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Isabell Meier

@isabellmeier.bsky.social

Researcher with interest in chronic pain, fear/anxiety, opioids and the interplay of these. Member of the Leknes Affective Brain lab.

3 Posts182 Follower393 Folgt
Siri Leknes@sirileknes.bsky.social · 3w ago

Major paper out: A heroic* demonstration that even acute stress increases drug intake in healthy people *4-session 2x2 RCT with ~4 oxycodone injections in 66 volunteers - with repeated blinded 2-panel stress/control inductions (ReSST) 1/🧵 www.nature.com/articles/s44...

Effects of psychosocial stress on opioid self-administration in healthy participants: a randomized, placebo-controlled crossover trial - Nature Mental Health

In this triple-blind, randomized, placebo-controlled crossover trial, Eikemo et al. tested whether acute psychosocial stress increases opioid self-administration using controlled stress induction, oxy...

nature.com

Isabell Meier@isabellmeier.bsky.social · last yr.

Preprint alert! Data from our RCT comparing effects of preoperative Morphine, Oxycodone and Fentanyl makes us question - how beneficial are routine preoperative opioids? papers.ssrn.com/sol3/papers....

Intoxication and Other Subjective Effects of Preoperative Opioids: A Randomized Controlled Trial

Background: Opioids are often administered before anesthesia to reduce discomfort and stress or enhance well-being, but this practice rests on limited evidence.

papers.ssrn.com

Siri Leknes@sirileknes.bsky.social · last yr.

2/ In 199 surgery patients, opioids caused substantial intoxication, dizziness & sedation WITHOUT improving how 'good' they reported feeling Beneficial effects such as anxiolysis & relaxation were modest & observed in under half of patients Conclusion: We question routine presurgical opioid use

Graph showing ratings of feeling good, anxious, dizzy, relaxed, sad, intoxicated & other subjective effects of presurgical opioids