Our #microbiome is constantly talking to us. @ucsandiego.bsky.social researchers are learning their language #metabolism @ucsdpharmacy.bsky.social @pieterdorrestein.bsky.social
Cutting-Edge Technology Expands Dictionary of Human Metabolism
Researchers at UC San Diego are using state-of-the-art science to translate the hidden language of human metabolism.
buff.ly
I'm so glad to see this paper online! This was such an exciting project and I'm so grateful to all the co-authors in this work. A very special thanks to @pieterdorrestein.bsky.social for being such a great mentor and always available for the great discussions we had on this project!
Pieter Dorrestein@pieterdorrestein.bsky.social · last yr.If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...
Reverse metabolomics made these two papers a reality. www.nature.com/articles/s41... and www.cell.com/cell/fulltex... but hard for others to do similar analysis as the data science is at a high level. So @vincentlamoureux.bsky.social wanted to enable others with this powerful strategy rdcu.be/ebIF2
A guide to reverse metabolomics—a framework for big data discovery strategy
Nature Protocols - In this reverse metabolomics protocol, a tandem mass spectrometry spectrum is used as a search term to probe public metabolomic data. Analysis of the metadata connected with...
rdcu.be
It was a true privilege to have worked on this project! Thanks to @pieterdorrestein.bsky.social, Rob, Rodolfo, @helenamrusso.bsky.social, @simonezuffa.bsky.social, and other co-authors for all the fun we had along the way!
Pieter Dorrestein@pieterdorrestein.bsky.social · last yr.It’s not every day one gets to publish an article with NASA astronauts. This journey started in 2019 and withe the goal to understand the microbial and chemical make-up of the space station. We had lots of experience with analysis from swabs on earth.
Such a wonderful SIMB workshop on @gnps2.bsky.social covering classical mol networking, FBMN, ion identity based mol networking, FBMN-STATS, gnps-dashboard, CMMC-kb, Modifinder, MicrobeMASST, MassQL, and limited ReDU - many were covered at a workshop for the first time. 1/4
