Max Korbmacher
@maxkorbmacher.bsky.social
Imaging neuroscientist. Brain (bio)markers, big data, MRI, meta & open/better science. Views are my own.
Mapping hippocampal subfield heterogeneity across neurological disorders by normative modeling. doi.org/10.1038/s414...
Mapping hippocampal subfield heterogeneity across neurological disorders by normative modeling - Nature Communications
This study establishes age-specific reference ranges for hippocampal subfields and shows that personalized deviations from these norms can distinguish neurological disorders and help assess cognition ...
doi.org
Transferable conditional brain charts link cortico-subcortical structure to Alzheimer's disease progression doi.org/10.48550/arX...
Transferable conditional brain charts link cortico-subcortical structure to Alzheimer's disease progression
Normative models chart how brain measures vary across the lifespan, expressing each individual as a deviation from a healthy reference. However, most regional models of cortical thickness disregard de...
doi.org
Schwaba, T., Clapp Sullivan, M.L., Akingbuwa, W.A. et al. Robust inference and correlates from genetic associations with personality (2026). doi.org/10.1038/s415...
Robust inference and correlates from genetic associations with personality - Nature
The genetic architecture of personality is robustly generalizable, minimally confounded and widely relevant to human experience.
doi.org
Effect sizes for brain-based predictive models of cognition across the lifespan doi.org/10.1038/s442...
Effect sizes for brain-based predictive models of cognition across the lifespan - Communications Psychology
This review synthesizes literature on brain-based cognitive predictions using large-scale datasets, examining how methodological choices and data-related factors impact model performance. Key advances...
doi.org
Brain age estimations depend on methodological choices (surprise, surprise) - here, connectivity features were used. A Multiverse Approach to Brain Age Prediction: Exploring the Impact of Modality, Bias Adjustment, and Atlas doi.org/10.64898/202...
doi.org
Potential And Limitations Of ComBat For The Harmonization Of Multi-Site Neuroimaging Studies doi.org/10.31234/osf...
Potential and Limitations of ComBat for the Harmonization of Multi-Site Neuroimaging Studies
Integrating multiple neuroimaging datasets is a key strategy to obtain the increasing sample sizes needed to advance neuroscience. However, this requires addressing known biases due to differences in ...
doi.org
Normative modeling in neuroimaging across psychiatric and neurological disorders: a systematic review and the NORMA reporting checklist Naoki Takamatsu et al 2026 assets-eu.researchsquare.com/files/rs-103...
assets-eu.researchsquare.com
New in @natneuro.nature.com : Cortical thickness changes precede PET Abeta positivity with several years @lcbc-uio.bsky.social @jamesmroe.bsky.social www.nature.com/articles/s41...
Cortical thickness changes precede high levels of amyloid by at least 7 years - Nature Neuroscience
Longitudinal MRI reveals that the cortex becomes relatively thicker years before amyloid positivity is detected on PET, providing insight into the earliest brain changes and potential consequences of ...
nature.com
The Dead Salmons of AI Interpretability arxiv.org/abs/2512.18792 The famous #fMRI cautionary tale re-born as an analogy for the AI age! @practicalfmri.bsky.social
If a transgender patient visits a psychiatrist in a hospital, is it fair to say that they have «severe psychiatric morbidity»? We believe research should be more rigorous. With 49 co-authors, including: @maxkorbmacher.bsky.social @erininthemorning.com @natacha.bsky.social @frende.bsky.social
David R. Banos@davidrbanos.bsky.social · 6mo agoOur letter of concern about the Finnish study is now published in Acta Paediatrica. The Finnish study has received a total of 5 letters/commentaries, so far. Most of the overlapping concerns are statistical/methodological. onlinelibrary.wiley.com/doi/10.1111/...
Nice example of how research data can be validated against real world clinical data. doi.org/10.1016/j.co...
Redirecting
doi.org
We just launched #GuesstheReplication (GutheR). It is a challenging game where you predict replicability based on the abstract and title of an original study. Play it now and beat my high score at lukasroeseler.github.io/GuessTheRepl... or use our free slides for teaching zenodo.org/records/1985...
Cognitive function at age 13 predicts dementia 60 years later, even controlling for cardiovascular and cardiometabolic risk. @KWalhovd www.medrxiv.org/content/10.6...
medrxiv.org
Fun facts about biological differences in sleep duration. But the title is misleading. Not about ageing but cross-sectional correlation. doi.org/10.1038/s415...
Sleep chart of biological ageing clocks in middle and late life - Nature
A cross-organ, multi-omics U-shaped relationship between sleep duration and biological ageing clocks highlights the potential of sleep optimization to promote healthy ageing, lower disease risk and ex...
doi.org
Interested in neuroimaging and cognition in aging and want to work with us? We have an open position @KWalhovd @LCBC_UiO 2411.webcruiter.no/Main2/Recrui...
Researcher in neuroimaging and cognitive change of aging
We have a 3-year researcher position for analysing longitudinal brain MRI data in relation to cognitive- and other biomarker data.The shift to a biomarker-based definition of Alzheimer’s disease (AD) ...
2411.webcruiter.no
pubmed.ncbi.nlm.nih.gov/42083734/htt...
Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival - PubMed
Anatomical tumor distribution provided prognostic information beyond overall tumor burden in glioblastoma. Regional patterns expand on the anatomical basis of symptoms. The survival benefit associated...
pubmed.ncbi.nlm.nih.gov
Use of brain age models frequently lead to wrong conclusions - unfortunately it is not easy to fix. Fortunately, there are better alternatives. @edvardg.bsky.social @fmrib-steve.bsky.social @didacvp.bsky.social @maxwellelliott.bsky.social @k.b.walhovd www.medrxiv.org/content/10.6...
