Zachary Susswein

@zsusswein.bsky.social

I spend entirely too much time thinking about GAMs https://github.com/zsusswein

🚨 Disease modelers: Do you use empirical VE estimates interchangeably to inform vaccine effect parameters? Me too, and it’s distorting our predictions. VE estimates often do not align with model parameters. We discuss these pitfalls & solutions in our new preprint: arxiv.org/abs/2605.18571 🧵👇

Incorporating vaccine effects into epidemiological models: common pitfalls and solutions

Incorporating vaccination into mathematical models appears deceptively simple: models integrate vaccine-derived protections, such as reduced susceptibility to infection, using parameters informed by e...

arxiv.org

Models can be powerful tools to study associations in data. But do they reliably reveal the truth? 🚨 In our new study, @danlarremore.bsky.social and I show that the model used to estimate VE from test-negative designs (TNDs) may not translate to other correlates of risk. doi.org/10.1093/aje/...

Statistical methods for estimating the protective effects of immune markers using test-negative designs

Abstract. While widely used to study vaccine effectiveness, test-negative designs (TNDs) also provide a platform for identifying and quantifying immunologi

doi.org

🚀 gratia 0.11.0 is out! Now has a paper in JOSS — please cite 📄 doi.org/10.21105/jos... Experimental parallel processing ⚡ New assemble() for building plots 🎨 Better support for complex families + new diagnostics 🧪 Lots of bug fixes + polish ✨ 👉 gavinsimpson.github.io/gratia/ #Rstats

An R package for working with generalized additive models

Graceful 'ggplot'-based graphics and utility functions for working with generalized additive models (GAMs) fitted using the 'mgcv' package.

gavinsimpson.github.io