This case report describes a 60-year-old woman presenting with sudden loss of muscle tone with preserved consciousness and severe daytime sleepiness. ja.ma/4fMpmgB

In #PrimaryProgressiveAphasia, automated #SpeechAnalysis of a brief picture description task distinguished nonfluent, logopenic, and semantic variants and produced interpretable speech profiles. ja.ma/4w4A2xg

In #MultipleSclerosis, higher serum glial fibrillary acidic protein was associated with greater risk of progression independent of relapse activity, while neurofilament light chain was more closely associated with relapse risk. ja.ma/3TTRpU9

In a RCT published in JAMA Neurology, stopping first-line disease-modifying therapy led to more inflammatory disease activity vs continuing treatment for patients with stable #MultipleSclerosis (MS) for at least 5 years. ja.ma/3TOFkzx

Patients with functional #neurological disorder exhibit frequent psychiatric and neurological comorbidities, worse functional outcomes, higher health care use, and increased mortality compared with multiple sclerosis. ja.ma/3Rvrq4N

Interview with Kelly G. Gwathmey, MD, author of Efficacy and Safety of Gefurulimab in Generalized Myasthenia Gravis: The PREVAIL Phase 3 Randomized Clinical Trial. Hosted by Cynthia E. Armand, MD. ja.ma/4bi8T2s

Gefurulimab and Generalized Myasthenia Gravis

Interview with Kelly G. Gwathmey, MD, author of Efficacy and Safety of Gefurulimab in Generalized Myasthenia Gravis: The PREVAIL Phase 3 Randomized Clinical Trial. Hosted by Cynthia E. Armand, MD.

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💬 Editorial: Road traffic noise may be a novel place-based risk factor for #ParkinsonDisease, adding to evidence linking environmental toxicants and pollution exposures to disease risk. ja.ma/4fEM8XT

Environmental Risk in Parkinson Disease—Bring the Noise

Parkinson disease (PD) affects over 11 million people worldwide and is among the fastest-growing causes of neurological death and disability.1 This trend highlights the critical need to identify and address modifiable risk factors of PD. Several environmental chemicals have been linked to PD risk,...

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Among residents exposed to higher traffic noise, a quieter residential side was associated with lower #ParkinsonDisease risk, suggesting a possible role for noise mitigation in housing and urban design. ja.ma/4fEM1vr

Road Traffic Noise and Risk of Parkinson Disease

This cohort study evaluates the association between long-term exposure to road traffic noise and risk of Parkinson disease.

ja.ma

💬 Editorial: In anti–acetylcholine receptor antibody–positive generalized #MyastheniaGravis, gefurulimab improved activities of daily living and quantitative disease scores over 26 weeks. ja.ma/4h3b0em

First Effective Nanobody in Myasthenia Gravis Therapy

In generalized myasthenia gravis (gMG), a continuously increasing spectrum of immunomodulatory agents with different mechanisms of action have been studied, including T- and B-cell directed drugs and drugs acting on downstream antibody-metabolism, such as neonatal Fc receptor (FcRn) and complement...

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Gefurulimab, a complement component 5–blocking nanobody, provided early and sustained benefit in generalized #MyastheniaGravis and was well tolerated with once-weekly self-administered subcutaneous dosing. ja.ma/4h8taeJ

Gefurulimab and Generalized Myasthenia Gravis

This randomized clinical trial compares the novel dual-binding nanobody gefurulimab vs placebo for treating anti–acetylcholine receptor antibody–positive generalized myasthenia gravis.

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💬 Viewpoint: Medicolegal advocacy from neurologists can support patients with neurologic illness in securing rehabilitation, disability benefits, and housing stability, with implications for individual and population health. ja.ma/4bknYk6

Moving Beyond Legal Phobia to Medicolegal Advocacy in Neurology

This Viewpoint discusses neurologists writing letters on patients’ behalf for legal proceedings.

ja.ma

Limiting #ParkinsonDisease genetic testing to onset ≤50 years misses most carriers of pathogenic variants, including many eligible for gene-targeted therapies; broader, age-inclusive strategies may improve diagnostic yield. ja.ma/3RXVm9J

