Tulsi Upadhyay
@tulsiupadhyay.bsky.social
Postdoctoral fellow at Bogyo Lab, Stanford University| Protein Biochemist| Proud IISER Bhopal Alumni
Excited to share my First GRS and GRC moments. It was very special #Bioorganic GRC2025. Met my PhD advisor @saraogi-ishu.bsky.social. Great Science and networking. Won “Outstanding Poster” award. Thanks to my postdoc advisor @mbogyo.bsky.social for the opportunity to present in GRC with him.
I'm thrilled to share that my second paper from my postdoctoral work is now published! A heartfelt thank you to my PI, Prof. Bogyo @mbogyo.bsky.social, for his unwavering support throughout this project. I am also deeply grateful to our fantastic collaboration team for making it a great success.🙌
Matt Bogyo@mbogyo.bsky.social · last yr.Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio link.springer.com/article/10.1...
🧪 Working to develop #drugs to treat #chikungunya ? Check out new fluorogenic substrates that help read out viral protease activity, developed by @tulsiupadhyay.bsky.social @westberglab.com @eunayoo.bsky.social @michaelzlin.bsky.social et al! pubmed.ncbi.nlm.nih.gov/39981948/
Amazing work by @sijiewang.bsky.social and our collaborators is out in JACS today. Interested in covalent inhibitors of protein-protein interactions? Check it out. pubs.acs.org/doi/10.1021/...
Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display
Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential to make highly selective binding interactions with targets. R...
pubs.acs.org
New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...
Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus
In search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. ...
pubs.acs.org
Another big publication from @sijiewang.bsky.social this week. Check out our efforts to use mRNA display to screen for covalent binding inhibitors of Staphylococcus aureus serine hydrolases. pubs.acs.org/articlesonre...
pubs.acs.org
Cool new preprint from @stanford-chemh.bsky.social fellow @mbogyo.bsky.social @stanfordmedicine.bsky.social www.researchsquare.com/article/rs-5...
Covalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formation
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. This is largely because infection sites are often difficult to localize and the bacteria forms biofilms which are n...
researchsquare.com
Excited to repost the news on this new platform!! Great collaborative work under the mentorship of @mbogyo.bsky.social is out for your read.
Matt Bogyo@mbogyo.bsky.social · 2y agoFirst real post on @bsky.app! Check out our latest work identifying covalent fragments as inhibitors of the Fph serine hydrolases in S. aureus. Great work from Tulsi Upadhyay and our many collaborators. www.researchsquare.com/article/rs-5...