Raphael

@raphapalma.bsky.social

Nephrologist/Brazil

🔥🫀ARNI showed superior cardioprotective effects. May have renoprotective effects as per their molecular mechanism, but the evidence to date applies only to heart failure. Future studies in CKD are needed, perhaps? 🤔

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🔥SGLT2 Inhibitors: Game-changers! They reduce HF hospitalisations, preserve GFR, slow CKD progression and improve outcomes in CRS. 🔹 Trials: DAPA-HF, EMPA-KIDNEY show mortality & renal benefits. Do check out the link for the new SGLT2i toolkit there: theisn.org/initiatives/...

Decongestion Therapy 🔹 Loop diuretics = cornerstone 🔹 Use high doses for diuretic resistance; consider thiazides for synergy. 🔹 UF for refractory cases, but monitor renal function closely. 🔹 Aggressive diuresis improves outcomes even with transient ↑ creatinine.

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Key Principles in Rx 1️⃣ Decongestion (diuretics/ultrafiltration). 2️⃣ Neurohormonal modulation (RAASI, SGLT2i). 3️⃣ Volume assessment (CVP, intrarenal Doppler). 4️⃣ Treat underlying systemic disease (e.g., sepsis). 5️⃣ Multidisciplinary care doi.org/10.3390/hear...

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🔑What is CRS? nature.com/articles/nrn... Types of CRS: 1️⃣ Type I: Acute HF → AKI 2️⃣ Type II: Chronic HF → CKD 3️⃣ Type III: AKI → Acute HF 4️⃣ Type IV: CKD → Chronic HF 5️⃣ Type V: Systemic diseases (e.g., sepsis) → Combined dysfunction

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🚨 Cardiorenal Syndrome (CRS): A Deadly Duo 🚨 Did you know the heart & kidneys are so intertwined that dysfunction in one can wreak havoc on the other? Let's dive into CRS today. A lucid read for every nephrology & cardiology fellow 🫀🩺 #MedTwitter #ISNTweetorial

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Great meeting with the @ISNEducation social media team; lots of exciting projects on the horizon! We're looking forward to what’s coming next, so stay tuned!

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