Humbled to contribute structurally to this incredible work on CRBN biology, led by Vanessa. Big kudos 👏 to the amazing teams at GSK and @thewoolab.bsky.social . Huge thanks to my mentor, Gabe Lander @landerlab.bsky.social , for helping me step into the field 😊🙌🥂🎉 My first ever @nature.com 🫶🌿

The Woo Lab@thewoolab.bsky.social · 7mo ago

Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...

Exciting new work from @thewoolab.bsky.social just out @nature.com www.nature.com/articles/s41...

Identification of an allosteric site on the E3 ligase adapter cereblon - Nature

An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

nature.com

Exited to share my first PostDoc contribution! Like Magellan explored the globe, you can explore your cryoEM data with Magellon. Congrats to all involved. Scott Stagg Lab & Michael Cianfrocco Lab @landerlab.bsky.social www.biorxiv.org/content/10.1... 🌎❄️🔬

🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

Surface morphometrics reveals local membrane thickness variation in organellar subcompartments https://www.biorxiv.org/content/10.1101/2025.04.30.651574v1

Absolutely loved working with you @landerlab.bsky.social, on this! 🙌 Leraned so much- not just about these fascinating machines from the ubiquitin cryoEM community but also the art of crafting figures that ‘tell’ the science. Honored to help weave together the community’s work with #COSB

Lander Lab@landerlab.bsky.social · last yr.

Our latest review is out in COSB! Led by Zeba Rizvi @zrizvi.bsky.social,‬ we explore how cryo-EM has brought new insights to Cullin RING ligases - from conformations to allosteric control, cryo-EM has massively improved our understanding of these dynamic molecular machines. tinyurl.com/y4sza8dh

First post here- Hello Bluesky! Quick science query: These 2D classes are from negative stain of a FLAG pulldown (HEK cell eluate). Does this look like a real complex or a common contaminant? Would live to hear from anyone who’s worked on similar prep! #negativestainEM #pulldown #HEKcells