Drug development slows when early workflows don't support commercial realities. Promega's assay-ready Thaw-and-Use cells support commercial thinking early, moving faster from development to manufacturing without re-engineering. More at: https://ow.ly/8RN950Z4NBA #Bioassays #ThawAndUse

NanoBiT® PPI measures #protein-protein interactions in live cells in real time. GloMax® Galaxy imaging visualises where & how interactions unfold within cells. Example: CX3CR1 recruitment shifts from membrane to intracellular puncta during internalisation - https://ow.ly/8ks850ZuEWQ #NanoBiT

Does your compound engage its GPCR target in living cells? NanoBRET® Target Engagement measures this directly Fluorescent tracer competes with your compound for NanoLuc-tagged GPCR, giving true cellular IC₅₀. No radioactivity, no membrane prep More at: https://ow.ly/zOXF50Zl3hS #NanoBRET #GPCR

With rising biologic drug development, robust analytical methods are essential #PeptideMapping ensures therapeutic antibody quality Proteases with orthogonal cleavage improve sequence coverage, enhance characterisation, and reduce instrument time What challenges do you face? Let’s discuss!

Reminder: Free webinar tomorrow 4pm BST on Live Bioluminescence Imaging for real-time gene expression in human development. Learn how endogenously tagged bioluminescent reporters work in 2D and 3D stem cell models. Register at: https://ow.ly/zrH450ZjYrx #DevelopmentalBiology

New application note: CellTiter-Glo® 3D integrated with MO:BOT automation transforms 3D culture. Less variability, higher signals, better data from seeding to endpoint assay. Facing reproducibility challenges? This is worth reading. https://ow.ly/vHZj50Zl2z3 #3DCellCulture #LabAutomation

Exploring TDCC as a mechanism of action? Promega's complete workflow: Lumit® assays for cytokines, TDCC #Bioassays for T-cell-driven killing, HiBiT assays for target-cell death Clear data from screening to lot release for immune-oncology therapeutics More at: https://ow.ly/xyAC50Zga3m #TDCC

Exploring ADCP as a mechanism of action? Promega's complete workflow: Lumit® assays for FcγR engagement, ADCP Bioassays for phagocytosis readouts, HiBiT assays for target-cell loss. Clear data from screening to lot release. See our website for more information. #Biologics #ADCP

Free webinar Wed 29 July, 4pm BST: Live Bioluminescence Imaging for real-time gene expression in human development. Learn how endogenously tagged bioluminescent reporters work in 2D & 3D stem cell models. Register: https://ow.ly/Az2j50ZjY5k #DevelopmentalBiology

Daraxonrasib nearly doubles survival in metastatic pancreatic cancer versus chemo, targeting "undruggable" RAS for 40+ years. The mechanism was uncovered using NanoBRET® and NanoBiT® assays showing real-time complex formation in living cells. https://ow.ly/79cI50Zl2T5 #DrugDiscovery #NanoBRET

CellTiter-Glo® 3D Cell Viability Assay product page updated with comparison data, FAQs & protocol guidance. Delivers accurate viability in 30 minutes for spheroids, organoids & matrix-embedded cells across hanging-drop, ULA & Matrigel formats https://ow.ly/JA1F50Zk2Pv #3DCellCulture #CellViability

Promega has tools for Fc-mediated activity: Lumit® immunoassays for Fcγ engagement, ADCC Reporter Bioassays for functional responses, HiBiT assays for target cytolysis. Visit our website for more information. #Biologics #ADCC

Do you know how selective your kinase inhibitor is? New customers: 50% off your first compound with Promega's Kinase Selectivity Profiling Services (code #PROFILE26). Quantitative live-cell data across 192 or 300 full-length kinases. https://ow.ly/h4s350Z4F5P #KinaseProfiling #NanoBRET

Not all proliferation assays measure the same thing. Our guide compares five established approaches plus the new Lumit® Cell Proliferation Assay with a side-by-side comparison to help choose the right method. Read the guide at: https://ow.ly/xebg50Zk2rK #CellProliferation #Bioassays

Not all research questions suit off-the-shelf assays. Promega's custom assay development uses bioluminescent platforms (NanoBRET®, NanoBiT®, Lumit®) designed around your biology with expert support. Get better data faster. https://ow.ly/Koxk50Z2PC7 #CustomAssayDevelopment

How do you solve stutter at the source? This short video explains how Paradyme™ 27GY STR System uses Reduced-Stutter Polymerase technology to reduce back stutter during amplification. Covers mixture interpretation challenges and workflow benefits. Visit promega.com/clarity #ForensicScience

