Elena Rivas

@rivaselenarivas.bsky.social

computational biologist. algorithms for genomics. worried about sustainability: from personal 2 country 2 planet. 🧪🧬| http://rivaslab.org

The Chen Lab @ EMBL Rome (current population: 1) is hiring! Looking for an experimental Lab Manager w/ a PhD and experience in molecular bio and mouse-based neuro research. Apply if you like: mouse behaviors, high-throughput sequencing, good coffee & ancient history tinyurl.com/48h66vfh

Lab Manager

The European Molecular Biology Laboratory (EMBL) is one of the world’s leading life science research organizations. With sites across Europe, EMBL fosters an international, collaborative, and inclusiv...

tinyurl.com

All 100+ participants arrived safely to Benasque for the workshop "Computational Approaches to RNA Structure and Function" Looking forward to our opening talk "RNA structure 3D prediction and cryo-EM structures" by Rachael Kretsch, and to our meeting to organize the rest of talks and interactions.

Bild

🚀 We're hiring a 𝗕𝗶𝗼𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗰𝘀 𝗗𝗮𝘁𝗮 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿 to run, maintain and optimise pipelines behind Rfam and RNAcentral, including development of LLMs, agent orchestration workflows, and more! Apply by 28 June👇 embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #RNA #Bioinformatics #AI #DataEngineering #job

Bioinformatics Data Engineer (RNA Resources)

About the Team Rfam and RNAcentral are key resources for RNA biology, serving tens of thousands of users every year and widely cited in the scientific literature. We are recruiting a Bioinformatics Da...

embl.wd103.myworkdayjobs.com

Integrated prediction of RNA secondary structure jointly with 3D motifs and pseudoknots guided by evolutionary information. @aakaran31.bsky.social and @rivaselenarivas.bsky.social link.springer.com/article/10.1...

All-at-once RNA folding with 3D motif prediction framed by evolutionary information - Nature Methods

Structural RNAs exhibit a vast array of recurrent short three-dimensional (3D) elements found in loop regions involving non-Watson–Crick interactions that help arrange canonical double helices into tertiary structures. Here we present CaCoFold-R3D, a probabilistic grammar that predicts these RNA 3D motifs (also termed modules) jointly with RNA secondary structure over a sequence or alignment. CaCoFold-R3D uses evolutionary information present in an RNA alignment to reliably identify canonical helices (including pseudoknots) by covariation. Here we further introduce the R3D grammars, which also exploit helix covariation that constrains the positioning of the mostly noncovarying RNA 3D motifs. Our method runs predictions over an almost-exhaustive list of over 50 known RNA motifs (‘everything’). Motifs can appear in any nonhelical loop region (including three-way, four-way and higher junctions) (‘everywhere’). All structural motifs as well as the canonical helices are arranged into one single structure predicted by one single joint probabilistic grammar (‘all-at-once’). Our results demonstrate that CaCoFold-R3D is a valid alternative for predicting the all-residue interactions present in a RNA 3D structure. CaCoFold-R3D is fast and easily customizable for novel motif discovery and shows promising value both as a strong input for deep learning approaches to all-atom structure prediction as well as toward guiding RNA design as drug targets for therapeutic small molecules.

link.springer.com

Vaccines have one of the highest reward to risk ratios of any medical intervention in human history. This sociopathic conspiracy theorist is literally killing people, causing the deaths by vaccine-preventable diseases of people who could have lived.

jamelle@jamellebouie.net · last yr.

there is no question in my mind that rfk jr is the most dangerous person in this administration and that his eugenicist ideology threatens the lives of millions of people www.advocate.com/politics/dem...

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪 www.richmondscientific.com/how-a-discov...

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific

A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

richmondscientific.com