Luke Pattison
@interlukein.bsky.social
Research scientist investigating inflammatory pain 🔬 📍 Melbourne 🇦🇺
Really excited to share out latest preprint! We’ve been studying how the proton-sensing GPCR GPR65 drives inflammatory pain – and found that *where* it signals matters! Huge thanks to support from @mayadannawi.bsky.social and @psalmotoxin.bsky.social! Read here: www.biorxiv.org/content/10.6...
Still time to submit your latest work on #inflammatorypain to our special issue of Cells focussed on the Molecular Mechanisms of Inflammatory Pain. We’re accepting manuscripts until September - if you have something suitable in the pipeline, please get in touch!
At 13:00 our @phar.cam.ac.uk lab will be live @sfn.org! Poster N3 sees @mayadannawi.bsky.social presenting on overexpression of Prdm12 in the adult sensory nervous system Poster O6 sees @interlukein.bsky.social presenting on loss of Piezo2 in colonic sensory neurons with age Please drop on by 😃
New pre-print from @phar.cam.ac.uk & Bellefroid lab at ULB! Led by @mayadannawi.bsky.social w support from @interlukein.bsky.social & more! We investigate impact of overexpressing the zinc finger transcriptional regulator Prdm12 on sensory neuron function / joint pain. #neuroskyence #PainResearch
AAV-mediated overexpression of Prdm12 in knee-innervating afferents reduces inflammatory joint pain and neuronal hyperexcitability in mice
Inflammatory joint pain features in numerous musculoskeletal disorders that affect millions globally. The Prdm12 gene encodes a conserved zinc finger transcriptional regulator expressed selectively in...
biorxiv.org
Great summary of our latest work - a real Team Science effort! 👥 🐭
Osteoarthritis and Cartilage Journal@oacjournal.bsky.social · 12mo ago#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability. @psalmotoxin.bsky.social @interlukein.bsky.social @mayadannawi.bsky.social
I am currently curating a Special Issue for MDPI Cells on “Molecular Mechanisms Underlying Inflammatory Pain.” If you are working on, or planning a suitable manuscript, I would be delighted if you would consider submitting it to our issue. mdpi.com/journal/cell...
A new academic year! 🍏 Proud to watch my Pegasus Scholars students presenting on targeted cancer therapies today, after a week exploring the formation, functions, faults and fixing of proteins! 🔬 Glad to support Robinson College’s excellent widening participation initiation for another year! 👨🏫
If you have #osteoarthritis, please see below 👇 - I’m running a 2 minute survey and would love your input 😇
Luke Pattison@interlukein.bsky.social · last yr.👋I’m developing a proposal to investigate how pain changes with progression of osteoarthritis (OA). 🦴⚡️ If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏 forms.office.com/e/pYwbTrD3Qv
👋I’m developing a proposal to investigate how pain changes with progression of osteoarthritis (OA). 🦴⚡️ If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏 forms.office.com/e/pYwbTrD3Qv
Microsoft Forms
forms.office.com
📣 Calling fellow ECRs studying the contributions of GPCRs to pain and/or analgesia! 🧠 Interested in presenting at #SfN25 in San Diego in November? 🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal! #PainResearch #neuroskyance
📣 Calling fellow ECRs studying the contributions of GPCRs to pain and/or analgesia! 🧠 Interested in presenting at #SfN25 in San Diego in November? 🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal! #PainResearch #neuroskyance
Riding the year out on a high ✨ - latest paper out now in @pnas.org! ☺️ 🙏 Here we describe a role for the proton-sensing GPCR, GPR65 in mediating joint pain from fibroblast-like synoviocytes! www.pnas.org/doi/10.1073/... #PainResearch #Neuroskyence More on this work below 👇 🧵 [1/10]
Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain | PNAS
Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton-sensitive receptors is chal...
pnas.org
Excellent walk-through of our latest work, looking at lipids and inflammatory joint pain 👇
Ewan St. John Smith@psalmotoxin.bsky.social · 2y agoPain = main driver of clinical decision making in osteoarthritis (OA). Our lab studies OA pain mechanisms. During OA, multiple cell-cell interactions occur, many mediators being released that alter the contents of the synovial fluid. #PainResearch #Neuroskyence journals.lww.com/pain/Fulltex...
👋 Hello, I'm new here... ...followed the herd to a greener field! 🐏 🦋 I'm a postdoc interested in the mechanisms driving inflammatory pain, with the aim of identifying new points of intervention, for the development of better medicines! #PainResearch #FirstPost