Promega UK has launched Lumit® Cell Proliferation Assay (Human Ki-67) – simple, wash-free, add-and-read. No fixation, dissociation, or wash steps. Faster results in 96- and 384-well formats, compatible with 3D cultures. More at: https://ow.ly/APSE50Zk20n #CellProliferation #Bioassays

Promega UK Launches Lumit Cell Proliferation Assay (Human Ki-67) for rapid, wash-free detection of a key proliferation marker

New homogeneous, plate-based assay enables researchers to track hKi-67 in a simple add-and-read format, delivering robust and reproducible results in less time

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Early screening decisions shape drug discovery Promega's screening and compound profiling services: flexible HTS up to 30K compounds/day, proven assays (NanoBRET®, Lumit®), deep profiling across kinase panels & key targets 2–3 week turnaround Learn more: https://ow.ly/xNHx50Z2Kvx #DrugDiscovery

Heart transplant patients require monthly invasive biopsies for rejection monitoring. Donor-derived cell-free DNA offers a non-invasive alternative with 97% negative predictive value. Royal Papworth's pilot uses Maxwell extraction. Read more: https://tinyurl.com/nbdvu9td #TransplantMedicine

Biochemical and cellular target engagement assays don't always match for kinases. NanoBRET® Target Engagement Kinase Assays measure compound binding to full-length kinases in live cells for physiologically relevant selectivity and potency data. https://ow.ly/nx2E50Z4EPm #KinaseBiology

Lumit® Human FcγR Binding Assays: homogeneous, no-wash method for antibody–receptor binding across six isoforms. 30–60 min workflow accelerates SAR studies and improves product quality. Replaces ELISAs/SPR. Learn more at: https://ow.ly/gslc50YYlJ8 #AntibodyDevelopment #FcReceptors

Paradyme™ 27GY STR System uses Reduced-Stutter Polymerase to minimise back stutter. Result: tangible improvements in detecting minor contributors in complex mixtures. 23 autosomal loci + Y-STR, all <400bp for degraded samples. Get in touch for full data. #ForensicScience #STRProfiling

Antibody power lies in Fc–FcγR engagement, triggering ADCC, ADCP and cytokine release Lumit™ Fc Receptor Binding Assays use split NanoLuc® complementation for clean, concentration-dependent signals in therapeutic antibody development Learn more at: https://ow.ly/7BQI50YYlkv #AntibodyDevelopment

Every compound screen asks: target-specific effect or cytotoxicity? New Nano-Glo® HiBiT Dual-Luciferase® Reporter System measures target protein and viability control in one well for a direct path to validated hits. More at: https://ow.ly/z2kL50Z4EGn #DrugDiscovery

Great to be a part of it!

London Infection Network for/by ECRs (LINE)@londoninfectionecr.bsky.social · last mo.

Today wouldn't happen without our sponsors: @microbiologysociety.org, Twist Bioscience, @stratechscientific.bsky.social, AltemisLab, IDT, Nikon, SARSTEDT, @nebiolabs.bsky.social,Thistle Scientific, @promegauk.bsky.social, Beckman Coulter, PCR Biosystems& @cambridgebio.bsky.social. #LINEsymposium2026

Weekend reading for CRO and pharma/biotech scientists 🔬 Promega UK's Paul Banks writes about real CRO partnerships, assay validation, lot traceability, PROTAC workflows and more. We cover the whole of the UK and Ireland. https://ow.ly/JQ0i50ZcNYR #CRO #DrugDiscovery #LifeSciences

Stutter peaks in STR profiling challenge forensic analysts. Paradyme™ 27GY STR System addresses stutter at the source using Reduced-Stutter Polymerase technology. Result: cleaner electropherograms and more confident results. More coming soon. #ForensicScience #STRProfiling

“Just pop it on and go.” Dr Mhairi Morris on how CellTiter-Glo® 3D avoids the matrix digestion step. Read more on the blog on our website or watch the full video on Promega UK's YouTube channel at: https://ow.ly/aCXY50YYcWK #LabEfficiency

Reminder: Free webinar tomorrow on Legionella testing automation. Learn how Maxwell® platforms improve lab efficiency for waterborne pathogen surveillance. Wednesday, 17 June 2026, 6.00pm BST. Register at: https://ow.ly/KJfX50YNoqk #LegionellaTesting #WaterQuality

25 years after the first PROTAC was described, vepdegestrant is now the first approved therapeutic in the class. Researchers using tools like HiBiT helped get us here. The field is just getting started. Read more: https://ow.ly/uH8t50Zaxmu #PROTAC #DrugDiscovery