#BLUEProtocol uses bedside #lung ultrasound at 6 points to rapidly evaluate acute respiratory failure and detect key causes of dyspnea. 📖 Read the full article to learn more:

Online #GLP1 receptor agonist prescribing often lacks direct clinician interaction, relying mainly on questionnaires and issuing prescriptions quickly—even for compounded, non-FDA-approved formulations. ja.ma/4w3xdfW

💡 JAMA Insights: #POCUS by trained clinicians is a guideline-endorsed alternative to chest radiography for #pneumonia diagnosis, offering higher sensitivity and specificity, immediate results, and no ionizing radiation. ja.ma/4h7y6QW

Blood-based biomarkers, anti-tau therapies, and prevention strategies in #AlzheimersDisease were among the key topics presented at #AAIC2026. 🎙️ Listen to JAMA Associate Editor Gil Rabinovici, MD, discuss conference highlights in the JAMA Medical News podcast: ja.ma/3Tqv54x

💬 Editor's Note: The US Food and Drug Administration and the Federal Trade Commission provide limited oversight for low-risk #DigitalHealth wellness devices, aiming to preserve innovation while requiring truthful, substantiated claims. ja.ma/454dSAs

💬 Perspective: Much of today’s #WearableData may function as results of unknown significance, appearing clinically useful without clear evidence, reference ranges, or defined roles in diagnosis and treatment. ja.ma/4hMPYRl

“Not just exercise more, eat less. That is not a full lifestyle medicine intervention.” Beth Frates, MD, shares her perspective while attending the #JAMASummit on #Obesity. Learn more: ja.ma/4hbyAp7

For large-core #AcuteIschemicStroke selected by noncontrast computed tomography, intra-arterial #Thrombectomy was associated with better 1-year functional outcomes and quality of life vs medical management alone. ja.ma/4w6PWav

In metastatic #ColorectalCancer, adding high-dose vitamin D3 to chemotherapy plus bevacizumab did not improve progression-free survival vs standard-dose vitamin D3. ja.ma/450DfD8

For large-core #AcuteIschemicStroke selected by noncontrast computed tomography, intra-arterial #Thrombectomy was associated with better 1-year functional outcomes and quality of life vs medical management alone. ja.ma/3Rvy76W

In metastatic #ColorectalCancer, adding high-dose vitamin D3 to chemotherapy plus bevacizumab did not improve progression-free survival vs standard-dose vitamin D3. ja.ma/3RGAkMT

💬 Editor's Note: The US Food and Drug Administration and the Federal Trade Commission provide limited oversight for low-risk #DigitalHealth wellness devices, aiming to preserve innovation while requiring truthful, substantiated claims. ja.ma/45CaOLW

💬 Perspective: Much of today’s #WearableData may function as results of unknown significance, appearing clinically useful without clear evidence, reference ranges, or defined roles in diagnosis and treatment. ja.ma/4pZ5sUE

💬 Viewpoint: Under the US Food and Drug Administration January 2026 guidance, many low-risk #DigitalHealth tools fall outside medical device oversight, but some may still influence health decisions without clear evidence standards. ja.ma/4cg8b66

In this podcast, JAMA Deputy Editors Linda Brubaker, MD, and Christopher Muth, MD, discussed the latest science: ➡️ Elevated LDL Cholesterol and Global Burden of Disease Analysis, ➡️ Intervention for Growth in Small-for-Gestational-Age Infants, and more. ja.ma/4fxPpcK

A text-delivered video #SafeSleep intervention for low-income families did not significantly improve reported usual supine sleep, room sharing without bed-sharing, soft bedding nonuse, or pacifier use. ja.ma/4fRTeII

📊 JAMA Clinical Guidelines Synopsis: The newly released Surviving #Sepsis Campaign guidelines endorse early broad-spectrum antibiotics, rapid fluid resuscitation, and deescalation strategies for adults with sepsis or septic shock. ja.ma/4xBQHtx

Atherosclerotic #cardiovascular disease (ASCVD) remains a leading cause of global #mortality and is strongly associated with cumulative exposure to atherogenic lipoproteins across the lifespan. 🎙️ Listen to the latest JAMA Clinical Reviews podcast: ja.ma/4bskR9N

💬 Editorial: Perioperative #dapagliflozin reduced postoperative #AcuteKidneyInjury after elective cardiac surgery, supporting further trials of sodium-glucose cotransporter 2 inhibitors for kidney protection. ja.ma/4yZ7kRi

Among patients undergoing elective cardiac surgery, perioperative #dapagliflozin reduced postoperative #AcuteKidneyInjury compared with placebo over 7 days. ja.ma/4w8UXPZ

📌 How can clinicians and researchers stay up to date on the most clinically relevant trials? Follow JAMA+ Trials to get curated access to the best of the JAMA Network’s trial research, commentaries, and educational resources: jamanetwork.com/channels/tri...

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JAMA Neurology EIC S. Andrew Josephson, MD, selected this as his 2025 Editor's Choice: Clinical Trial of the Year for its important findings on relapse risk after discontinuing disease-modifying therapy in stable MS. 🔗 Read the Editorial: ja.ma/3S5wbSN

In a RCT published in JAMA Neurology, stopping first-line disease-modifying therapy led to more inflammatory disease activity vs continuing treatment for patients with stable #MultipleSclerosis (MS) for at least 5 years. ja.ma/3TOFkzx

Ten years after the US Centers for Disease Control and Prevention first issued #opioid prescribing guidance, clinicians are still balancing caution about #addiction risk with the need to treat pain effectively. 🎙️ Listen: ja.ma/4g7pdpn

Lifestyle interventions, anti-tau therapy, and treatment for agitation in #Dementia were among the major topics discussed from #AAIC2026. 🎧 Listen to Gil Rabinovici, MD, discuss this and more with JAMA Medical News’ Rita Rubin: ja.ma/4cirdsC

For adults seeking #SmokingCessation, nicotine #ECigarettes should be discussed alongside US Food and Drug Administration-approved medications because they are more effective than nicotine replacement therapies and less harmful than cigarettes. ja.ma/4xe8FBT

💡 JAMA Insights: #SleepHealth and #obesity are linked, with insufficient sleep quantity and poor sleep quality associated with weight gain, less healthy diet, and incident obesity. ja.ma/453NmHf

Elevated #LDLCholesterol was associated with 3.6 million deaths worldwide in 2023, and the total burden has risen since 1990 as population growth and aging offset declines in age-standardized cardiovascular rates. ja.ma/3TowAAd

From 2011 to 2024, #Alcohol use, binge drinking, and heavy drinking increased among pregnant women in the US, indicating ongoing public health concerns about prenatal alcohol exposure. ja.ma/4wuHG5b

Among term infants born #SmallForGestationalAge, an integrated intervention improved weight and weight-for-age z score at 12 months vs usual care and was associated with less underweight, stunting, wasting, and anemia. ja.ma/4bncaxs