Join Stanford Chem for this year's McConnell Lecturer in Chemistry: Prof. Lewis E. Kay (Univ. of Toronto), a pioneer in biomolecular NMR. He’ll present “The Essentiality of Solution NMR Spectroscopy in the Post-Alpha Fold Era,” May 5, 3–4 PM, Sapp Center 114. chemistry.stanford.edu/events/mccon...

Excited to have Edric Choi present his latest work on RNA chemical mapping at the CASP Nucleic Acids Reading Group! Thursday April 16 2026 on Zoom; Pacific Daylight Saving Time 8 am / Eastern Daylight Saving Time 11 am -- free to attend and full of interactive discussions.

This week, learn about the crowdsource RNA design platform, Eterna, and Anthony Stohr's switch work. In the future, how could Eterna be used to tackle to 3D RNA structure problem? Meeting ID: 934 4593 5624 Passcode: 802843 Mailing list: groups.google.com/g/casp-rna-sig

To understand biology is to accurately predict it—measured in double-blind expirements like CASP. As methods improve and experiments expand, we ask harder, more biologically relevant questions. Submit your structures/ensembles to CASP17! I’ve provided (RNA) targets before and am happy to chat.

Torsten Schwede@torstenschwede.bsky.social · 5mo ago

Is #AI hitting a plateau in structure prediction? Help us find out at CASP17! 🧪🧬 Calling for Targets: Immune Complexes, protein - ligand complexes, RNA/DNA, conformational ensembles, membrane proteins, viral origins, and large complexes. The Rule of Thumb: If AF3 can’t model it, we want it.

Come learn all about RNAnneal from Pratyush Tiwary this Thursday! RNA structure + ensembles what could be more interesting (preprint: www.biorxiv.org/content/10.6...) Meeting ID: 934 4593 5624 Passcode: 802843 Mailing list: groups.google.com/g/casp-rna-sig

Come learn about super interesting and cool DNA structure at our nucleic acid structure webinar by Cameron Mackereth "Unusual DNA architecture in a dopamine-bound aptamer complex" on March 5 Meeting ID: 934 4593 5624 Passcode: 802843 Mailing list: groups.google.com/g/casp-rna-sig

Come learn about new tricks with DMS next week at our nucleic acid structure webinar by Tony Mustoe "Teaching an old dog new tricks: Using DMS to map higher-order RNA structures and folding thermodynamics" Meeting ID: 934 4593 5624 Passcode: 802843 Mailing list: groups.google.com/g/casp-rna-sig

Please join us for our next nucleic acid structure webinar, "Template-based RNA structure prediction advanced through a blind code competition," presented by Rhiju Das, G. John Rao, Toshiyuki Oda, Yehyun Kim, Raehyun Kim, Hyunkin Kim. Mailing list: groups.google.com/g/casp-rna-sig

Very excited for our next webinar in 1 week featuring Hani Goodarzi discussing "Building Structure-Aware Models of RNA-Protein Interactions Through Explicit Context-Free Grammar Encoding". Mailing list: groups.google.com/g/casp-rna-sig

Join us for our next seminar featuring Marta Szachniuk, one of the leading experts in the computational biology of RNA 3D structure. She will discuss RNA entanglements. Mailing list: groups.google.com/g/casp-rna-sig

The beauty of symmetric, homo-oligomeric biomolecular complexes cannot be denied— nature builds these from RNA as well! Here’s to the years ahead, as the community uncovers what these assemblies can teach us about RNA biophys and functions, and how they may inspire future biotechnology.

RCSB Protein Data Bank@rcsbpdb.bsky.social · 7mo ago

Large and intricate naturally occurring structures composed exclusively of RNA... ROOL! More at Molecule of the Month: pdb101.rcsb.org/motm...

On Wednesday join us for our next Nucleic Acid Structure webinar by Dr Yun-Xing Wang "Snapshot structure vs. conformational space of RNA under physiologically relevant Mg2+ concentrations" This will not be recorded please join live. Join the mailing list groups.google.com/g/casp-rna-sig

Registration to the next RNA BENASQUE meeting July 05-17 2026 is open. benasque.org/2026rna/ Yes, Benasque is my profile pic. This #RNA meeting puts together for 2 weeks researchers in computational methods for structural RNA. 9th edition already! #RNAsky

Indeed this seminar will be given by none other than the amazing George Ghanim @automnenine.bsky.social , come learn about how human retrotranposons work and interact with their target DNA

George Ghanim@automnenine.bsky.social · 11mo ago

Hey thats me.

We have restarted our global Nucleic Acid Strcuture webinar series to bring the expiremental and computational communities together to discuss new developments in the field. Join us this Thursday for the next webinar. Sign up to our mailing list here: groups.google.com/g/casp-rna-sig

When I determed OLE's structure, a transmembrane RNP was staring at me. Took a little bravery to propose this in our manuscript, so I am stoked to see the experts elaborate further. Past data does not rule out OLE RNA spanning the membrane, but data is still needed. Excited for future OLE studies!

Anton Petrov@antonipetrov.bsky.social · last yr.

🤯 Implications for OLE RNA as a natural integral membrane RNA from Ron Breaker's lab rnajournal.cshlp.org/content/earl...

Nucleic acid structural biologists expose that many CASP16 predictions, even ones obtaining high scores by CASP metrics, are inaccurate in the most functionally relevant regions! Read more insights on functionally relevant features by the expert structure determiners (doi.org/10.1101/2025...).

Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers

Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, exper...

doi.org

What is the status of nucleic acid structure prediction? Our analysis of CASP16 (doi.org/10.1101/2025...) reveals human expertise is still necessary for the most accurate prediction, but accuracy still heavily relies on templates; having seen a similar structure already.

Assessment of nucleic acid structure prediction in CASP16

Consistently accurate 3D nucleic acid structure prediction would facilitate studies of the diverse RNA and DNA molecules underlying life. In CASP16, blind predictions for 42 targets canvassing a full ...

doi.org

With the CASP16 season over (and a defense behind me), I am very excited to say we will be restarting the nucleic acid SIG webinar + discussion series! We are actively recruited speakers and co-organizers, get in touch! Read our short piece about the impact of SIG here: doi.org/10.1002/prot...

Engaging the Community: CASP Special Interest Groups

The Critical Assessment of Structure Prediction (CASP) brings together a diverse group of scientists, from deep learning experts to NMR specialists, all aimed at developing accurate prediction algori...

doi.org

The next #CryoEM Current Practices Webinar speaker will be Rachael Kretsch from Stanford speaking on "RNA cryo-EM: unveiling the wonders of RNA biology" 2/27/25 at 12PM ET/9AM PT. Register today: us02web.zoom.us/webinar/regi... Learn more about the NIH sponsored cryoEM resources: cryoemcenters.org

Curious about how ensembles have shaped our fundamental understanding of enzyme mechanisms? Check out this amazing work led by Siyuan Du, now published! Congrats all! www.science.org/doi/10.1126/...

Check out preprint: www.biorxiv.org/content/10.1...

Complex Water Networks Visualized through 2.2-2.3 Angstrom Cryogenic Electron Microscopy of RNA

The stability and function of biomolecules are directly influenced by their myriad interactions with water. In this study, we investigated water through cryogenic electron microscopy (cryo-EM) on a hi...

biorxiv.org

Rachael Kretsch@rachael-kretsch.bsky.social · 2y ago

Check out our new study on water networks in high resolution cryo-EM RNA data! @ Chiu Lab @ Das Lab

Check out our new study on water networks in high resolution cryo-EM RNA data! @ Chiu Lab @ Das Lab

We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024... Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Rhiju Das, Wah Chiu