Quick peek at the 2nd deck concrete pour of the VBRI expansion! From groundbreaking 11 months ago to this milestone! We're building the future of blood health research day by day. #PublicHealth #BloodHealth
Versiti Blood Research Institute
@versitiresearch.bsky.social
The VBRI is dedicated to hematology in all its facets, spanning basic, translational and clinical research, all with one goal: to make people’s lives better. https://versiti.org/versiti-blood-research-institute
The Kastrup Lab @ VBRI recently published a technique that may prevent dangerous blood clots after trauma without stopping normal healing. The targeted siRNA therapy keeps clotting proteins in the safe zone in the murine model. Learn more: journals.lww.com/jtrauma/abst...
We're proud to stand with our colleagues at @ash.hematology.org and the #Fight4Hematology campaign. Supporting emerging researchers and innovative care approaches strengthens our entire field's capacity to transform lives. Learn more and get involved: www.hematology.org/advocacy/fig...
Fight4Hematology - Hematology.org
Fight4Hematology
hematology.org
Congratulations to Bob Montgomery @versitiresearch.bsky.social for the being the recipient of the 2025 Harold R. Roberts Award @isth.org #ISTH2025
🥳The ISTH proudly presents the Harold R. Roberts Award to Dr. Robert R. Montgomery in recognition of his enduring contributions. His decades of leadership through the ISTH SSC and @versitiresearch.bsky.social reflect a career shaped by curiosity, perseverance & impact. Read more: bit.ly/3FO1cVe
PF4-dependent P-selectin expression assay in comparison to the heparin-induced platelet activation assay for the diagnosis of heparin-induced thrombocytopenia pubmed.ncbi.nlm.nih.gov/40191970/
PF4-dependent P-selectin expression assay in comparison to the heparin-induced platelet activation assay for the diagnosis of heparin-induced thrombocytopenia - PubMed
These findings suggest that the PEA is a promising functional test for HIT laboratory diagnostics based on the relatively high sensitivity; however, further studies are needed to validate its clinical...
pubmed.ncbi.nlm.nih.gov
Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression: pubmed.ncbi.nlm.nih.gov/40196236/
Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression - PubMed
The use of sNK cells in immunotherapy emerges as a potentially effective strategy to target and eliminate the majority of ovarian tumour clones, thereby providing a potential therapeutic opportunity i...
pubmed.ncbi.nlm.nih.gov
Great work and great collaboration! #TeamScience Learn more about Dr. Alan Mast and the Thrombosis and Hemostasis Lab at Versiti: versiti.org/versiti-bloo...
Versiti - Alan E. Mast, MD, PhD | Versiti Blood Research Institute
Dr. Mast is the Walter Schroeder Endowed Chair for Blood Research and a senior investigator at Versiti Blood Research Institute.
versiti.org
Emily R. Trunnell, Ph.D.@ertrunnell.bsky.social · last yr.A team at @coschoolofmines.bsky.social @versitiresearch.bsky.social Novo Nordisk, & UNC Chapel Hill developed a mathematical model to study how concizumab helps restore clotting function impaired in #hemophilia. www.jthjournal.org/article/S153...
Join us on Wed. 4/23 as we showcase the groundbreaking work of women in science at the VBRI! All ages are welcome as we profile the impactful innovation coming from @versiti.bsky.social and inspire future researchers. Register for free: versiti.org/ways-to-give... #WeResearchCures
At Versiti Perspective: Sickle Cell Disease, experts, advocates and community members joined to advance awareness and research. Guests heard from Chris Miskel, Prithu Sundd, Ph.D., and more, toured VBRI and learned their blood type. Give blood, save lives: bitly.versiti.org/3DaSHlw.
Check out publication by VBRI Senior investigator Bonnie Dittel and collaborators pubmed.ncbi.nlm.nih.gov/39643951/
Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels after B cell depletion with Ocrelizumab - PubMed
In multiple sclerosis (MS) the B cell depleting drug ocrelizumab has shown high efficacy in reducing inflammatory activity. Its mechanism of action is unclear due to B cell subset complexity and unkno...
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Senior Investigator and Program Co-Leader Alan Mast and collaborators pubmed.ncbi.nlm.nih.gov/39652409/
The roadmap to integrate diversity, equity, and inclusion in hematology clinical trials: an American Society of Hematology initiative - PubMed
Clinical trial design for classical hematologic diseases is difficult because samples sizes are often small and not representative of the disease population. The American Society of Hematology initiat...
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Senior Medical Director, Investigator Lisa Baumann Kreuziger and collaborators pubmed.ncbi.nlm.nih.gov/39930618/
Lack of Standardized Coding Limits Accuracy of Electronic Clinical Quality Measure for Pulmonary Embolism Diagnosis - PubMed
Guidelines for diagnosing pulmonary embolism (PE) start with a risk assessment using a pretest probability (PTP) tool, followed by D-dimer testing or computed tomography pulmonary angiography (CTPA) d...
