Neurobiology of Aging
@neurobiology-aging.bsky.social
NBA publishes behavioral, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry studies of aging or diseases associated with age.
✨ SHINY NEW PAPER ✨ Relative to younger adults, pupil dilation was not associated with memory performance in older adults and their attenuted phasic pupil responses may reflecting impaired locus coeruleus modulation with age www.sciencedirect.com/science/arti...
sciencedirect.com
✨ SHINY NEW PAPER ✨ Using @ukbiobank.ac.uk data, aorta and carotid artery structure mediated effects of cardiovascular risk factors (strongest for total cholesterol) on rates of brain aging measured with longitudinal neuroimaging www.sciencedirect.com/science/article/pii/S019745802600059X
📚 NEW ISSUE 📚 Articles cover links between epigenetic age and motor impairment, GFAP and APOE e4, handgrip and cognitive decline, pupil dynamics and memory, and more. www.sciencedirect.com/journal/neur...
sciencedirect.com
✨ SHINY NEW PAPER ✨ When brain Age Gap (BAG) incorporates metabolic and physiological blood test parameters, it is more strongly associated with amyloid-β accumulation and cognitive function www.sciencedirect.com/science/arti...
Exploratory analysis of the associations of the brain age gap with cognitive function and amyloid-β accumulation: participants selection based on metabolic and physiological blood markers
The brain age gap (BAG) is defined as the difference between brain age estimated from MRI using artificial intelligence and chronological age, and has…
sciencedirect.com
✨ SHINY NEW PAPER ✨ More ferritin-positive microglia that cluster near vasculature in MCI and AD suggests that early microglia activation in response to vascular injury may be a precursor to local neuritic tau development. www.sciencedirect.com/science/arti...
sciencedirect.com
✨ SHINY NEW PAPER ✨ Diffusion Tensor Imaging along the Perivascular Space (DTI-ALPS) may reflect local tissue fluid changes and microstructural damage in small vessel disease following stroke www.sciencedirect.com/science/arti...
sciencedirect.com
📚 NEW ISSUE 📚 Articles cover dopaminergic degeneration in Parkinson's Disease, brain age gap in relation to cognition and amyloid accumulation, diffusion imaging of small vessel disease, and more. www.sciencedirect.com/journal/neur...
Neurobiology of Aging | Vol 163, Pages 1-64 (July 2026) | ScienceDirect.com by Elsevier
Read the latest articles of Neurobiology of Aging at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
sciencedirect.com
✨ SHINY NEW PAPER ✨ PET study shows that serotonergic and glutamatergic receptor–dense regions may have a preferential metabolic vulnerability in Alzheimer’s Disease www.sciencedirect.com/science/arti...
Neurotransmitter landscape and neurodegeneration patterns in Alzheimer’s Disease
Alterations of neurotransmitter systems in Alzheimer’s Disease (AD) remain partially understood, mainly due to the complexity of simultaneously and di…
sciencedirect.com
✨ SHINY NEW PAPER ✨ Sex-specific factors may explain why older women are overrepresented in observational research and men are overrepresented in clinical trials. @mcgill.ca www.sciencedirect.com/science/arti...
sciencedirect.com
✨ SHINY NEW PAPER ✨ Category learning performance in older adults is better explained by a prototype than exemplar model even though they engaged the hippocampus and prefrontal cortex similarly to younger adults www.sciencedirect.com/science/arti...
sciencedirect.com
✨ SHINY NEW PAPER ✨ A new open dataset is being created to probe biological, psychological and sociocultural aspects of resilience in the aging brain. @shen4brains.bsky.social @alexwiesman.bsky.social @ar0mcintosh.bsky.social www.sciencedirect.com/science/arti...
The Brain Resilience Study protocol: Building a dataset of the biological and sociocultural factors affecting brain health in older adults
Dementia arises from a complex interplay of biological, psychological, and sociocultural factors. However, previous large-scale studies have largely f…
sciencedirect.com
📚 NEW ISSUE 📚 Articles cover effects of sodium intake on memory in aging, altered neurotransmitter systems in Alzheimer's Disease, biological and sociocultural factors affecting brain aging, and more. www.sciencedirect.com/journal/neur...
