I’m looking to hire one or two postdocs - possible projects include pop gen theory, methods development, and human evolutionary inference. Please share, and email if you are interested. More info: evoldir.net/brian/evoldi...

New from @gvbarroso.bsky.social in our lab: quantifying the relative importance of mutation rate variation and background selection to levels of diversity along the human genome.

bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social · 2mo ago

Causal inference clarifies the roles of background selection and mutation rate variation in shaping human genetic diversity https://www.biorxiv.org/content/10.64898/2026.06.02.727906v1

Organisers - @gvbarroso.bsky.social | @uwmadison.bsky.social / Universidad de Vigo - @goldmich.bsky.social | @utah.edu - @pyjiang.bsky.social | Arizona State University - @apragsdale.bsky.social | @uwmadison.bsky.social Invited Speaker - Peter Keightley | @edinburgh-uni.bsky.social

Together with Pengyao Jian, Michael Goldberg and Aaron Ragsdale, I am organizing a symposium in SMBE Copenhagen: “Causes and consequences of mutation rate variation” with Peter Keightley as invited speaker! It’s high time we discuss this critical topic, abstract submission opens Dec 1 smbe2026.org

Abstracts & Awards - SMBE 2026 - Copenhagen Denmark

SMBE 2026 Abstract Submission abstract Submitting an abstract Here is an overview of the abstract submission.  Length and words: The abstract must be submitted in English and should be less than 250 w...

smbe2026.org

Stable hypermutators revealed by the genomic landscape of DNA repair genes among yeast species https://www.biorxiv.org/content/10.1101/2025.03.15.643480v1

And now recommended at PCI Evolutionary Biology!! @peercommunityin.bsky.social evolbiol.peercommunityin.org/articles/rec... Big thanks to co-authors, recommender and reviewers!!

David Castellano@castellanoed.bsky.social · 2y ago

Short thread on my updated work with @gutengroup.mcb.arizona.edu "Detection of Domestication Signals through the Analysis of the Full Distribution of Fitness Effects", latest version at: www.biorxiv.org/content/10.1... Here we simulate a kind of canonical and idealised domestication process.

VERY excited to announce a pre-print that represents the culmination of several years of work*: “On ARGs, pedigrees, and genetic relatedness matrices” doi.org/10.1101/2025... Led by Brieuc Lehmann with contributions from @epigenci.bsky.social Luke Anderson Trocme Jerome Kelleher and Peter Ralph

On ARGs, pedigrees, and genetic relatedness matrices

Genetic relatedness is a central concept in genetics, underpinning studies of population and quantitative genetics in human, animal, and plant settings. It is typically stored as a genetic relatedness...

doi.org

Low accuracy of complex admixture graph inference from f-statistics https://www.biorxiv.org/content/10.1101/2025.03.07.642126v1

peercommunityjournal.org/articles/10....

A model for background selection in non-equilibrium populations https://www.biorxiv.org/content/10.1101/2025.02.19.639084v1