#Dementia prevalence increased over 2 decades in Mexico, Peru, and Puerto Rico, while rates remained stable in Cuba and the Dominican Republic, indicating an uneven and rising burden compared with high-income countries. ja.ma/4heaiuy

📑 JAMA Neurology #Review: Gene delivery platforms for #Glioblastoma include viral vectors, lipid nanoparticles, and nanocarriers, with oncolytic HSV gaining approval and new nonviral approaches entering early clinical trials in #NeuroOncology. ja.ma/4bomipD

Presented today at #AAIC26: #Dementia prevalence increased over 2 decades in Mexico, Peru, and Puerto Rico, while rates remained stable in Cuba and the Dominican Republic, indicating an uneven and rising burden compared with high-income countries. ja.ma/4fxCuaw

Presented at #AAIC26 from @JAMA.com: #Amyloid clearance was most efficient in gyral crests, not sulcal depths, and correlated locally with reduced #tau #pathology and #neurodegeneration after aducanumab therapy in #AlzheimerDisease. ja.ma/3SYsxtZ

This case report describes a 71-year-old woman presenting with altered speech, gait difficulties, and hearing loss diagnosed with infratentorial superficial siderosis and a thoracic spinal cord cleft. ja.ma/4vKlSlR

Among veterans with prior #TraumaticBrainInjury, the plasma p-tau217/Aβ42 blood test for #AlzheimerDisease missed over half of brain amyloid-positive cases, indicating reduced diagnostic accuracy in this population. ja.ma/4wmWkLp

A patient with isolated peripheral nerve vasculitis developed reversible bilateral hypoglossal palsy and tongue atrophy, with resolution of bulbar symptoms following immunosuppressive therapy and reinnervation, a rare neurological outcome. ja.ma/3SVI9yg

💬 Perspective from JAMA: Monoclonal antibodies for #AlzheimerDisease clear brain amyloid-β and modestly slow cognitive decline in early stages, supporting a causal role but with clinically limited impact and risk for imaging abnormalities. ja.ma/4acXv7D

Among patients with familial or sporadic #Frontotemporal #Dementia, cerebrospinal fluid TMEM106B levels were lower with greater disease severity, progression, smaller brain volumes, and in carriers of the protective rs1990622 genotype. ja.ma/3SzcpPm

Machine learning analysis of patient-clinician conversations identified cognitive impairment with sensitivity 68% and specificity 64%, supporting passive speech-based screening in routine #PrimaryCare. ja.ma/3Q7JeCl

Machine learning analysis of patient-clinician conversations identified cognitive impairment with sensitivity 68% and specificity 64%, supporting passive speech-based screening in routine #PrimaryCare. ja.ma/4a48KPx

💬 Editorial: Routine clinical conversations in #PrimaryCare contain acoustic signals that machine learning models can use for passive cognitive impairment screening, but risks and potential biases must be evaluated before clinical adoption. ja.ma/4ePVXTw

Among adult #Ebola survivors, neurological symptoms such as memory loss, headaches, and depression remained common even 7 years post-infection, although most improved over time. ja.ma/4oycleA

IL-6 receptor blockers provided favorable recovery and visual improvement after acute attacks in #MOGAD and #AQP4NMOSD, but controlled trials are needed to determine effects on long-term disability. ja.ma/4v7ZKkO

Machine learning analysis of patient-clinician conversations identified cognitive impairment with sensitivity 68% and specificity 64%, supporting passive speech-based screening in routine #PrimaryCare. ja.ma/4uCXwsI

Pressure-induced paroxysmal dystonia was diagnosed using clinical observation and video EEG, with symptoms abolished by low-dose clonazepam. Brief episodes and sensorimotor hypersensitivity distinguished it from other #MovementDisorders.

Pressure-Triggered Dystonia in a 35-Year-Old Woman

This case report describes a 35-year-old woman with history of paroxysmal dystonic episodes reproducibly triggered by pressure on the right upper limb.

jamanetwork.com

Machine learning analysis of patient-clinician conversations identified cognitive impairment with sensitivity 68% and specificity 64%, supporting passive speech-based screening in routine #PrimaryCare. ja.ma/43ziX2X

Among adult #Ebola survivors, neurological symptoms such as memory loss, headaches, and depression remained common even 7 years post-infection, although most improved over time. ja.ma/3S9IQ72