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Associate investigator Dipa Pradhan-Sundd and collaborators pubmed.ncbi.nlm.nih.gov/39936985/
Heme-Oxygenase 1 Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice - PubMed
Pain constitutes a significant comorbidity associated with sickle cell disease (SCD). Analgesics serve as the primary method for pain management; however, the long-term effects of these drugs on the l...
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Associate investigator Yiliang Chen and collaborators pubmed.ncbi.nlm.nih.gov/39943809/
Angiotensin 1-7 and a TERT activator individually restore vasodilatory capacity within the microcirculation previous SARS-CoV-2 infection - PubMed
Angiotensin 1-7 and a TERT activator individually restore vasodilatory capacity within the microcirculation previous SARS-CoV-2 infection
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Associate investigator Joshua Muia and collaborators pubmed.ncbi.nlm.nih.gov/39945068/
Arginine Methylation by PRMT1 Affects ADAMTS13 Secretion and Enzymatic Activity - PubMed
These results demonstrate the crucial role of arginine methylation on ADAMTS13 secretion and activity. Our findings may shed new light on the mechanism of allosteric regulation of ADAMTS13, which may ...
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Senior Investigator Emeritus Thomas Abshire and collaborators pubmed.ncbi.nlm.nih.gov/39461724/
Duration of anticoagulation for venous thromboembolism in pediatric patients: Evaluation of the Duration of Therapy for Thrombosis in Children (Kids-DOTT) trial outcomes at 2 years - PubMed
These findings support durability of the Kids-DOTT randomized clinical trial findings of net clinical benefit at 2 years.
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Senior Investigator and Program Co-Leader Alan Mast and collaborators pubmed.ncbi.nlm.nih.gov/39536817/
Examining downstream effects of concizumab in hemophilia A with a mathematical modeling approach - PubMed
The effectiveness of concizumab is mediated through the blockade of TFPI anticoagulant activities in plasma and on multiple physiological surfaces. An important and previously unrecognized function of...
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Senior investigator Jieqing Zhu and collaborators in pubmed.ncbi.nlm.nih.gov/39906208/
Borrelia burgdorferi tolerates alteration to P66 porin function in a murine infectivity model - PubMed
<span><i>Borrelia burgdorferi</i> exists in a complex enzootic life cycle requiring differential gene regulation. P66, a porin and adhesin, is upregulated and essential during mammalian infection, but...
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Senior Medical Director, Investigator Lisa Baumann-Kreuziger and collaborators in pubmed.ncbi.nlm.nih.seniorgov/39911106/
Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation - PubMed
Not available.
pubmed.ncbi.nlm.nih.gov
Angela Beltrame spoke with students about her work, her journey and how she came to collaborate with the VBRI.
Dr. Alexis Smith spoke with students about her interest in science and her journey.
Communications Committee Presents: High School Students Bradley Tech high school students visit the VBRI on 1/29/2025 to learn more about science/research opportunities at the Versiti Blood Research Institute. Jayson Bartlein came to speak with the students about his role at the VBRI.
Communications Committee Presents: High School Students Bradley Tech high school students visit the VBRI on 1/29/2025 to learn more about science/research opportunities at the Versiti Blood Research Institute. We had Dawn Wenzel come share information regarding programs at MCW.
Check out publication by VBRI Senior investigator Bonnie Dittel and collaborators in pubmed.ncbi.nlm.nih.gov/39879070/
What's on the horizon? - PubMed
What's on the horizon?
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Senior Medical Director, Investigator Lisa Baumann Kreuziger and collaborators in pubmed.ncbi.nlm.nih.gov/39626301/
Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era - PubMed
Immune thrombotic thrombocytopenic purpura (iTTP) is a chronically relapsing disorder caused by autoantibody-mediated deficiency of ADAMTS13. Rituximab is frequently administered to prevent relapses, ...
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI EVP Medical Sciences Institute and Chief Medical Officer Matthew Anderson and collaborators in pubmed.ncbi.nlm.nih.gov/39642776/
High rates of MHC mismatches in HLA matched unrelated donor/recipient pairs and potential impact on hematopoietic cell transplant outcome - PubMed
NCML mismatching is present in HLA-matched unrelated HCT donor and recipient pairs and may contribute to outcomes in unrelated HLA-matched HCT.
pubmed.ncbi.nlm.nih.gov
Check out publication by VBRI Senior Investigator and Program Co-Leader Qizhen Shi and collaborators in pubmed.ncbi.nlm.nih.gov/39842018/
Platelet-Targeted Gene Therapy for Hemophilia A with Inhibitor History - PubMed
Platelet-Targeted Gene Therapy for Hemophilia A with Inhibitor History
pubmed.ncbi.nlm.nih.gov
Holiday Party 1.16.25 Look who came to party!!!!
