New review out in @NatureRevMicro on the complex rltnshp btween metabolism & AMR! A true labor of love from previous postbac Mehrose, grad students Varun & Zirui, and collaborator @drrobsmith.bsky.social (plus figures I'll likely use for many talks to come 😊) rdcu.be/eaES2

The role of bacterial metabolism in antimicrobial resistance

Nature Reviews Microbiology - In this Review, Ahmad et al. examine how antibiotics influence bacterial metabolism and how metabolism, in turn, affects drug efficacy and the emergence and evolution...

rdcu.be

Harmful algal blooms are a threat to human health. Yet, we don't understand how changes in gene expression of the main culprit, Microcystis, facilitate blooms. Our latest collab, led by Dr. Lauren Krausfeldt and @jochrome1.bsky.social , sheds light on this process. journals.asm.org/doi/full/10....

Transcriptional profiles of Microcystis reveal gene expression shifts that promote bloom persistence in in situ mesocosms | Microbiology Spectrum

Harmful algal blooms represent a threat to human health and ecosystems. Understanding why blooms persist may help us develop warning indicators of bloom persistence and create novel mitigation strateg...

journals.asm.org

Happy to share our most recent manuscript with the Bsky community. Bacterial infections that reach a high density are challenging to treat with antibiotics, but we do not know why. We present evidence showing that nucleotide synthesis is intimately involved. journals.asm.org/doi/10.1128/...

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics | Microbiology Spectrum

If a bacterial population can grow and reach a sufficiently high density, routine doses of antibiotics can be ineffective. This phenomenon, called the inoculum effect, has been observed for nearly all...

journals.asm.org

Happy to see the community growing here. Our lab is interested in understanding how bacterial metabolism impacts antibiotic resistance. We often hop into other cool projects outside our primary interest, ranging from understanding algal blooms to identifying quantum events in biological systems.