Reconsidering Brain Age: Why Age-Prediction Models Fail as Measures of Brain Aging
Brain age models - machine-learning predictions of chronological age from brain imaging - are widely interpreted as markers of accelerated brain aging. Here we show that this interpretation cannot be ...
medrxiv.org
🏓😊 Dürr, P., El Gheche, M., Maeda, G.J. et al. Outplaying elite table tennis players with an autonomous robot. Nature 652, 886–891 (2026). doi.org/10.1038/s415...
Outplaying elite table tennis players with an autonomous robot - Nature
An autonomous robot system, Ace, combines event-based vision and reinforcement learning to compete with elite human table tennis players, highlighting the potential of physical AI agents to perform co...
doi.org
What can we learn from 1,000 meta-analyses across 10 different disciplines? doi.org/10.1017/rsm....
What can we learn from 1,000 meta-analyses across 10 different disciplines? | Research Synthesis Methods | Cambridge Core
What can we learn from 1,000 meta-analyses across 10 different disciplines? - Volume 17 Issue 1
doi.org
Paradigm shifts are BS. "We find that three key measures of scientific progress—major discoveries, methods and fields—each demonstrate that science evolves cumulatively." doi.org/10.1098/rspa...
Debunking revolutionary paradigm shifts: evidence of cumulative scientific progress across science
Abstract. How can scientific progress be conceived best? Does science mainly undergo revolutionary paradigm shifts? Or is the evolution of science mainly c
doi.org
Nature recently published massive studies on the credibility of social science. We — the Norwegian co-authors on the robustness-paper, Gerit Pfuhl, @oysteinhernaes.bsky.social, @maxkorbmacher.bsky.social, and me — wrote an opinion piece about it (in Norwegian): www.forskersonen.no/forskning-kr...
Hva kjennetegner god vitenskap?
KRONIKK: Troverdig forskning er ikke forskning uten usikkerhet. Det er forskning som viser oss usikkerheten i stedet for å skjule den.
forskersonen.no
Brian Nosek@briannosek.bsky.social · 8mo agoSCORE, a collaboration of 865 researchers, is now released as three papers in Nature, six preprints, and a lot of data (cos.io/score/). SCORE examined repeatability of findings from the social-behavioral sciences and tested whether human and automated methods could predict replicability.
New paper alert 🤓🚨 Korbmacher, M., Boen, R., Andreassen, O.A. et al. White matter microstructure differences between 15q11.2 copy number variation carriers and non-carriers in mid-to-late life. Transl Psychiatry (2026). doi.org/10.1038/s413...
White matter microstructure differences between 15q11.2 copy number variation carriers and non-carriers in mid-to-late life - Translational Psychiatry
Translational Psychiatry - White matter microstructure differences between 15q11.2 copy number variation carriers and non-carriers in mid-to-late life
doi.org
Ren, J., Zhang, W., Dahmani, L. et al. Parkinson’s disease as a somato-cognitive action network disorder. Nature (2026). doi.org/10.1038/s415...
Parkinson’s disease as a somato-cognitive action network disorder - Nature
The substantia nigra and all Parkinson’s disease deep-brain stimulation targets are selectively connected to the somato-cognitive action network rather than to effector-specific motor regions.
doi.org
New paper in Imaging Neuroscience by James D. Kent, Alejandro de la Vega, et al: Neurosynth Compose: A web-based platform for flexible and reproducible neuroimaging meta-analysis doi.org/10.1162/IMAG...
Would be great to make migraine meds obsolete for rTMS responders. Q is whether the classification into responders can be done with cheaper means than fMRI... link.springer.com/article/10.1...
Prospective open-label trial of personalised connectivity-guided transcranial magnetic stimulation therapy for migraine - The Journal of Headache and Pain
The Journal of Headache and Pain - Migraine is a leading cause of disability worldwide, affecting hundreds of millions of individuals. Repetitive transcranial magnetic stimulation (rTMS) offers a...
link.springer.com
Multimodal meta-analysis of brain integrity in disorders of consciousness A Sala, M Meys, N Alnagger, N Beliy, S Abagnale… - 2026 scholar.google.com/scholar_url?...
scholar.google.com
New post! There was a lot of innovation in medicine and biomedical research this year, and I've tried to summarize the biggest ones in this blogpost. Medical breakthroughs in 2025. Plus a serious note at the end. www.scientificdiscovery.dev/p/medical-br...
Medical breakthroughs in 2025
... and a happy new year.
scientificdiscovery.dev
Sex‐Modified Effects of APOE‐ε4 on Spatial Patterns of Brain Atrophy: A Multi‐cohort Study Zhang et al doi.org/10.1002/alz7...
doi.org
Seems like gold for the Computational neuroscientists and data farmers among us: BrainScape: An open-source framework for integrating and preprocessing anatomical MRI datasets Muhammad Nabi Yasinzai, Remika Mito, Mangor Pedersen doi.org/10.1162/IMAG...
BrainScape: An open-source framework for integrating and preprocessing anatomical MRI datasets
Abstract. MRI has revolutionized our ability to investigate and understand brain structure and function in health and disease. A large amount of MRI data is widely available to researchers, both from ...
doi.org
Are tele-neuropsychology and in-person assessment scores meaningfully different? A systematic review and meta-analysis Jessica I. Alva et al doi.org/10.1080/1385...
Are tele-neuropsychology and in-person assessment scores meaningfully different? A systematic review and meta-analysis
Objectives: Despite growing evidence supporting tele-neuropsychology (teleNP), clinicians have voiced concerns about comparability to traditional in-person testing and the limited availability of t...
doi.org