📣Online now! 📄The impact of Indigenous American-like ancestry on risk of acute lymphoblastic #leukemia in Hispanic/Latino children 🧑‍🤝‍🧑 @charleston.bsky.social @adamdesmith.bsky.social & co 👉 bit.ly/47qXY3Q

📢 Thrilled to see this out, an atlas of e/sQTL across multiple tissues and diverse ancestries in 14,324 TOPMed participants: www.medrxiv.org/content/10.1... Grateful to the #TOPMed #Omics WG for giving me an opportunity to learn and contribute to this important work 🧬

Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed

Most genetic variants associated with complex traits and diseases occur in non-coding genomic regions and are hypothesized to regulate gene expression. To understand the genetics underlying gene expre...

medrxiv.org

Fantastic to have our preclinical study led by Richard Voit and colleagues on a universal gene therapy approach for #DiamondBlackfanAnemia by regulated GATA1 expression published earlier this week: www.cell.com/cell-stem-ce...

Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia

Gene therapy for Diamond-Blackfan anemia is constrained by dozens of causative mutations. Voit and colleagues develop a universal gene therapy through erythroid-lineage-restricted expression of GATA1 ...

cell.com

“Backtracking to the Future” ! Our new article in Leukemia describes the prenatal origins of childhood leukemia, and what we hope to learn by studying patient cord blood samples in the ReCord study (record.umn.edu) rdcu.be/dt7ej

👋 Hi everyone! We're the Center for Genetic Epidemiology, here at Keck School of Medicine, USC! Please follow us for updates on our member's research, community engagement, and activities! Stay tuned for more content 🧬 🧪 💻 👨‍🔬 👩‍🔬

Trying to be better with sharing work on here 😅 Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠

medRxivpreprint@medrxivpreprint.bsky.social · 3y ago

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival https://www.medrxiv.org/content/10.1101/2023.10.15.23296448v1