Neurobiology of Aging | Vol 162, Pages 1-80 (June 2026) | ScienceDirect.com by Elsevier
Read the latest articles of Neurobiology of Aging at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
sciencedirect.com
✨ SHINY NEW PAPER ✨ In older adults, higher daily step counts is associated with better executive functioning and fewer depressive symptoms www.sciencedirect.com/science/arti...
Concurrent associations between visit-to-visit changes in actigraphy-based physical activity and cognitive aging in older adults
Physical activity (PA) is associated with lower dementia risk, yet few studies examine objectively measured PA with concurrently measured brain and co…
sciencedirect.com
Our new paper is out in Neurobiology of Aging! @neurobiology-aging.bsky.social We examined how sleep quality is linked to resting-state brain connectivity across age and sex.Special thanks to Dr.Ian McDonough and our collaborators at The University of Alabama. www.sciencedirect.com/science/arti...
Sleep quality is associated with default mode and salience network connectivity differently across age and sex
Aging and biological sex are critical moderators of sleep quality, which contributes significantly to age-related cognitive decline and Alzheimer’s di…
sciencedirect.com
✨ SHINY NEW PAPER ✨ Scoping review of blood biomarkers of frailty and cognitive decline @krockdoc.bsky.social www.sciencedirect.com/science/arti...
Blood biomarkers of frailty and cognition: A scoping review
Frailty increasingly is recognized as a factor that modifies the relationship between disease biomarkers, including neuropathology, and dementia expre…
sciencedirect.com
✨ SHINY NEW PAPER ✨ Lower frontal white matter hyperintensities predicted better executive function outcomes in vascular MCI participants treated with N-acetylcysteine and exercise @kristalanctot.bsky.social www.sciencedirect.com/science/arti...
Frontal white matter hyperintensity burden predicts cognitive response to N-acetylcysteine and exercise in vascular mild cognitive impairment
Vascular mild cognitive impairment (vaMCI) is a prodromal stage of dementia defined by cognitive deficits due to cerebrovascular disease. Increased wh…
sciencedirect.com
📚 NEW ISSUE 📚 Articles cover blood biomarkers of frailty, MTL network flexibility in older African Americans, actigraphy-based physical activity in aging, and more. www.sciencedirect.com/journal/neur...
Neurobiology of Aging | Vol 161, Pages 1-82 (May 2026) | ScienceDirect.com by Elsevier
Read the latest articles of Neurobiology of Aging at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
sciencedirect.com
✨ SHINY NEW PAPER ✨ A resting-state EEG marker of cortical excitation-inhibition balance (aperiodic exponent) moderated effects of age on episodic and short-term memory @allyneuro.bsky.social www.sciencedirect.com/science/arti...
Resting-state EEG aperiodic exponent moderates the association between age and memory performance in older adults
Memory functions are susceptible to age-related cognitive decline, making it essential to explore the underlying neurophysiological mechanisms that co…
sciencedirect.com
✨ SHINY NEW PAPER ✨ Longitudinal growth rate of white matter hyperintensities (WMH) increases with baseline beta-amyloid burden, but decreased with anti-hypertensive medications www.sciencedirect.com/science/arti...
Regional growth rates of white matter hyperintensities are associated with beta-amyloid burden
There is increasing evidence for an association between white matter hyperintensities (WMH) and brain beta-amyloid deposition. How WMH are longitudina…
sciencedirect.com
📚 NEW ISSUE 📚 Articles cover white matter hyperintensities in relation to cognitive reserve and amyloid burden, light sensitivity in AD, oligodendrogenesis in the aging brain, and more. www.sciencedirect.com/journal/neur...
Neurobiology of Aging | Vol 160, Pages 1-86 (April 2026) | ScienceDirect.com by Elsevier
Read the latest articles of Neurobiology of Aging at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
sciencedirect.com
✨ SHINY NEW PAPER ✨ Whereas the volume of white matter hyperintensities (WMH) typically increases with age and disease, WMH volume can also decrease @wilcocklab.bsky.social www.sciencedirect.com/science/arti...
White matter hyperintensity regression: Fact or artifact?
