#microsky #phagesky Jumbo #phage PhiKZ www.nature.com/articles/s41...

Excited to share the last installation of my PhD work. Worked with an all-star team on this one who really made this all come together beautifully. @ranidreamer.bsky.social @amardeeep.bsky.social @benadler.bsky.social and many others. www.cell.com/cell-reports...

Bacteriophages are normally classified as either virulent or temperate. Reality is, of course, more complicated! Here we show many bacterial isolates contain non-temperate phages that can persist through restreaking. Thanks to all co-authors for such a great collaboration!

@emggroupucph.bsky.social · 8mo ago

[1/3] Is your favorite bacterial isolate hiding a surprise lytic virus with a VERY different lifestyle? Finally I can proudly say that our paper on persistent phages is out in Nature Microbiology. rdcu.be/eWJEp. Well done @peterdoug.bsky.social

Join the Reck-Peterson lab in NYC as a HHMI Research Technician! This role will support our new work on the cell biology of secondary metabolite production in filamentous fungi. Apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Research Technician - Reck-Peterson Lab

Primary Work Address: 418 E 71st St #21, New York, NY, 10021 Current HHMI Employees, click here to apply via your Workday account. About the role: The Reck-Peterson lab studies the molecular mechanism...

hhmi.wd1.myworkdayjobs.com

@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs www.biorxiv.org/content/10.6...

Looking for a POSTDOC to work on jumbo phages (those with large genomes and fascinating cell biology), using our latest ASO technology (Gerovac M et al. 2025 Nature) to define RNA export mechanisms as well as to help to advance phage therapy. Here's the job ad.

Nucleus-Forming Phages: From Subcellular Organization and Viral–Host Interplay to Prospects for Phage Applications. Some new perspectives on chimalliviruses from our awesome longstanding Thai collaborators (and me). authors.elsevier.com/c/1mIJB4tPFp...

Powerful and important piece by an outstanding physician, scientist, and human being @kaminskimed.bsky.social pdf: jeremymberg.github.io/jeremyberg.g...

Marci Shore@marcishore.bsky.social · 10mo ago

My friend Naftali Kaminski is an Israeli physician, a professor at Yale, and the child of Holocaust survivors. For me he is a model of absorbing his parents' stories intensely, looking the horror of the 20th century in the eyes, and drawing the lesson of radical empathy for the suffering of others.

Super cool paper by @benadler.bsky.social @erinedoherty.bsky.social #phage #phagesky

Ben Adler@benadler.bsky.social · 10mo ago

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here: www.nature.com/articles/s41...

CURIOUS ABOUT PHAGE BIOLOGY!? CPIC lab at @helmholtzhzi.bsky.social is recruiting in the call +++ CURIOSITY IS INFECTIOUS +++ helmholtz-hzi.de/en/career/jo... Did you spot the phage? Please share!

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

Please share my 1 min video on the importance of maintaining NIH funding of infectious diseases and drug discovery research vs rising antibiotic resistance Drastic budget cuts harm our health and imperil the next generation of scientists More @UCSanDiego “Behind Every Breakthrough” bit.ly/3FlXQs3

Part of the recently completed PhD thesis of outstanding UC San Diego Medical Scientist Training Program student Alex Stream exploring Strep A molecular pathogenesis and vaccinology journals.asm.org/doi/10.1128/...

Seems like precisely the kind of person that HHS should want giving advice on structural/cell/molecular biology and more. That would require a leadership group that values disciplinary competency and independent expertise. villalab.ucsd.edu

Elizabeth Villa@thevillalab.bsky.social · last yr.

This is why I always have to filter my BLAST results. Nice analysis and interesting questions about the persistence of lytic phages in host populations. I suspect for chimalliviruses it's a product of longer latent periods and low infection efficiencies in many hosts.

Andrew Millard@milja001.bsky.social · last yr.

www.biorxiv.org/content/10.1... Searching for lytic phages in bacterial genome assemblies ..!

"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors” www.science.org/doi/10.1126/...

Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons

Klebsiella host strains infected with telomere phages can grow to be the dominant lineage in mixed populations.

science.org

Pleased to share our new paper out in 𝘑𝘰𝘶𝘳𝘯𝘢𝘭 𝘰𝘧 𝘊𝘭𝘪𝘯𝘪𝘤𝘢𝘭 𝘐𝘯𝘷𝘦𝘴𝘵𝘪𝘨𝘢𝘵𝘪𝘰𝘯 led by Monika Kumaraswamy, MD, now Chief of Infectious Diseases UTexas-Tyler Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? 🦠 🧫 🧵 1/6 www.jci.org/articles/vie...

