringent Response

Pathogenic bacteria rely on the stringent response to adapt to the complex and fluctuating conditions encountered within the host. However, the mechanisms by which the stringent response senses host-i...

biorxiv.org

Excited to share our latest work on antibiotic persistence ! We found that while bacteria intoxicated by host RNS are shielded from β-lactams, they still remain vulnerable to fluoroquinolones. Why? Check our new study : journals.plos.org/plospathogen...

Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection

Author summary By influencing the physiology of bacterial pathogens, the host environment can either limit or potentiate the effectiveness of antibiotics during infection. Recently, we demonstrated th...

journals.plos.org

The HintonLab SalCom transcriptomic databases are back on online TODAY❗️#Salmonella SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack

Highly recommend this excellent review from Katherine Cotten and Kimberly Davis about antibiotic persistence during infection. Really happy to see that we are moving forward in this challenging field !