White matter hyperintensities (WMH) are an MRI-based biomarker associated with aging, Alzheimer’s disease, and vascular dementia. Although the volume …
sciencedirect.com
✨ SHINY NEW PAPER ✨ Iron overload in the aging mouse brain was linked to higher amyloid beta (Aβ) plaque aggregation and worse working memory www.sciencedirect.com/science/arti...
Excess iron may accelerate amyloid beta accumulation in the brains of older mice
Aging is a natural physiological process that may be accompanied by pathological changes, particularly in the brain. Iron is an essential trace elemen…
sciencedirect.com
✨ SHINY NEW PAPER ✨ Evidence of locus coeruleus-noradrenaline (LC-NA) hyperactivity in older adults using behavioral, pupil and EEG data @maramather.bsky.social www.sciencedirect.com/science/arti...
Electroencephalography, pupillometry, and behavioral evidence for locus coeruleus-noradrenaline system related tonic hyperactivity in older adults
Neuroimaging studies have shown that age-related dysregulation of the locus coeruleus-noradrenaline (LC-NA) system is associated with cognitive declin…
sciencedirect.com
✨ SHINY NEW PAPER ✨ Time-restricted feeding in mice reduced age-related hippocampal inflammation and social withdrawal, but had no effect on weight @louise-ince.bsky.social @fonken.bsky.social www.sciencedirect.com/science/arti...
Time-restricted feeding rescues sociability deficits and reduces neuroinflammation in aged mice
The aging brain exhibits an increased inflammatory potential which in turn elicits behavioral changes e.g., social withdrawal. Social isolation is a r…
sciencedirect.com
📚 NEW ISSUE 📚 Articles cover effects of time-restricted eating on inflammation, locus coeruleus hyperactivity, and iron-related amyloid accumulation in aging, and more. www.sciencedirect.com/journal/neur...
Neurobiology of Aging | Vol 159, Pages 1-88 (March 2026) | ScienceDirect.com by Elsevier
Read the latest articles of Neurobiology of Aging at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
sciencedirect.com
✨ SHINY NEW PAPER ✨ Childhood maltreatment modulates (increases and decreases) the effect of age on gray matter volume and moderates the association between age and executive function www.sciencedirect.com/science/arti...
Childhood maltreatment alters associations between age and neurocognitive health metrics in community-dwelling adults
To further understand whether childhood maltreatment (CM) is associated with indicators of accelerated cognitive aging, this study investigated whethe…
sciencedirect.com
✨ SHINY NEW PAPER ✨ Lower tNAA/mIns in hipocampus and posterior cingulate was associated with higher p-tau181/Aβ42 and p-tau181 and lower Aβ42/40 www.sciencedirect.com/science/arti...
1H-MR spectroscopy biomarkers are associated with plasma-derived biomarkers of amyloid-β and tau in the early phase of AD continuum
The objective of the study was to evaluate the relationship of plasma biomarkers of Alzheimer’s disease (AD) with in vivo proton magnetic resonance sp…
sciencedirect.com
✨SHINY NEW PAPER ✨ High depressive symptoms in a diverse cohort of healthy control and MCI participants were linked to higher plasma NfL and p-tau181 levels, but not Aβ42/40 www.sciencedirect.com/science/arti...
Depressive symptoms and plasma AT(N) biomarkers among cognitively healthy and mild cognitively impaired in a diverse cohort
Depression is a known risk factor for dementia and MCI, but its associations with AT(N) biomarkers remain inconsistent and may differ by cognitive sta…
sciencedirect.com
✨ SHINY NEW PAPER ✨ Atlases for tau-PET staging can be optimized by segmenting in native space and smoothing at 6mm www.sciencedirect.com/science/arti...
Optimized atlas for early tau-PET staging via native space segmentations
Positron Emission Tomography (PET) early Braak staging might be susceptible to anatomical variability and atrophy in the medial temporal lobe (MTL) st…
sciencedirect.com
📚 NEW ISSUE 📚 Articles cover optimized atlases for tau-PET staging, depressive symptoms and MR spectroscopy biomarkers of early AD, and more. www.sciencedirect.com/journal/neur...
Neurobiology of Aging | Vol 158, Pages 1-52 (February 2026) | ScienceDirect.com by Elsevier
Read the latest articles of Neurobiology of Aging at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
sciencedirect.com