Bart Smeets

@bart-smeets.bsky.social

Professor of the Multicellular System Dynamics Lab at MeBioS KU Leuven. Interested in mechanobiology, computational modeling, active matter, evolution and more!

New 📄 🚨! #CellBio is teeming with simulations comprising an extraordinarily high number of components. We argue that model complexity will not automatically lead to a better understanding of biological systems & discuss how modeling practices could be repurposed: arxiv.org/abs/2608.06998 #philsci

Simulating is not always understanding: When model complexity obscures biology

In cell biology, computational models of biological systems range from minimal representations with a handful of parameters to whole-cell simulations tracking thousands of molecular species across a c...

arxiv.org

Our paper is out in Nature Communications! We combine two-photon microscopy and active foam modeling to show how cell-scale mechanics control the viscoelasticity and fusion of tissue spheroids, linking single-cell behavior to tissue-level properties. 🔗 www.nature.com/articles/s41... #ActiveMatter

Active foam dynamics of tissue spheroid fusion - Nature Communications

Combining microscopy and modeling, the authors reveal that tissue fluidity, driven by active cell motion and interfacial tension, governs how living spheroids merge into larger structures.

nature.com