We teamed up with our pals at @ucsandiego.bsky.social to show how jumbo #phages – huge viruses that prey on bacteria – use sneaky tricks to attack their victims! This knowledge could be used to leverage them as a tool to fight antibiotic resistance. Read more here: ow.ly/6VLa50Vucc5 🦠

Our work on cryptic infection of giant viruses was published today in @ScienceMagazine . We discovered a large virus hiding within a green algal genome producing virions. Collaborative effort spearheaded by Virginia Tech, University of Miami & NIOZ scientists. www.science.org/doi/10.1126/...

Cryptic infection of a giant virus in a unicellular green alga

Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. Here we describe a 617 kbp integrated giant viral element in the model green alga C...

science.org

Interrupting your regularly scheduled doom scrolling for some cool science by my awesome colleagues www.cell.com/cell-host-mi...

Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection

The pre-nuclear stage of Chimalliviridae infection and whether the phage nucleus is essential have remained mysterious. Armbruster and Rani et al. demonstrate that the phage nucleus is required for ph...

cell.com

Anyone who puts a reddit AMA on their CV should be immediately disqualified from holding a policy position.

Alt NIH Bluesky 🧪@altnih4science.bsky.social · last yr.

Thread on Jay Bhattacharya's weak scientific bona fides. Let's look at his CV. Too many scientists are saying "Bhattacharya has NIH funding, he can't be that bad." No. He wants revenge. He hasn't gotten an NIH grant since 2017, and the two grants then were only as a stats/econ consultant.

Flashy words like "revolutionize" are thrown around quite liberally in our field. In this case though, I can't think of a more appropriate word. This stuff is 🔥🔥🔥.

Ben Adler@benadler.bsky.social · last yr.

It is finally out! Muntathar Al-Shimary, @doudna-lab.bsky.social , @cresslab.bsky.social and I present a gene knockdown tool that works in diverse bacteriophages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check it out @naturemicrobiol.bsky.social www.nature.com/articles/s41...

𝐓𝐨𝐩 𝐂𝐚𝐮𝐬𝐞𝐬 𝐨𝐟 𝐃𝐞𝐚𝐭𝐡 𝐢𝐧 𝐔𝐒𝐀 𝟏𝟖𝟓𝟎𝐬 Tuberculosis Dysentery Cholera Malaria Typhoid Pneumonia/Flu Diphtheria Scarlet fever Meningitis Whooping cough 𝙎𝙖𝙣𝙞𝙩𝙖𝙩𝙞𝙤𝙣/𝙑𝙖𝙘𝙘𝙞𝙣𝙚𝙨/𝘼𝙣𝙩𝙞𝙗𝙞𝙤𝙩𝙞𝙘𝙨 𝐓𝐎𝐃𝐀𝐘 Heart disease Cancer Accidents COPD Stroke Alzheimer’s Diabetes Pneumonia/Flu Kidney disease Suicide

When I started my PhD, we knew exactly zero about the phage nucleus protein import pathway. Out today in Nature, parallel work by Claire Kokontis picking apart this pathway. PicA vs. Imp1, let the games begin. www.nature.com/articles/s41...

Multi-interface licensing of protein import into a phage nucleus - Nature

This study uncovers a highly conserved jumbo phage protein, Imp1, that possesses multiple interfaces to license protein import into a proteinaceous nucleus-like compartment, using a genetic selection ...

nature.com

Amazing story of a young cancer patient's resilience, a scary infection with MDR 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 expressing NDM-1, and successful application of phage therapy Care coordinated by Peds ID specialist and UCI Asst Prof Chulie Ulloa, MD—friend and former PSDP, K08, and UCPPFP mentee in the lab

Compassionate-use therapies for a deadly infection save the life of cancer patient - CHOC Pediatrica

CHOC infectious disease expert Dr. Erlinda “Chulie” Ulloa makes history nationally with investigational medication.

care.choc.org

Me: If this experiment works the first time, I'm throwing a party. Experiment: Did somebody say party?

I prefer shameful self-promotion by re-posting, but Pew and UCSD Biosciences have not migrated to this new utopia, so... Exciting news! I get to play with one of my besties @thevillalab.bsky.social today.ucsd.edu/story/kimber...

Kimberly Cooper and Elizabeth Villa Named Pew Innovation Fund Investigators

UC San Diego School of Biological Sciences Professors Kimberly Cooper and Elizabeth Villa have been selected by the Pew Charitable Trusts as members of its 2024 class of Innovation Fund Investigators.

today.ucsd.edu

Excited to share our new study with the Müller and @SchullerJm labs, online @nature: https://www.nature.com/articles/s41586-022-04971-z This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...

Structural diversity and oligomerization of bacterial ubiquitin-like proteins https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1

Structural diversity and oligomerization of bacterial ubiquitin-like proteins https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1

Bacteria possess a variety of operons with homology to eukaryotic ubiquitination pathways that encod

biorxiv.org