Mark Wagner

@mark-j-wagner.bsky.social

Neuro PI @NIH https://irp.nih.gov/pi/mark-wagner Stadtman Investigator

The cortex and cerebellum split the labor: the cortex provides a stable, general-purpose movement blueprint, while the cerebellum reorients that same blueprint differently for each context Granule cells reorient cortical trajectories to separate contexts www.nature.com/articles/s41... #neuroscience

Granule cells reorient cortical trajectories to separate contexts - Nature

Simultaneous imaging of premotor cortex and cerebellar granule cells in mice learning two skills in parallel shows that trajectories generalize in cortex but coherently reorient apart in granule cells...

nature.com

How does the brain generalize past experiences without confusing memories? 🧠 Our lab's newest preprint reveals a fundamental division of labor between the cortex and cerebellum that solves this problem. (Check out the cortex-cerebellum video below! 👇) 🧵