🦠 Fièvre de la Vallée du Rift, virus de Crimée-Congo, hantavirus… Face à ces fièvres hémorragiques virales, des chercheurs de l'Unité des Virus Emergents (UVE) ont misé sur une stratégie de réponse directe à l'épidémie : le repositionnement de médicaments. Plus d'infos: lemag.ird.fr/fr/combattre...

How Can Pharmacology Help Us Overcome the Challenges of Drug Repositioning as Antivirals to Treat Emerging Pathogens? The Example of Covid‐19 Revue entre Paris, Dijon, Marseille avec @franckdrtourte.bsky.social et le juteux @nathanpsmad.bsky.social ascpt.onlinelibrary.wiley.com/doi/10.1111/...

How Can Pharmacology Help Us Overcome the Challenges of Drug Repositioning as Antivirals to Treat Emerging Pathogens? The Example of Covid‐19

Pharmacological pitfalls and challenges in drug repurposing for emerging pathogens: lessons from COVID-19.

ascpt.onlinelibrary.wiley.com

Exciting news! Our latest study on SARS-CoV-2 variants and therapeutic strategies is now out in Scientific Reports Huge thanks to the Emergen_Biovar team for their contributions to this work @franckdrtourte.bsky.social @pf-ccb.bsky.social Full paper here: www.nature.com/articles/s41... #virology

Virological characterization of SARS-CoV-2 BA.2.86 variants by assessing antiviral susceptibility, in vivo infectivity and replicative fitness - Scientific Reports

In late 2023, the BA.2.86 and EG.5.1 SARS-CoV-2 variants co-circulated globally, raising concerns about enhanced immune evasion and altered replicative capacity. In this study, we assessed their virol...

nature.com

Just published in Antiviral research! 3D Liver Spheroids in the Fight Against Haemorrhagic Fever Viruses t.co/FuxQ76acrg @ird-fr.bsky.social @univ-amu.fr @insermpacacorse.bsky.social

🔬 New Research Breakthrough: Broad-Spectrum Inhibitors for Enteroviruses🦠Enteroviruses (EV) are a diverse group of viruses that can cause a range of illnesses, from mild fever to severe neurological complications.

🚨 New Insights on Hemorrhagic Fever Viruses & 3D Cell Culture Models 🦠 In the ongoing battle against hemorrhagic fever viruses (HFVs), the development of effective antiviral strategies remains a critical challenge.

www.nature.com/articles/s41... The main paper of my PhD thesis Due to the words limitation i will make it short but thanks to @franckdrtourte.bsky.social , Dr. Suzanne Kaptein, @neytsjohan.bsky.social, Christian Alfano, Carla Gomes da Silva, Ivan Gladwyn-ng, Emily Slowikowski and Prof Marques

Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity - Nature Communications

During the 2015–2016 outbreak, Zika virus infection was linked to birth defects. Here, the authors show that epidemic strains cause less severe disease in mouse embryos than pre-epidemic strains and c...

nature.com

Very happy to share about our paper on the sensitivity to mosnodenvir of the epidemic DENV2 lineage from the French Caribbean Islands in Nature communications doi.org/10.1038/s414... a thread 👇

Genomic surveillance reveals a dengue 2 virus epidemic lineage with a marked decrease in sensitivity to Mosnodenvir - Nature Communications

Dengue is a major public health threat in the Americas including the French Caribbean Islands, in which an epidemic has been ongoing since August 2023. Here, the authors investigate the genetic compos...

doi.org

larevuedesmedias.ina.fr/tpmp-cyril-h...

« TPMP » sur C8, le télépopulisme de Cyril Hanouna décrypté

BONNES FEUILLES. Dans son dernier livre, l’historienne des médias Claire Sécail analyse la façon dont « TPMP », l’émission de Cyril Hanouna sur C8, concourt « à la mise en tension de la société » et m...

larevuedesmedias.ina.fr

I'm really pleased and proud to share the peer-reviewed version of my first article as a p.i, and for a study we launched two years ago (a lifetime in SARS-CoV-2 timeline).

Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains

Since the start of the SARS-CoV-2 pandemic, the search for antiviral therapies has been at the forefront of medical research. To date, the 3CLpro inhi…

sciencedirect.com

Fresh from the oven our study on the functional diversity of cross-reacting antibodies generated during SARS-CoV-2 infection and illustrate how the balance between neutralizing and enhancing Abs facilitate variant emergence. doi.org/10.1080/2222...

New laboratory preprint Translational study in which we investigated the resistance barrier of two protease inhibitors (nirmatrelvir and ensitrelvir). www.biorxiv.org/content/10.1...