My team and myself are at the #eccb2026! Presenting analysis and predictive modelling of multi-omics and single-cell data related to cell signaling and equitable research at posters A-G.53, A-S.B.52, B-T.11, A-T.34, A-T.47, B-S.B.20, and C-P.18!
Nik Fortelny
@nikfortelny.bsky.social
Group Leader Computational Biology University of Salzburg
Looking for a postdoc in CompBio to lead our brand new EpiFlaMe consortium (Memory in Epithelial Cells - Organ Specificity and Cancer) This will be a major milestone in understanding memory processes in understudied cells with immune functions using integrative bioinformatics! plus.ac.at/fortelny
AG Fortelny - Universität Salzburg
Computational Systems Biology The group's research aims to understand the function and dysfunctions of biological systems on a molecular level, focusing on the complex regulation in large networks. We...
plus.ac.at
Open positions for 11 scientists! Our newly funded consortium "EpiFlaMe" is looking for 7 PhD students, 2 bioinformaticians (postdoc and technician), and 2 wet lab technicians. Interested? Submit your application until Feb 13, 2026 via www.plus.ac.at/epiflame
Applications are open for to our Doctoral Network on spatial biology and immuno-oncology! Our project is #14. Deadline: November 8th, 2025
Join spaXio, an EU-funded MSCA Doctoral Network exploring how cancer spreads & interacts with its surroundings using spatial multi-omics, 3D tumoroids, advanced imaging & AI. 🎓 14 fully funded PhD positions across Europe! 🌐 www.spaXio.eu 📝 Apply: civis.smapply.io/prog/spaxio_...
Postdoc position open! Digital Pathology: Therapy-response prediction using spatial biology University of Salzburg Deadline: October 26th, 2025 We look forward to hearing from you! www.plus.ac.at/biowissensch...
What are the differences between cells ex vivo and in vivo and how does this affect responses to experimental perturbations? Aarathy from our group compared the transcriptome of hematopoietic cells cultured ex vivo to those grown in vivo using two KO datasets (Perturb-seq and genetic KOs).
Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...
Bonsai: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data
Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...
biorxiv.org
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
Thank you #MUV for awarding @nikfortelny.bsky.social and me with the Researcher of the Month award for our recent publication in @natureportfolio.nature.com Nature Immunology. Very proud and we will continue with excellent science tailored to identifying novel therapies for precision medicine.
We are hiring two tenured full-time professors in Salzburg, Austria!
Ok, I tried to create my own list of people working on developing statistical or machine learning models applied to omics data. I am sure I missed a lot of cool people. If you'd like to be added, let me know. #Stats #ML #Omics go.bsky.app/73rcuJn
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
Thanks Nature Immunology for highlighting our paper with a Research Briefing, explaining the broader relevance with a bit of backstory and quotes from a reviewer and the editor. The paper is open access, but the Research Briefing is not – please use the following link for free access: rdcu.be/dGnH0
Baseline JAK–STAT signaling maintains immune cell homeostasis
Nature Immunology - Homeostatic immune cells remain perpetually vigilant against pathogens. We found that baseline JAK–STAT signaling supports the characteristic transcriptional and...
rdcu.be
Started during my postdoc but has now come to fruition! Systematic analyses of JAK-STAT signaling show the intriguing roles of this classical immune-response pathway in homeostasis. A big thanks to a whole consortium of experimental collaborators for a massive dataset!
🧬 WHAT KEEPS IMMUNE CELLS AWAKE & ATTENTIVE? It’s their neighbors – stimulation from the tissue environment. We profiled epigenomes & transcriptomes of 12 JAK-STAT mutant mice and found surprisingly strong effects at homeostasis. Paper just out in Nature Immunology: www.nature.com/articles/s41...